Cover Picture: Semaglutide to remodel mitochondrial dynamics and mitophagy balance for vascular dementia therapy (View 3/2025)
Graphical Abstract
Semaglutide maintained the balance of mitochondrial dynamics and mitophagy by improving insulin resistance and passing through GLP-1R/PI3K/Akt pathway, reduced hippocampal neuroinflammation and neuron loss, and thus promoted the recovery of cognitive function in bilateral common carotid artery stenosis (BCAS) mouse model of VaD.