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Vascular disrupting agents (VDAs) can be used to damage the tumour vasculature, suppressing oxygen and nutrition supply to the tumour tissue. Photoacoustic imaging was used to assess the structural and functional changes of the tumour vasculature and evaluate the efficacy of the VDAs. Tissues are irradiated with short laser pulses and the photoacoustic waves are analyzed to extract vessel size and hemoglobin composition to evaluate the VDA, hours after administration.

Further details can be found in the article by Muhannad N Fadhel, Sila Appak Baskoy, Yanjie Wang, Eno Hysi, and Michael C. Kolios (e202000209).