Effect of blue light on the cell viability of A549 lung cancer cells and investigations into its possible mechanism
Hui Jiang
Academy for Engineering and Technology, Fudan University, Shanghai, China
Zhongshan Fudan Joint Innovation Center, Zhongshan, China
Search for more papers by this authorHaokuan Qin
Academy for Engineering and Technology, Fudan University, Shanghai, China
Search for more papers by this authorMiao Sun
School of Information Science and Technology, Fudan University, Shanghai, China
Search for more papers by this authorShangfei Lin
Academy for Engineering and Technology, Fudan University, Shanghai, China
Zhongshan Fudan Joint Innovation Center, Zhongshan, China
Search for more papers by this authorJiali Yang
Zhongshan Fudan Joint Innovation Center, Zhongshan, China
School of Information Science and Technology, Fudan University, Shanghai, China
Search for more papers by this authorCorresponding Author
Muqing Liu
Academy for Engineering and Technology, Fudan University, Shanghai, China
Zhongshan Fudan Joint Innovation Center, Zhongshan, China
Correspondence
Muqing Liu, Academy for Engineering and Technology, Fudan University, China.
Email: [email protected]
Search for more papers by this authorHui Jiang
Academy for Engineering and Technology, Fudan University, Shanghai, China
Zhongshan Fudan Joint Innovation Center, Zhongshan, China
Search for more papers by this authorHaokuan Qin
Academy for Engineering and Technology, Fudan University, Shanghai, China
Search for more papers by this authorMiao Sun
School of Information Science and Technology, Fudan University, Shanghai, China
Search for more papers by this authorShangfei Lin
Academy for Engineering and Technology, Fudan University, Shanghai, China
Zhongshan Fudan Joint Innovation Center, Zhongshan, China
Search for more papers by this authorJiali Yang
Zhongshan Fudan Joint Innovation Center, Zhongshan, China
School of Information Science and Technology, Fudan University, Shanghai, China
Search for more papers by this authorCorresponding Author
Muqing Liu
Academy for Engineering and Technology, Fudan University, Shanghai, China
Zhongshan Fudan Joint Innovation Center, Zhongshan, China
Correspondence
Muqing Liu, Academy for Engineering and Technology, Fudan University, China.
Email: [email protected]
Search for more papers by this authorAbstract
Blue light has attracted extensive attention as a new potential cancer therapy. Recent studies have indicated that blue light has a significant inhibition effect on A459 cells. However, the effect of light parameters on the treatment of A549 cells and the mechanism of how blue light made the effect was still unclear. This study aimed to investigate A549 cells responses to blue light with varying irradiance and dose-dense, and tried to find out the mechanism of the effects blue light made. The results suggested that the responses of A549 cells to blue light with different irradiance and dose-dense were different and the decrease of cell viability reached saturation when the irradiance reached 3 mW/cm2 and the dose-dense reached 3.6 J/cm2. It was assumed that blue light suppressed PI3K/AKT pathway and promoted the expression of JNK and p53 to affect the proliferation of A549 cells.
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