• Issue
    2011
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Research Article
Open Access

Alzheimer′s Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System

Chris Carter, 
  • First Published: 29 December 2011
Review Article
Open Access

Modelling Tauopathies in Drosophila: Insights from the Fruit Fly

Catherine M. Cowan,  Megan A. Sealey,  Shmma Quraishe,  Marie-Therese Targett,  Kristen Marcellus,  Douglas Allan,  Amritpal Mudher, 
  • First Published: 29 December 2011
Editorial
Open Access

Copper Status in Alzheimer′s Disease and Other Neurodegenerative Disorders: Genetics, Mechanisms, Neurophysiology, and Therapies

Rosanna Squitti,  D. Larry Sparks,  Tjaard U. Hoogenraad,  George J. Brewer, 
  • First Published: 15 December 2011
Editorial
Open Access

Glycogen Synthase Kinase-3

Peter Crouch,  Adam Cole,  Michael Cousin,  Ana Martinez,  Katja Kanninen, 
  • First Published: 11 December 2011
Review Article
Open Access

Genetics of Late-Onset Alzheimer′s Disease: Update from the Alzgene Database and Analysis of Shared Pathways

Paolo Olgiati,  Antonis M. Politis,  George N. Papadimitriou,  Diana De Ronchi,  Alessandro Serretti, 
  • First Published: 10 December 2011
Review Article
Open Access

Diagnostic Utility of CSF Tau and Aβ42 in Dementia: A Meta-Analysis

Rachna Agarwal,  Chandra Bhushan Tripathi, 
  • First Published: 04 December 2011
Research Article
Open Access

On the Involvement of Copper Binding to the N-Terminus of the Amyloid Beta Peptide of Alzheimer′s Disease: A Computational Study on Model Systems

Samira Azimi,  Arvi Rauk, 
  • First Published: 01 December 2011
Clinical Study
Open Access

Evidence for Elevated Cerebrospinal Fluid ERK1/2 Levels in Alzheimer Dementia

Philipp Spitzer,  Heinke Schieb,  Heike Kamrowski-Kruck,  Markus Otto,  Davide Chiasserini,  Lucilla Parnetti,  Sanna-Kaisa Herukka,  Johannes Schuchhardt,  Jens Wiltfang,  Hans-Wolfgang Klafki, 
  • First Published: 24 November 2011
Research Article
Open Access

Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and Ceruloplasmin

Franca Tecchio,  Giovanni Assenza,  Filippo Zappasodi,  Stefania Mariani,  Carlo Salustri,  Rosanna Squitti, 
  • First Published: 21 November 2011
Review Article
Open Access

Disturbed Copper Bioavailability in Alzheimer′s Disease

Daniela Kaden,  Ashley I. Bush,  Ruth Danzeisen,  Thomas A. Bayer,  Gerd Multhaup, 
  • First Published: 15 November 2011
Editorial
Open Access

Early Clinical and Molecular Detection of Alzheimer′s Disease

Benedetta Nacmias,  Christiane Reitz,  Thomas Arendt, 
  • First Published: 10 November 2011
Review Article
Open Access

Detection of Soluble Amyloid-β Oligomers and Insoluble High-Molecular-Weight Particles in CSF: Development of Methods with Potential for Diagnosis and Therapy Monitoring of Alzheimer′s Disease

Susanne Aileen Funke, 
  • First Published: 02 November 2011
Review Article
Open Access

Biomarkers for Microglial Activation in Alzheimer′s Disease

Ronald Lautner,  Niklas Mattsson,  Michael Schöll,  Kristin Augutis,  Kaj Blennow,  Bob Olsson,  Henrik Zetterberg, 
  • First Published: 01 November 2011
Review Article
Open Access

Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer′s Disease: Focus on Gene Therapy and Cell-Based Therapy Applications

Tarja Malm,  Jari Koistinaho,  Katja Kanninen, 
  • First Published: 30 October 2011
Review Article
Open Access

Potential Peripheral Biomarkers for the Diagnosis of Alzheimer′s Disease

Seema Patel,  Raj J. Shah,  Paul Coleman,  Marwan Sabbagh, 
  • First Published: 23 October 2011
Review Article
Open Access

Introducing Human APOE into Aβ Transgenic Mouse Models

Leon M. Tai,  Katherine L. Youmans,  Lisa Jungbauer,  Chunjiang Yu,  Mary Jo LaDu, 
  • First Published: 19 October 2011
Research Article
Open Access

