Volume 11, Issue 8 e201700363

FULL ARTICLE

Sensitive Leptospira DNA detection using tapered optical fiber sensor

Nurul H. Zainuddin

Department of Computer and Communication Systems, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

Wireless and Photonic Networks Research Centre (WiPNET), Universiti Putra Malaysia, Serdang, Selangor, Malaysia

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Hui Y. Chee,

Hui Y. Chee

Department of Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

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Muhammad Z. Ahmad,

Muhammad Z. Ahmad

Biotechnology and Nanotechnology Research Center, Malaysian Agricultural Research and Development Institute (MARDI), Serdang, Selangor, Malaysia

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Mohd A. Mahdi,

Mohd A. Mahdi

orcid.org/0000-0002-2843-181X

Department of Computer and Communication Systems, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

Wireless and Photonic Networks Research Centre (WiPNET), Universiti Putra Malaysia, Serdang, Selangor, Malaysia

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Muhammad H. Abu Bakar,

Muhammad H. Abu Bakar

orcid.org/0000-0003-2113-4553

Department of Computer and Communication Systems, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

Wireless and Photonic Networks Research Centre (WiPNET), Universiti Putra Malaysia, Serdang, Selangor, Malaysia

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Mohd H. Yaacob,

Corresponding Author

Mohd H. Yaacob

[email protected]

Department of Computer and Communication Systems, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

Wireless and Photonic Networks Research Centre (WiPNET), Universiti Putra Malaysia, Serdang, Selangor, Malaysia

Correspondence

Mohd H. Yaacob, Department of Computer and Communication Systems, Faculty of Engineering, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

Email: [email protected]

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Nurul H. Zainuddin,

Nurul H. Zainuddin

Department of Computer and Communication Systems, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

Wireless and Photonic Networks Research Centre (WiPNET), Universiti Putra Malaysia, Serdang, Selangor, Malaysia

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Hui Y. Chee,

Hui Y. Chee

Department of Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

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Muhammad Z. Ahmad,

Muhammad Z. Ahmad

Biotechnology and Nanotechnology Research Center, Malaysian Agricultural Research and Development Institute (MARDI), Serdang, Selangor, Malaysia

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Mohd A. Mahdi,

Mohd A. Mahdi

orcid.org/0000-0002-2843-181X

Department of Computer and Communication Systems, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

Wireless and Photonic Networks Research Centre (WiPNET), Universiti Putra Malaysia, Serdang, Selangor, Malaysia

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Muhammad H. Abu Bakar,

Muhammad H. Abu Bakar

orcid.org/0000-0003-2113-4553

Department of Computer and Communication Systems, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

Wireless and Photonic Networks Research Centre (WiPNET), Universiti Putra Malaysia, Serdang, Selangor, Malaysia

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Mohd H. Yaacob,

Corresponding Author

Mohd H. Yaacob

[email protected]

Department of Computer and Communication Systems, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor, Malaysia

Wireless and Photonic Networks Research Centre (WiPNET), Universiti Putra Malaysia, Serdang, Selangor, Malaysia

Correspondence

Mohd H. Yaacob, Department of Computer and Communication Systems, Faculty of Engineering, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

Email: [email protected]

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First published: 23 March 2018

https://doi.org/10.1002/jbio.201700363

Citations: 28

Funding information Ministry of Higher Education, Malaysia, Grant/Award Numbers: FRGS/1/2016/TK04/UPM/02/4, LRGS/UPM/700-2/1/LRGS/5526400

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Abstract

This paper presents the development of tapered optical fiber sensor to detect a specific Leptospira bacteria DNA. The bacteria causes Leptospirosis, a deadly disease but with common early flu-like symptoms. Optical single mode fiber (SMF) of 125 μm diameter is tapered to produce 12 μm waist diameter and 15 cm length. The novel DNA-based optical fiber sensor is functionalized by incubating the tapered region with sodium hydroxide (NaOH), (3-Aminopropyl) triethoxysilane and glutaraldehyde. Probe DNA is immobilized onto the tapered region and subsequently hybridized by its complementary DNA (cDNA). The transmission spectra of the DNA-based optical fiber sensor are measured in the 1500 to 1600 nm wavelength range. It is discovered that the shift of the wavelength in the SMF sensor is linearly proportional with the increase in the cDNA concentrations from 0.1 to 1.0 nM. The sensitivity of the sensor toward DNA is measured to be 1.2862 nm/nM and able to detect as low as 0.1 fM. The sensor indicates high specificity when only minimal shift is detected for non-cDNA testing. The developed sensor is able to distinguish between actual DNA of Leptospira serovars (Canicola and Copenhageni) against Clostridium difficile (control sample) at very low (femtomolar) target concentrations.

