Volume 33, Issue 6 pp. 757-759
ENIGMA PORTAL

Now you see me, now you don't: Isolated central nervous system recurrence of CD19-negative diffuse large B-cell lymphoma following CD19-directed CAR T-cell treatment

Hamza N. Gokozan

Hamza N. Gokozan

Division of Cytopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, New York, USA

Search for more papers by this author
Madhu M. Ouseph

Madhu M. Ouseph

Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, New York, USA

Search for more papers by this author
Jose V. Scarpa Carniello

Jose V. Scarpa Carniello

Division of Cytopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, New York, USA

Search for more papers by this author
Koen Van Besien

Koen Van Besien

Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, New York, USA

Search for more papers by this author
Sanjay S. Patel

Corresponding Author

Sanjay S. Patel

Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, New York, USA

Correspondence

Sanjay S. Patel, Division of Hematopathology, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, NY 10065, USA.

Email: [email protected]

Search for more papers by this author
First published: 17 June 2022

Graphical Abstract

The authors discuss a case of CD19-negative diffuse large B-cell lymphoma with central nervous system relapse following CD19-directed CAR T-cell treatment. Absence of CD19 expression by the tumour cells presented a challenge for flow cytometry evaluation.

CONFLICT OF INTEREST

The authors report there are no competing interests to declare. Submitting author (Hamza Gokozan) is eligible for the Mina Desai Early Career Investigator Award.

DATA AVAILABILITY STATEMENT

Data sharing is not applicable to this article as no new data were created or analysed in this study.

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.