The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X4 Receptors

Ramón A. Lorca,  Lorena Varela-Nallar,  Nibaldo C. Inestrosa,  J. Pablo Huidobro-Toro, 
  • First Published: 19 October 2011
Research Article
Open Access

Gender Effects on Plasma and Brain Copper

Joseph F. Quinn,  Christopher Harris,  Jeffrey A. Kaye,  Babett Lind,  Raina Carter,  Thimmappa Anekonda,  Martina Ralle, 
  • First Published: 19 October 2011
Research Article
Open Access

Copper Inhibits NMDA Receptor-Independent LTP and Modulates the Paired-Pulse Ratio after LTP in Mouse Hippocampal Slices

Nina L. Salazar-Weber,  Jeffrey P. Smith, 
  • First Published: 19 October 2011
Review Article
Open Access

Biomarkers to Measure Treatment Effects in Alzheimer′s Disease: What Should We Look for?

Kenneth Rockwood, 
  • First Published: 18 October 2011
Research Article
Open Access

Comparison of Vascular Perturbations in an Aβ-Injected Animal Model and in AD Brain

Nattinee Jantaratnotai,  Jae K. Ryu,  Claudia Schwab,  Patrick L. McGeer,  James G. McLarnon, 
  • First Published: 29 September 2011
Clinical Study
Open Access

Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer′s Disease: Clinical and Neurochemical Correlates

Ezra Mulugeta,  Elisabet Londos,  Oskar Hansson,  Clive Ballard,  Ragnhild Skogseth,  Lennart Minthon,  Kaj Blennow,  Henrik Zetterberg,  Dag Aarsland, 
  • First Published: 28 September 2011
Review Article
Open Access

Paradigm Shift in Treatment of Alzheimer′s Disease: Zinc Therapy Now a Conscientious Choice for Care of Individual Patients

Tjaard U. Hoogenraad, 
  • First Published: 22 September 2011
Research Article
Open Access

Assessing the Sociocultural Impacts of Emerging Molecular Technologies for the Early Diagnosis of Alzheimer′s Disease

Marianne Boenink,  Yvonne Cuijpers,  Anna Laura van der Laan,  Harro van Lente,  Ellen Moors, 
  • First Published: 21 September 2011
Editorial
Open Access

New Thinking on the Etiology and Pathogenesis of Late-Onset Alzheimer′s Disease

Alan P. Hudson,  Brian J. Balin,  Keith Crutcher,  Stephen Robinson, 
  • First Published: 18 September 2011
Review Article
Open Access

Issues Raised Involving the Copper Hypotheses in the Causation of Alzheimer′s Disease

George J. Brewer, 
  • First Published: 14 September 2011
Clinical Study
Open Access

Mitochondria Are Related to Synaptic Pathology in Alzheimer′s Disease

Stavros J. Baloyannis, 
  • First Published: 12 September 2011
Research Article
Open Access

A Comparative Study of Five Mouse Models of Alzheimer′s Disease: Cell Cycle Events Reveal New Insights into Neurons at Risk for Death

Luming Li,  Timmy Cheung,  Jianmin Chen,  Karl Herrup, 
  • First Published: 08 September 2011
Review Article
Open Access

Copper Modulation as a Therapy for Alzheimer′s Disease?

Yasmina Manso,  Gemma Comes,  Juan Hidalgo,  Ashley I. Bush,  Paul A. Adlard, 
  • First Published: 23 August 2011
Research Article
Open Access

High Throughput ELISAs to Measure a Unique Glycan on Transferrin in Cerebrospinal Fluid: A Possible Extension toward Alzheimer′s Disease Biomarker Development

Keiro Shirotani,  Satoshi Futakawa,  Kiyomitsu Nara,  Kyoka Hoshi,  Toshie Saito,  Yuriko Tohyama,  Shinobu Kitazume,  Tatsuhiko Yuasa,  Masakazu Miyajima,  Hajime Arai,  Atsushi Kuno,  Hisashi Narimatsu,  Yasuhiro Hashimoto, 
  • First Published: 17 August 2011
Review Article
Open Access

Cognitive Stimulation Programs in Healthy Elderly: A Review

Sarah Tardif,  Martine Simard, 
  • First Published: 15 August 2011
Editorial
Open Access

Genetic Risk Factors: Their Function and Comorbidities in Alzheimer′s Disease

Mikko Hiltunen,  Lars Bertram,  Aleister J. Saunders, 
  • First Published: 11 August 2011
Editorial
Open Access