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REFERENCES

1A. I. Ko, C. Goarant, M. Picardeau, Nat. Rev. Microbiol. 2009, 7(10), 736.
10.1038/nrmicro2208
CAS PubMed Web of Science® Google Scholar
2D. A. Haake, P. N. Levett, in Leptospira and Leptospirosis, Vol. 387 (Ed: B. Adler), Springer, Berlin 2015.
10.1007/978-3-662-45059-8_5
Google Scholar
3B. Abela-Ridder, R. Sikkema, R. A. Hartskeerl, Int. J. Antimicrob. Agents 2010, 36, S5.
10.1016/j.ijantimicag.2010.06.012
CAS PubMed Web of Science® Google Scholar
4B. Adler, A. de la Peña Moctezuma, Vet. Microbiol. 2010, 140(3–4), 287.
10.1016/j.vetmic.2009.03.012
CAS PubMed Web of Science® Google Scholar
5S. Thayaparan, I. D. Robertson, A. Fairuz, L. Suut, M. T. Abdullah, Malays. J. Pathol. 2013, 35(2), 123.
CAS PubMed Web of Science® Google Scholar
6C. H. Chang, M. Riazi, M. H. Yunus, S. Osman, R. Noordin, Diagn. Microbiol. Infect. Dis. 2014, 80(4), 278.
10.1016/j.diagmicrobio.2014.08.012
PubMed Web of Science® Google Scholar
7I. Shah, Pediatr. Infect. Dis. 2012, 4(1), 4.
Google Scholar
8S. V. Budihal, K. Perwez, J. Clin, Diagn. Res. 2014, 8(1), 199.
PubMed Google Scholar
9M. Picardeau, E. Bertherat, M. Jancloes, A. N. Skouloudis, K. Durski, R. A. Hartskeerl, Diagn. Microbiol. Infect. Dis. 2014, 78, 1.
10.1016/j.diagmicrobio.2013.09.012
PubMed Web of Science® Google Scholar
10F. R. R. Teles, L. P. Fonseca, Talanta 2008, 77, 606.
10.1016/j.talanta.2008.07.024
CAS Web of Science® Google Scholar
11M. Barozzi, A. Manicardi, A. Vannucci, A. Candiani, M. Sozzi, M. Konstantaki, S. Pissadakis, R. Corradini, S. Selleri, A. Cucinotta, J. Lightwave Technol. 2017, 35(16), 3461.
10.1109/JLT.2016.2607024
CAS Web of Science® Google Scholar
12Y. Yan, S. Ding, D. Zhao, R. Yuan, Y. Zhang, W. Cheng, Sci. Rep. 2016, 6, 1.
10.1038/s41598-016-0001-8
CAS PubMed Web of Science® Google Scholar
13J. T. Gerig, Introductory Organic Chemistry, Elsevier: Amsterdam, 2012.
Google Scholar
14K. l. Skold, M. Svensson, G. Palmers, P. E. Andrén, United States Patent, US8663959B2, 2014.
Google Scholar
15C. Cenciarini-borde, S. Courtois, B. La Scola, Future Microbiol. 2009, 4(1), 45.
10.2217/17460913.4.1.45
CAS PubMed Web of Science® Google Scholar
16Z. Lewandowski, H. Beyenal, Fundamentals of Biofilm Research, CRC Press, Boca Raton, FL 2014.
Google Scholar
17G. Wandemur, D. Rodrigues, R. Allil, V. Queiroz, R. Peixoto, M. Werneck, M. Miguel, Biosens. Bioelectron. 2014, 54, 661.
10.1016/j.bios.2013.11.030
PubMed Web of Science® Google Scholar
18Z. Jennifer Guo, C. Boyter, G. Cohoon, E. Salik, W. Lin, GSTF J. Bioinform. Biotechnol. 2011, 1(1), 36.
Google Scholar
19L. Chen, C. Liu, M. D. Hughes, D. A. Nagel, A. V. Hine, L. Zhang, J. Biosens. Bioelectron. 2015, 6(2), 1.
PubMed Google Scholar
20Z. B. Bahşi, A. Büyükaksoy, S. M. Ölmezcan, F. Şimşek, M. H. Aslan, A. Y. Oral, Sensors 2009, 9(6), 4890.
