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Optical Coherence Tomography angiography (OCTA) is widely used to image chorioretinal vasculature, with contrast that derives from scattering and motion of red blood cells (RBCs). In the rat eye, a scattering tracer highlights vertical vessels which are not visualized by intrinsic RBC scattering alone. The dependence of microvessel OCTA on angular orientation, explored in this work, represents a potential artifact that should be considered in the clinical interpretation of OCTA.

Further details can be found in the article by Jun Zhu, Marcel T. Bernucci, Conrad W. Merkle, and Vivek J. Srinivasan (e202000090).