Clinical Neurophysiology in Alzheimer′s Disease

Florinda Ferreri,  Sara Määttä,  Fabrizio Vecchio,  Giuseppe Curcio,  Fabio Ferrarelli, 
  • First Published: 09 August 2011
Review Article
Open Access

MicroRNAs and Alzheimer′s Disease Mouse Models: Current Insights and Future Research Avenues

Charlotte Delay,  Sébastien S. Hébert, 
  • First Published: 31 July 2011
Review Article
Open Access

Caloric Intake, Dietary Lifestyles, Macronutrient Composition, and Alzheimer′ Disease Dementia

Giulio Maria Pasinetti,  Jun Wang,  Shanee Porter,  Lap Ho, 
  • First Published: 26 July 2011
Research Article
Open Access

Capacity to Vote in Persons with Dementia and the Elderly

Luis Javier Irastorza,  Pablo Corujo,  Pilar Bañuelos, 
  • First Published: 18 July 2011
Research Article
Open Access

Genetic Association between Akt1 Polymorphisms and Alzheimer′s Disease in a Japanese Population

Nobuto Shibata,  Tohru Ohnuma,  Bolati Kuerban,  Miwa Komatsu,  Hajime Baba,  Heii Arai, 
  • First Published: 14 July 2011
Clinical Study
Open Access

Evaluating Voting Competence in Persons with Alzheimer Disease

Pietro Tiraboschi,  Erica Chitò,  Leonardo Sacco,  Marta Sala,  Stefano Stefanini,  Carlo Alberto Defanti, 
  • First Published: 14 July 2011
Case Report
Open Access

An Unusual Cause of Dementia: Essential Diagnostic Elements of Corticobasal Degeneration—A Case Report and Review of the Literature

F. Mastrolilli,  A. Benvenga,  L. Di Biase,  F. Giambattistelli,  L. Trotta,  G. Salomone,  L. Quintiliani,  D. Landi,  J. M. Melgari,  F. Vernieri, 
  • First Published: 12 July 2011
Review Article
Open Access

Functional Implications of Glycogen Synthase Kinase-3-Mediated Tau Phosphorylation

Diane P. Hanger,  Wendy Noble, 
  • First Published: 11 July 2011
Research Article
Open Access

Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis

Farzaneh Modarresi,  Mohammad Ali Faghihi,  Nikunj S. Patel,  Barbara G. Sahagan,  Claes Wahlestedt,  Miguel A. Lopez-Toledano, 
  • First Published: 09 July 2011
Editorial
Open Access

Aβ Behavior on Neuronal Membranes: Aggregation and Toxicities

Katsuhiko Yanagisawa,  Jacques Fantini,  Avijit Chakrabartty,  Anne Eckert, 
  • First Published: 06 July 2011
Review Article
Open Access

Transcranial Magnetic Stimulation Studies in Alzheimer′s Disease

Andrea Guerra,  Federica Assenza,  Federica Bressi,  Federica Scrascia,  Marco Del Duca,  Francesca Ursini,  Stefano Vollaro,  Laura Trotta,  Mario Tombini,  Carmelo Chisari,  Florinda Ferreri, 
  • First Published: 06 July 2011
Review Article
Open Access

Bridging Molecular Genetics and Biomarkers in Lewy Body and Related Disorders

Gilbert J. Ho,  Willie Liang,  Masaaki Waragai,  Kazunari Sekiyama,  Eliezer Masliah,  Makoto Hashimoto, 
  • First Published: 03 July 2011
Review Article
Open Access

Glycogen Synthase Kinase 3 Inhibitors in the Next Horizon for Alzheimer′s Disease Treatment

Ana Martinez,  Carmen Gil,  Daniel I. Perez, 
  • First Published: 30 June 2011
Research Article
Open Access

Joint Assessment of Structural, Perfusion, and Diffusion MRI in Alzheimer′s Disease and Frontotemporal Dementia

Yu Zhang,  Norbert Schuff,  Christopher Ching,  Duygu Tosun,  Wang Zhan,  Marzieh Nezamzadeh,  Howard J. Rosen,  Joel H. Kramer,  Maria Luisa Gorno-Tempini,  Bruce L. Miller,  Michael W. Weiner, 
  • First Published: 27 June 2011
Research Article
Open Access

Morphological Factor Estimation via High-Dimensional Reduction: Prediction of MCI Conversion to Probable AD