10.3390/s90604890
CAS Web of Science® Google Scholar
21T. A. Birks, B. J. Mangan, A. Díez, J. L. Cruz, D. F. Murphy, Opt. Express 2012, 20(13), 13996.
10.1364/OE.20.013996
CAS PubMed Web of Science® Google Scholar
22H. Latifi, M. I. Zibaii, S. M. Hosseini, P. Jorge, Photonic. Sens. 2012, 2(4), 340.
10.1007/s13320-012-0086-z
CAS Google Scholar
23M. Pospíšilová, G. Kuncová, J. Trögl, Sensors 2015, 15(10), 25208.
10.3390/s151025208
CAS Web of Science® Google Scholar
24G. Y. Chen, M. Ding, T. P. Newson, G. Brambilla, Open Opt. J. 2013, 7, 32.
10.2174/1874328501307010032
CAS Google Scholar
25P. Wang, G. Brambilla, M. Ding, T. Lee, L. Bo, Y. Semenova, Q. Wu, G. Farrell, IEEE Sens. J. 2013, 13(1), 180.
10.1109/JSEN.2012.2216865
Web of Science® Google Scholar
26S. Mas, J. Martí, D. Monzón-Hernández, J. Palací, Opt. Commun. 2016, 361, 99.
10.1016/j.optcom.2015.10.025
CAS Web of Science® Google Scholar
27J. Kou, J. Feng, Q. Wang, F. Xu, Y. Lu, Opt. Lett. 2010, 35(13), 2308.
10.1364/OL.35.002308
PubMed Web of Science® Google Scholar
28J. Wo, G. Wang, Y. Cui, Q. Sun, R. Liang, P. P. Shum, D. Liu, Opt. Lett. 2012, 37(1), 67.
10.1364/OL.37.000067
PubMed Web of Science® Google Scholar
29P. Lu, J. Harris, X. Wang, G. Lin, L. Chen, X. Bao, Appl. Optics 2012, 51(30), 7368.
10.1364/AO.51.007368
CAS PubMed Web of Science® Google Scholar
30J. Musayev, Y. Adlgüzel, H. Külah, S. Eminoglu, T. Akln, IEEE Sens. J. 2014, 14(5), 1608.
10.1109/JSEN.2014.2301693
CAS Web of Science® Google Scholar
31M. R. K. Soltanian, A. S. Sharbirin, M. M. Ariannejad, I. S. Amiri, R. M. De La Rue, G. Brambilla, B. M. A. Rahman, K. T. V. Grattan, H. Ahmad, IEEE Sens. J. 2016, 16(15), 5987.
10.1109/JSEN.2016.2573961
CAS Web of Science® Google Scholar
32H. S. Haddock, P. M. Shankar, R. Mutharasan, Sens. Actuators B 2003, 88(1), 67.
10.1016/S0925-4005(02)00310-6
CAS Web of Science® Google Scholar
33Y. Tian, W. Wang, N. Wu, X. Zou, X. Wang, Sensors 2011, 11(4), 3780.
10.3390/s110403780
CAS Web of Science® Google Scholar
34G. J. Wang, Z. Bin Wang, Appl. Mech. Mater. 2014, 687–691, 3403.
10.4028/www.scientific.net/AMM.687-691.3403
CAS Google Scholar
35T. K. Yadav, R. Narayanaswamy, M. H. Abu Bakar, Y. M. Kamil, M. A. Mahdi, Opt. Express 2014, 22(19), 22802.
10.1364/OE.22.022802
CAS PubMed Web of Science® Google Scholar
36D. Liu, A. K. Mallik, J. Yuan, C. Yu, G. Farrel, Y. Semenova, Q. Wu, Opt. Lett. 2015, 40(17), 4166.
10.1364/OL.40.004166
CAS PubMed Web of Science® Google Scholar
37S. C. Warren-Smith, T. M. Monro, Opt. Express 2014, 22(2), 1480.
10.1364/OE.22.001480
CAS PubMed Web of Science® Google Scholar
38Y. Liu, C. Meng, A. P. Zhang, Y. Xiao, H. Yu, L. Tong, Opt. Lett. 2011, 36, 3115(16), 3117.
Google Scholar
39A. Candiani, M. Sozzi, A. Cucinotta, S. Selleri, R. Veneziano, R. Corradini, R. Marchelli, P. Childs, S. Pissadakis, IEEE J. Sel. Top. Quantum Electron. 2012, 18(3), 1176.
