Association of TG/HDLC ratio trajectory and risk of type 2 diabetes: A retrospective cohort study in China
TG/HDL-C比值变化轨迹与2型糖尿病发病风险的关系:一项中国回顾性队列研究
Yanyan Zhang
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorPei Qin
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorYanmei Lou
Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, People's Republic of China
Search for more papers by this authorPing Zhao
Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, People's Republic of China
Search for more papers by this authorXue Li
Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, People's Republic of China
Search for more papers by this authorRanran Qie
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorXiaoyan Wu
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorMinghui Han
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorShengbing Huang
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorYang Zhao
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorDechen Liu
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorYuying Wu
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorYang Li
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorXingjin Yang
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorYang Zhao
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorYifei Feng
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorChangyi Wang
Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China
Search for more papers by this authorJianping Ma
Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China
Search for more papers by this authorXiaolin Peng
Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China
Search for more papers by this authorHongen Chen
Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China
Search for more papers by this authorDan Zhao
Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China
Search for more papers by this authorShan Xu
Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China
Search for more papers by this authorLi Wang
Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China
Search for more papers by this authorXinping Luo
School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorMing Zhang
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorDongsheng Hu
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorCorresponding Author
Fulan Hu
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Correspondence
Fulan Hu, Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China.
Email: [email protected]
Search for more papers by this authorYanyan Zhang
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorPei Qin
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorYanmei Lou
Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, People's Republic of China
Search for more papers by this authorPing Zhao
Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, People's Republic of China
Search for more papers by this authorXue Li
Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, People's Republic of China
Search for more papers by this authorRanran Qie
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorXiaoyan Wu
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorMinghui Han
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorShengbing Huang
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorYang Zhao
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorDechen Liu
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorYuying Wu
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorYang Li
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorXingjin Yang
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorYang Zhao
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorYifei Feng
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China
Search for more papers by this authorChangyi Wang
Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China
Search for more papers by this authorJianping Ma
Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China
Search for more papers by this authorXiaolin Peng
Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China
Search for more papers by this authorHongen Chen
Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China
Search for more papers by this authorDan Zhao
Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China
Search for more papers by this authorShan Xu
Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China
Search for more papers by this authorLi Wang
Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, People's Republic of China
Search for more papers by this authorXinping Luo
School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorMing Zhang
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorDongsheng Hu
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Search for more papers by this authorCorresponding Author
Fulan Hu
Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, People's Republic of China
Correspondence
Fulan Hu, Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China.
Email: [email protected]
Search for more papers by this authorFunding information: Medical Research Foundation of Guangdong Province, Grant/Award Number: A2017181; Nanshan Science and Technology Innovation Bureau, Grant/Award Number: 2017057; National Natural Science Foundation of China, Grant/Award Numbers: 81373074, 81402752, 81673260; Natural Science Foundation of Guangdong Province, Grant/Award Number: 2017A030313452; Sanming Project of Medicine in NanShan district; Sanming Project of Medicine in Shenzhen, Grant/Award Number: SZSM201803080; Science and Technology Development Foundation of Shenzhen, Grant/Award Numbers: CYJ20140418091413562, JCYJ20160307155707264, JCYJ2
Abstract
enBackground
The association of ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C ratio) change trajectory with risk of type 2 diabetes mellitus (T2DM) remains unknown. The aim of this study was to evaluate the association between risk of T2DM and TG/HDL-C ratio change trajectory.
Methods
A total of 18 444 participants aged 18-80 years old were included in this cohort study. Linear regression and quadratic regression models were used to determine the TG/HDL-C ratio change trajectory. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between TG/HDL-C ratio change trajectory and probability of T2DM.
Results
T2DM developed in 714 participants during a median follow-up of 5.74 years (92 076.23 person-years of follow-up). After adjusting for baseline potential confounders, odds of T2DM were greater for participants with the increasing, U-shape, bell-shape, and other shape change vs decreasing change (adjusted OR [aOR] 2.01, 95% CI 1.42-2.81; 1.56, 1.15-2.13; 1.60, 1.17-2.20; and 1.49, 1.13-2.00, respectively). The results were robust in the sensitivity analyses on excluding baseline participants with T2DM. Moreover, the associations remained significant with male sex, age <60 years and body mass index <24 kg/m2.
Conclusions
This retrospective study revealed increased probability of T2DM with increasing, U-shape, bell-shape, and other-shape TG/HDL-C ratio change trajectories, especially with male sex, age <60 years and body mass index <24 kg/m2.
摘要
zh背景
三酰甘油与高密度脂蛋白胆固醇比值(Triglyceride/High-density Lipoprotein Cholesterol ratio, TG/HDL-C比值)变化轨迹与2型糖尿病(Type 2 Diabetes, T2DM)发病风险之间的关系尚不清楚。本研究旨在评估T2DM发病风险与TG/HDL-C比值变化轨迹之间的关系。
方法
该研究共纳入18444名18-80岁的研究对象, 使用线性回归和二次回归模型拟合TG/HDL-C比值变化轨迹。运用logistic回归估计TG/HDL-C比值变化轨迹与T2DM发病关联的比值比(Odds ratio, OR)和95%置信区间(Confidence Interval, CI)。
结果
在中位随访5.74年(92076.23人年)期间, 714名研究对象发生了T2DM。校正基线潜在混杂因素后, 与TG/HDL-C比值降低组相比, 增高组、U型组、钟形组和其他组T2DM的发病风险更高, 其OR和95%CI分别为:2.01, 1.42-2.81, 1.56, 1.15-2.13, 1.60, 1.17-2.20, 1.49, 1.13-2.00)。排除基线T2DM患者的敏感性分析结果依然稳定。此外, 该关联在男性、年龄<60岁和体重指数<24 kg/m2人群中仍然显著。
结论
该回顾性研究提示, 与TG/HDL-C比值降低组相比, 增高组、U型组、钟形组和其他组T2DM的发病风险增加, 尤其是在男性、年龄<60岁及体重指数<24 kg / m2人群中关联更为显著。
Supporting Information
| Filename | Description |
|---|---|
| jdb13123-sup-0001-Supinfo.docxWord 2007 document , 95.1 KB | Table S1. Characteristics at baseline by follow-up outcomes. Table S2. Association between TG, HDL-C change trajectory, and risk of T2DM. Table S3. T2DM incidence by TG/HDL-C ratio change trajectory stratified by sex, age, and BMI. Table S4. Distribution by cumulative average, SD, end-stage and annual increasing rate of TG/HDLC ratio during 2009-2016 stratified by sex, age, and BMI. Table S5. Distribution of participants in different TG/HDL-C ratio change trajectories by maximum, minimum and annual increasing rate of TG/HDL-C level. Figure S1. Example graphs of triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) ratio change trajectory patterns. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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