Simon Duchesne,  Abderazzak Mouiha, 
  • First Published: 22 June 2011
Research Article
Open Access

Association between the c. 2495 A>G ATP7B Polymorphism and Sporadic Alzheimer′s Disease

Serena Bucossi,  Stefania Mariani,  Mariacarla Ventriglia,  Renato Polimanti,  Massimo Gennarelli,  Cristian Bonvicini,  Patrizio Pasqualetti,  Federica Scrascia,  Simone Migliore,  Fabrizio Vernieri,  Paolo M. Rossini,  Rosanna Squitti, 
  • First Published: 15 June 2011
Review Article
Open Access

The Default Mode Network in Healthy Aging and Alzheimer′s Disease

Katell Mevel,  Gaël Chételat,  Francis Eustache,  Béatrice Desgranges, 
  • First Published: 14 June 2011
Research Article
Open Access

Volumetric Differences in Mapped Hippocampal Regions Correlate with Increase of High Alpha Rhythm in Alzheimer′s Disease

D. V. Moretti,  A. Prestia,  C. Fracassi,  C. Geroldi,  G. Binetti,  P. M. Rossini,  O. Zanetti,  G. B. Frisoni, 
  • First Published: 14 June 2011
Research Article
Open Access

Alzheimer′s Disease Genes Are Associated with Measures of Cognitive Ageing in the Lothian Birth Cohorts of 1921 and 1936

Gillian Hamilton,  Sarah E. Harris,  Gail Davies,  David C. Liewald,  Albert Tenesa,  John M. Starr,  David Porteous,  Ian J. Deary, 
  • First Published: 12 June 2011
Research Article
Open Access

Fluorescent Analysis of the Cell-Selective Alzheimer′s Disease Aβ Peptide Surface Membrane Binding: Influence of Membrane Components

Olga Simakova,  Nelson J. Arispe, 
  • First Published: 08 June 2011
Research Article
Open Access

Genomic Copy Number Analysis in Alzheimer′s Disease and Mild Cognitive Impairment: An ADNI Study

Shanker Swaminathan,  Sungeun Kim,  Li Shen,  Shannon L. Risacher,  Tatiana Foroud,  Nathan Pankratz,  Steven G. Potkin,  Matthew J. Huentelman,  David W. Craig,  Michael W. Weiner,  Andrew J. Saykin,  The Alzheimer′s Disease Neuroimaging Initiative (ADNI), 
  • First Published: 02 June 2011
Research Article
Open Access

A Novel Study and Meta-Analysis of the Genetic Variation of the Serotonin Transporter Promoter in the Italian Population Do Not Support a Large Effect on Alzheimer′s Disease Risk

Letizia Polito,  Francesca Prato,  Serena Rodilossi,  Eleonora Ateri,  Daniela Galimberti,  Elio Scarpini,  Francesca Clerici,  Claudio Mariani,  Gianluigi Forloni,  Diego Albani, 
  • First Published: 02 June 2011
Clinical Study
Open Access

Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus

Ville Leinonen,  Lata G. Menon,  Rona S. Carroll,  Donna Dello Iacono,  Jeremy Grevet,  Juha E. Jääskeläinen,  Peter M. Black, 
  • First Published: 01 June 2011
Review Article
Open Access

Biomarkers of the Dementia

Mikio Shoji, 
  • First Published: 30 May 2011
Research Article
Open Access

Improving the Specificity of EEG for Diagnosing Alzheimer′s Disease

François-B. Vialatte,  Justin Dauwels,  Monique Maurice,  Toshimitsu Musha,  Andrzej Cichocki, 
  • First Published: 30 May 2011
Research Article
Open Access

Memory Awareness Influences Everyday Decision Making Capacity about Medication Management in Alzheimer′s Disease

Stephanie Cosentino,  Janet Metcalfe,  Mark S. Cary,  Jessica De Leon,  Jason Karlawish, 
  • First Published: 29 May 2011
Research Article
Open Access

Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice

Anja Brenn,  Markus Grube,  Michele Peters,  Andrea Fischer,  Gabriele Jedlitschky,  Heyo K. Kroemer,  Rolf W. Warzok,  Silke Vogelgesang, 
  • First Published: 29 May 2011
Review Article
Open Access

Increased Cerebrospinal Fluid Production as a Possible Mechanism Underlying Caffeine′s Protective Effect against Alzheimer′s Disease

Peter Wostyn,  Debby Van Dam,  Kurt Audenaert,  Peter Paul De Deyn, 
  • First Published: 26 May 2011
Research Article
Open Access

The Link between Cognitive Measures and ADLs and IADL Functioning in Mild Alzheimer′s: What has Gender Got to Do with It?