10.1109/JSTQE.2011.2166110
CAS Web of Science® Google Scholar
40Y. Huang, B. Yu, T. Guo, B. Guan, RSC Adv. 2017, 7(22), 13177.
10.1039/C7RA00170C
CAS Web of Science® Google Scholar
41S. Pilevar, C. C. Davis, F. Portugal, Anal. Chem. 1998, 70(10), 2031.
10.1021/ac9709965
CAS PubMed Web of Science® Google Scholar
42Y. Mustapha Kamil, M. H. Abu Bakar, M. A. Mustapa, M. H. Yaacob, N. H. Z. Abidin, A. Syahir, H. J. Lee, M. A. Mahdi, Sens. Actuators B 2008, 257, 820.
10.1016/j.snb.2017.11.005
Web of Science® Google Scholar
43T. Reynolds, M. R. Henderson, A. François, N. Riesen, J. M. M. Hall, S. V. Afshar, S. J. Nicholls, T. M. Monro, Opt. Express 2015, 23(13), 17067.
10.1364/OE.23.017067
CAS PubMed Web of Science® Google Scholar
44A. François, N. Riesen, H. Ji, S. V. Afshar, T. M. Monro, Appl. Phys. Lett. 2015, 106(3), 31104.
10.1063/1.4905931
CAS Web of Science® Google Scholar
45Y. Mustapha Kamil, M. H. Abu Bakar, M. A. Mustapa, M. H. Yaacob, A. Syahir, M. A. Mahdi, IEEE Photonics J. 2015, 7(6), 3700109.
10.1109/JPHOT.2015.2490486
Web of Science® Google Scholar
46M. D. Sonawane, S. B. Nimse, J. Chem. 2016, 2016, 1.
10.1155/2016/9241378
Web of Science® Google Scholar
47Y. Maruyama, S. Terao, K. Sawada, Biosens. Bioelectron. 2009, 24(10), 3108.
10.1016/j.bios.2009.03.031
CAS PubMed Web of Science® Google Scholar
48E. Özkumur, S. Ahn, A. Yalcın, C. A. Lopez, E. Cevik, R. J. Irani, C. DeLisi, M. Chiari, M. Selim Ünlü, Biosens. Bioelectron. 2010, 25(7), 1789.
10.1016/j.bios.2009.12.032
PubMed Web of Science® Google Scholar
49Q. Wang, B. Zhang, X. Lin, W. Weng, Sens. Actuators B 2011, 156(2), 599.
10.1016/j.snb.2011.02.004
CAS Web of Science® Google Scholar
50Z. Qiang, L. Junyang, Y. Yanling, G. Libo, X. Chenyang, Optik 2014, 125, 4614.
10.1016/j.ijleo.2014.05.033
CAS Web of Science® Google Scholar
51D. Sun, Y. Ran, G. Wang, Sensors 2017, 17(2559), 1.
Google Scholar
52S. Pal, M. J. Kim, J. M. Song, Lab. Chip 2008, 8, 1332.
10.1039/b804066d
CAS PubMed Web of Science® Google Scholar
53Z. Zhang, F. Hua, T. Liu, Y. Zhao, J. Li, R. Yang, C. Yang, L. Zhou, PLoS One 2014, 9(5), 1.
Google Scholar
54A. J. S. Ribeiro, K. Zaleta-rivera, E. A. Ashley, B. L. Pruitt, ACS Appl. Mater. Interfaces 2014, 6, 15516.
10.1021/am5042324
CAS PubMed Web of Science® Google Scholar
55H. H. Lin, I. Wang, P. Yen, H. Cheng, H. Tsai, H. Liao, S. Lu, F. Chou, C. Lin, Procedia Eng. 2014, 87, 340.
10.1016/j.proeng.2014.11.752
CAS Google Scholar
56W. Lai, C. Lin, Y. Yang, M. S. C. Lu, Biosens. Bioelectron. 2012, 35(1), 456.
10.1016/j.bios.2012.02.049
CAS PubMed Web of Science® Google Scholar
57M. Chuang, C. Liu, M. Yang, Sens. Actuators B 2006, 114(1), 357.
10.1016/j.snb.2005.06.001
CAS Web of Science® Google Scholar
58P. Sonthayanon, W. Chierakul, V. Wuthiekanun, J. Thaipadungpanit, T. Kalambaheti, S. Boonsilp, P. Amornchai, L. D. Smythe, D. Limmathurotsakul, N. P. Day, S. J. Peacock, Am. J. Trop. Med. Hyg. 2011, 84(4), 614.
