Serum fetuin-B is positively associated with intrahepatic triglyceride content and increases the risk of insulin resistance in obese Chinese adults: A cross-sectional study
在中国肥胖成年人中血清胎球蛋白B水平与肝内甘油三酯含量呈正相关并增加胰岛素抵抗风险:一项横断面研究
Abstract
enBackground
Fetuin-B impairs insulin action in myotubes and hepatocytes and causes glucose intolerance in mice. This study explored the correlation between serum fetuin-B and intrahepatic triglyceride (IHTG) content, and the association between fetuin-B and the risk of insulin resistance in the general adult population.
Methods
A cross-sectional study of 1318 obese adults who underwent serum fetuin-B testing and hepatic ultrasonography was conducted in Xiamen, China. The IHTG content was determined in 428 subjects by magnetic resonance spectroscopy.
Results
Non-alcoholic fatty liver disease prevalence was significantly higher in those with the highest serum fetuin-B concentrations and the highest IHTC content (Tertile 3) than in subjects in Tertiles 1 and 2 (62.6% vs 60.7% and 54.3%, respectively [P = 0.032], and 15.3% vs 12.8% and 12.7%, respectively [P = 0.049]). There was a significant association between increasing serum fetuin-B tertiles and both increasing fasting insulin concentrations (mean [± SD] 11.9 ± 6.8, 12.7 ± 7.6, and 13.3 ± 6.4 mIU/L in Tertiles 1, 2 and 3, respectively; P = 0.006) and prevalence of insulin resistance (54.4%, 58.9%, and 64.5% in Tertiles 1, 2 and 3, respectively; P = 0.010). In linear regression analysis, IHTG content was independently and positively correlated with serum fetuin-B (regression coefficient 0.015; P = 0.045). With adjustment for potential confounders, serum fetuin-B was independently associated with increased risk of insulin resistance, with an adjusted odds ratio per standard deviation increase in fetuin-B of 1.14 (95% confidence interval 1.01–1.30; P = 0.031).
Conclusions
The results demonstrate the role of fetuin-B linking liver fat accumulation to insulin resistance in humans.
摘要
zh背景
以往研究发现在小鼠中胎球蛋白B(Fetuin-B)可以损害肌管和肝细胞的胰岛素活性并且引起葡萄糖不耐受。本研究旨在普通成年人群中探讨血清Fetuin-B水平与肝内甘油三酯(intrahepatic triglyceride, IHTG)含量的关系, 以及Fetuin-B与胰岛素抵抗之间的关系。
方法
在中国厦门对1318名肥胖的成年人进行了横断面调查, 主要包括血清Fetuin-B水平的检测和肝脏超声检查, 以及对其中428名成年人利用核磁共振进行IHTG含量的测量。
结果
处于血清Fetuin-B水平最高三分位(患病率分别为62.6% v.s. 60.7%和54.3%, P = 0.032)以及IHTC含量最高三分位(患病率分别为15.3% v.s. 12.8%和12.7%, P = 0.049)的参与者中非酒精性脂肪肝的患病率显著高于第一和第二分位的参与者。随着血清Fetuin-B三分位水平的增加, 空腹胰岛素浓度(mean [±SD], 三个分位分别是11.9(± 6.8)、12.7(± 7.6)和13.3(± 6.4)mIU/L, P = 0.006)和胰岛素抵抗的患病率(三个分位分别是54.4%、58.9%和64.5%, P = 0.010)也都显著增加。线性回归分析发现IHTG含量与血清Fetuin-B水平呈独立正相关(标准回归系数:0.015, P = 0.045)。在校正可能的混杂因素后, 血清Fetuin-B水平与胰岛素抵抗风险的增加呈独立相关, 随着Fetuin-B水平每增加一个标准差, 发生胰岛素抵抗风险的比值比(OR)校正后为1.14(95%可信区间为1.01-1.30, P = 0.031)。
结论
结果表明Fetuin-B可能在肝脏脂肪累积与胰岛素抵抗中起到连接作用。