James R. Hall,  Hoa T. Vo,  Leigh A. Johnson,  Robert C. Barber,  S. E. O′Bryant, 
  • First Published: 25 May 2011
Research Article
Open Access

Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid

Cheryl A. Luis,  Laila Abdullah,  Ghania Ait-Ghezala,  Benoit Mouzon,  Andrew P. Keegan,  Fiona Crawford,  Michael Mullan, 
  • First Published: 24 May 2011
Editorial
Open Access

Genetics and Genomics of Late-Onset Alzheimer′s Disease and Its Endophenotypes

Christiane Reitz,  Ekaterina Rogaeva,  Tatiana Foroud,  Lindsay A. Farrer, 
  • First Published: 23 May 2011
Review Article
Open Access

Brain Functional Network in Alzheimer′s Disease: Diagnostic Markers for Diagnosis and Monitoring

Guido Rodriguez,  Dario Arnaldi,  Agnese Picco, 
  • First Published: 18 May 2011
Review Article
Open Access

What Are the bona fide GSK3 Substrates?

Calum Sutherland, 
  • First Published: 18 May 2011
Research Article
Open Access

Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer′s Disease

Marcus O. W. Grimm,  Sven Grösgen,  Tatjana L. Rothhaar,  Verena K. Burg,  Benjamin Hundsdörfer,  Viola J. Haupenthal,  Petra Friess,  Ulrike Müller,  Klaus Fassbender,  Matthias Riemenschneider,  Heike S. Grimm,  Tobias Hartmann, 
  • First Published: 18 May 2011
Research Article
Open Access

Combining Transcranial Magnetic Stimulation and Electroencephalography May Contribute to Assess the Severity of Alzheimer′s Disease

Petro Julkunen,  Anne M. Jauhiainen,  Mervi Könönen,  Ari Pääkkönen,  Jari Karhu,  Hilkka Soininen, 
  • First Published: 15 May 2011
Review Article
Open Access

The Use of Auditory Event-Related Potentials in Alzheimer′s Disease Diagnosis

Fabrizio Vecchio,  Sara Määttä, 
  • First Published: 14 May 2011
Review Article
Open Access

Electroencephalographic Rhythms in Alzheimer′s Disease

Roberta Lizio,  Fabrizio Vecchio,  Giovanni B. Frisoni,  Raffaele Ferri,  Guido Rodriguez,  Claudio Babiloni, 
  • First Published: 12 May 2011
Review Article
Open Access

Regulation of Cell Survival Mechanisms in Alzheimer′s Disease by Glycogen Synthase Kinase-3

Marjelo A. Mines,  Eleonore Beurel,  Richard S. Jope, 
  • First Published: 11 May 2011
Research Article
Open Access

Adenosine A2A Receptor and IL-10 in Peripheral Blood Mononuclear Cells of Patients with Mild Cognitive Impairment

Beatrice Arosio,  Luigina Mastronardi,  Cristina Gussago,  Paola Nicolini,  Alessandra Casè,  Eleonora Ziglioli,  Luigi Bergamaschini, 
  • First Published: 10 May 2011
Review Article
Open Access

Glycogen Synthase Kinase-3β: A Mediator of Inflammation in Alzheimer′s Disease?

Jari Koistinaho,  Tarja Malm,  Gundars Goldsteins, 
  • First Published: 04 May 2011
Review Article
Open Access

GSK3 Function in the Brain during Development, Neuronal Plasticity, and Neurodegeneration

Pamela Salcedo-Tello,  Abril Ortiz-Matamoros,  Clorinda Arias, 
  • First Published: 04 May 2011
Review Article
Open Access

GSK-3 in Neurodegenerative Diseases

Peng Lei,  Scott Ayton,  Ashley I. Bush,  Paul A. Adlard, 
  • First Published: 04 May 2011
Review Article
Open Access

Melatonin in Mitochondrial Dysfunction and Related Disorders

Venkatramanujam Srinivasan,  D. Warren Spence,  Seithikurippu R. Pandi-Perumal,  Gregory M. Brown,  Daniel P. Cardinali, 
  • First Published: 04 May 2011
Editorial
Open Access

Metals and Alzheimer′s Disease

Anthony R. White,  Peter Faller,  Craig S. Atwood,  Paolo Zatta, 
  • First Published: 03 May 2011
Research Article
Open Access

Does EEG Montage Influence Alzheimer′s Disease Electroclinic Diagnosis?