10.4269/ajtmh.2011.10-0473
CAS PubMed Web of Science® Google Scholar
59M. Kaisti, A. Kerko, E. Aarikka, P. Saviranta, Z. Boeva, T. Soukka, A. Lehmusvuori, Sci. Rep. 2017, 7(1), 1.
10.1038/s41598-017-16028-7
CAS PubMed Web of Science® Google Scholar
60A. Karimizefreh, P. Sasanpour, E. Jokar, R. Mohammadpour, M. Vaezjalali, T. Tekieh, IEEE Int. Sci. Conf. Electron. Nanotechnol. 2014, 34, 368.
Google Scholar
61N. Oliveira, E. Souza, D. Ferreira, D. Zanforlin, W. Bezerra, M. Amélia Borb, M. Arruda, K. Lopes, G. Nascimento, D. Martins, M. Cordeiro, J. Lima-Filho, Sensors 2015, 15(7), 15562.
10.3390/s150715562
CAS Web of Science® Google Scholar
62X. Wang, H. J. Lim, A. Son, Environ. Health Toxicol. 2014, 29, 1.
10.5620/eht.2014.29.e2014007
Google Scholar
63D. S. Campos-Ferreira, E. V. M. Souza, G. A. Nascimento, D. M. L. Zanforlin, M. S. Arruda, M. F. S. Beltrao, A. L. Melo, D. Bruneska, J. L. Lima-Filho, Arabian J. Chem. 2016, 9(3), 443.
10.1016/j.arabjc.2014.05.023
CAS Web of Science® Google Scholar
64C. Ignac, DNA Engineered Noble Metal Nanoparticles, Wiley-Scrivener: Beverly, MA, 2015.
Google Scholar
65R. Sinden, DNA Structure and Function, Elsevier: Amsterdam, 2012.
Google Scholar
66T. Martan, J. Kanka, I. Kasik, V. Matejec, Int. J. Optomech. 2009, 3(3), 233.
10.1080/15599610903174457
Web of Science® Google Scholar
67M. Ahmad, L. L. Hench, Biosens. Bioelectron. 2005, 20(7), 1312.
10.1016/j.bios.2004.04.026
CAS PubMed Web of Science® Google Scholar
68M. I. Zibaii, H. Latifi, M. Karami, M. Gholami, S. M. Hosseini, M. H. Ghezelayagh, Meas. Sci. Technol. 2010, 21(10), 1.
10.1088/0957-0233/21/10/105801
Web of Science® Google Scholar
69T. K. Yadav, M. A. Mustapa, M. H. Abu Bakar, M. A. Mahdi, J. Europ. Opt. Soc. Rap. Public. 2014, 9(14024), 1.
10.2971/jeos.2014.14024
Web of Science® Google Scholar
70R. M. Pasternack, S. R. Amy, Y. J. Chabal, Langmuir 2008, 24(9), 12963.
10.1021/la8024827
CAS PubMed Web of Science® Google Scholar
71I. Migneault, C. Dartiguenave, M. J. Bertrand, K. C. Waldron, Biotechniques 2004, 37(5), 790.
10.2144/04375RV01
CAS PubMed Web of Science® Google Scholar
72X. Liu, Z. Ma, J. Xing, H. Liu, J. Magn, Magn. Mater. 2004, 270, 1.
10.1016/j.jmmm.2003.07.006
CAS Web of Science® Google Scholar
73S. Wickramaratne, S. Mukherjee, P. W. Villalta, O. D. Scharer, N. Y. Tretyakova, Bioconjug. Chem. 2013, 24, 1496.
10.1021/bc400018u
CAS PubMed Web of Science® Google Scholar
74A. Urrutia, J. Goicoechea, F. J. Arregui, J. Sens. 2015, 2015, 1.
10.1155/2015/805053
Web of Science® Google Scholar
75C. Lee, W. Shih, J. Hsu, J. Horng, Opt. Express 2014, 22(20), 24646.
10.1364/OE.22.024646
PubMed Web of Science® Google Scholar
76S. Sudheer, Doctor of Philosophy, Duke University, Durham, NC 2007.
Google Scholar
