Recent progress in 3D printing degradable polylactic acid-based bone repair scaffold for the application of cancellous bone defect
Xulin Hu,
Zhidong Lin,
Jian He,
Minchang Zhou,
Shuhao Yang,
Yao Wang,
Kainan Li,
Corresponding Author
Xulin Hu
Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China
Correspondence Xulin Hu and Kainan Li, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu 610081, China.
Email: [email protected] and [email protected]
Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal), Supervision (equal), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorZhidong Lin
The Second Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
Contribution: Data curation (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorJian He
College of Medical, Henan University of Science and Technology, Luoyang, China
Contribution: Data curation (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorMinchang Zhou
Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China
Contribution: Data curation (equal), Visualization (equal)
Search for more papers by this authorShuhao Yang
Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China
Contribution: Data curation (equal), Visualization (equal)
Search for more papers by this authorYao Wang
Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China
Contribution: Writing - original draft (equal)
Search for more papers by this authorCorresponding Author
Kainan Li
Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China
Correspondence Xulin Hu and Kainan Li, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu 610081, China.
Email: [email protected] and [email protected]
Contribution: Conceptualization (equal), Funding acquisition (equal), Resources (equal)
Search for more papers by this authorXulin Hu,
Zhidong Lin,
Jian He,
Minchang Zhou,
Shuhao Yang,
Yao Wang,
Kainan Li,
Corresponding Author
Xulin Hu
Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China
Correspondence Xulin Hu and Kainan Li, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu 610081, China.
Email: [email protected] and [email protected]
Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal), Supervision (equal), Visualization (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorZhidong Lin
The Second Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
Contribution: Data curation (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorJian He
College of Medical, Henan University of Science and Technology, Luoyang, China
Contribution: Data curation (equal), Writing - original draft (equal), Writing - review & editing (equal)
Search for more papers by this authorMinchang Zhou
Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China
Contribution: Data curation (equal), Visualization (equal)
Search for more papers by this authorShuhao Yang
Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China
Contribution: Data curation (equal), Visualization (equal)
Search for more papers by this authorYao Wang
Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China
Contribution: Writing - original draft (equal)
Search for more papers by this authorCorresponding Author
Kainan Li
Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu, China
Correspondence Xulin Hu and Kainan Li, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu 610081, China.
Email: [email protected] and [email protected]
Contribution: Conceptualization (equal), Funding acquisition (equal), Resources (equal)
Search for more papers by this authorXulin Hu, Zhidong Lin, and Jian He contributed equally to this study.
Abstract
Large size bone defects have become a growing clinical challenge. Cancellous bone, which has the highest volume ratio, the fastest replacement rate, and interconnected porous structure, plays a major role in bone repairing. Considering the structure and composition of cancellous bone, building a bionic 3D scaffold via customized-3D printing technology is the key to solving the problem. As the earliest degradable medical polymer material approved by Food and Drug Administration, polylactic acid has been proved to have excellent biosafety and can be copolymerized or blended with other synthetic polymers, natural polymers, and inorganic materials to improve its performance to better meet clinical applications. A series of biodegradable bone repair scaffolds based on polylactic acid composites and 3D printing technology are developed to achieve large bone defects. Here, we review the composition and structure of cancellous bone, highlighting the relationship to the requirements of bone repair scaffolds. The different types of polylactic-acid-based materials applied in 3D printing technology are described, emphasizing the connection between materials, preparation methods, and applications.
CONFLICT OF INTEREST
The authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
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