77S. C. Presnell, in The Molecular Basis of Human Cancer, edited by W. B. Coleman and G. J. Tsongalis (Springer Science+Business Media, New York, 2002, Ch. 2).
Google Scholar
78M. Yin, C. Wu, L. Shao, W. K. E. Chan, A. P. Zhang, C. Lu, H. Tam, Analyst 2013, 138, 1988.
10.1039/c3an36791f
CAS PubMed Web of Science® Google Scholar
79S. Gao, L. Sun, J. Li, L. Jin, Y. Ran, Y. Huang, B. Guan, Opt. Express 2017, 25(11), 13305.
10.1364/OE.25.013305
CAS PubMed Web of Science® Google Scholar
80Y. Huang, Z. Tian, L. Sun, D. Sun, J. Li, Y. Ran, B. Guan, Opt. Express 2015, 23(21), 26962.
10.1364/OE.23.026962
CAS PubMed Web of Science® Google Scholar
81D. Sun, T. Guo, Y. Ran, Y. Huang, B. Guan, Biosens. Bioelectron. 2014, 61, 541.
10.1016/j.bios.2014.05.065
CAS PubMed Web of Science® Google Scholar
82J. Thavanathan, N. M. Huang, K. L. Thong, Biosens. Bioelectron. 2014, 55, 91.
10.1016/j.bios.2013.11.072
CAS PubMed Web of Science® Google Scholar
83H. S. Stoker, Organic and Biological Chemistry, Cengage Learning: Boston, 2011.
Google Scholar
84T. Tian, Z. M. LeJeune, W. K. Serem, J. Yu, J. C. Garno, in Tip-Based Nanofabrication (Ed: A. A. Tseng), Springer Science+Business Media, New York 2011.
10.1007/978-1-4419-9899-6_5
Google Scholar
85B. Schneider, H. M. Berman, in Computational Studies of RNA and DNA (Eds: J. Šponer, F. Lankaš), Springer, Netherlands 2006.
Google Scholar
86X. Wang, K. L. Cooper, A. Wang, J. Xu, Z. Wang, Y. Zhang, Z. T. Virginia, Appl. Phys. Lett. 2006, 89(163901), 1.
Google Scholar
87X. Yang, K. Yang, X. Zhao, Z. Lin, Z. Liu, S. Luo, Y. Zhang, Y. Wang, W. Fu, Analyst 2017, 142(24), 4661.
10.1039/C7AN01438D
CAS PubMed Web of Science® Google Scholar
88W. J. Parak, T. Pellegrino, C. M. Micheel, D. Gerion, S. C. Williams, A. P. Alivisatos, Nano Lett. 2003, 3(1), 33.
10.1021/nl025888z
CAS Web of Science® Google Scholar
89R. Peltomaa, S. Vaghini, B. Patiño, E. Benito-Peña, M. C. Moreno-Bondi, Anal. Chim. Acta 2016, 935, 231.
10.1016/j.aca.2016.06.009
CAS PubMed Web of Science® Google Scholar
90A. J. Haes, L. Chang, W. L. Klein, R. P. Van Duyne, J. Am, Chem. Soc. 2005, 127(7), 2264.
10.1021/ja044087q
CAS PubMed Web of Science® Google Scholar
91J. Escorihuela, M. J. Bañuls, R. Puchades, Á. Maquieira, Bioconjug. Chem. 2012, 23(10), 2121.
10.1021/bc300333a
CAS PubMed Web of Science® Google Scholar
92X. Liu, W. Tan, Anal. Chem. 1999, 71(22), 5054.
10.1021/ac990561c
CAS PubMed Web of Science® Google Scholar

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Volume11, Issue8

Special Issue:Special Topic: Photonics meets Lymphatics

August 2018

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Sensitive Leptospira DNA detection using tapered optical fiber sensor

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Sensitive Leptospira DNA detection using tapered optical fiber sensor

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