L. R. Trambaiolli,  A. C. Lorena,  F. J. Fraga,  P. A. M. K. Kanda,  R. Nitrini,  R. Anghinah, 
  • First Published: 02 May 2011
Review Article
Open Access

Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer′s Disease: Involvement of the Nrf2-ARE Pathway

Katja Kanninen,  Anthony R. White,  Jari Koistinaho,  Tarja Malm, 
  • First Published: 02 May 2011
Review Article
Open Access

Deconstructing GSK-3: The Fine Regulation of Its Activity

Miguel Medina,  Francisco Wandosell, 
  • First Published: 28 April 2011
Research Article
Open Access

Bioinformatics Identification of Modules of Transcription Factor Binding Sites in Alzheimer′s Disease-Related Genes by In Silico Promoter Analysis and Microarrays

Regina Augustin,  Stefan F. Lichtenthaler,  Michael Greeff,  Jens Hansen,  Wolfgang Wurst,  Dietrich Trümbach, 
  • First Published: 26 April 2011
Research Article
Open Access

Centella asiatica Attenuates D-Galactose-Induced Cognitive Impairment, Oxidative and Mitochondrial Dysfunction in Mice

Anil Kumar,  Atish Prakash,  Samrita Dogra, 
  • First Published: 19 April 2011
Review Article
Open Access

Multimodal Imaging of Alzheimer Pathophysiology in the Brain′s Default Mode Network

Jonghan Shin,  Vladimir Kepe,  Gary W. Small,  Michael E. Phelps,  Jorge R. Barrio, 
  • First Published: 19 April 2011
Research Article
Open Access

Influence of Water Quality on Cholesterol-Induced Tau Pathology: Preliminary Data

D. Larry Sparks,  Chuck Ziolkowski,  Todd Lawmaster,  Timothy Martin, 
  • First Published: 17 April 2011
Research Article
Open Access

Association Study of Genetic Variants in CDKN2A/CDKN2B Genes/Loci with Late-Onset Alzheimer′s Disease

Andrea Tedde,  Irene Piaceri,  Silvia Bagnoli,  Ersilia Lucenteforte,  Uwe Ueberham,  Thomas Arendt,  Sandro Sorbi,  Benedetta Nacmias, 
  • First Published: 14 April 2011
Research Article
Open Access

Slowing and Loss of Complexity in Alzheimer′s EEG: Two Sides of the Same Coin?

Justin Dauwels,  K. Srinivasan,  M. Ramasubba Reddy,  Toshimitsu Musha,  François-Benoît Vialatte,  Charles Latchoumane,  Jaeseung Jeong,  Andrzej Cichocki, 
  • First Published: 13 April 2011
Case Report
Open Access

Nonconvulsive Seizures and Dementia: A Case Report

Campana Chiara,  Assenza Giovanni,  Pellegrino Giovanni,  Benvenga Antonella,  Assenza Federica,  Ursini Francesca,  Vernieri Fabrizio,  Tombini Mario, 
  • First Published: 13 April 2011
Review Article
Open Access

Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer′s β-Amyloid Protein

Masahiro Kawahara,  Isao Ohtsuka,  Shoko Yokoyama,  Midori Kato-Negishi,  Yutaka Sadakane, 
  • First Published: 12 April 2011
Research Article
Open Access

MRI Shows More Severe Hippocampal Atrophy and Shape Deformation in Hippocampal Sclerosis Than in Alzheimer′s Disease

C. Zarow,  L. Wang,  H. C. Chui,  M. W. Weiner,  J. G. Csernansky, 
  • First Published: 11 April 2011
Review Article
Open Access

Magnetoencephalography as a Putative Biomarker for Alzheimer′s Disease

Edward Zamrini,  Fernando Maestu,  Eero Pekkonen,  Michael Funke,  Jyrki Makela,  Myles Riley,  Ricardo Bajo,  Gustavo Sudre,  Alberto Fernandez,  Nazareth Castellanos,  Francisco del Pozo,  C. J. Stam,  Bob W. van Dijk,  Anto Bagic,  James T. Becker, 
  • First Published: 10 April 2011
Research Article
Open Access

Lack of Association between the GPR3 Gene and the Risk for Alzheimer′s Disease

Roberto Dominici,  Marcello Ronchi,  Daniela Galimberti,  Elio Scarpini,  Dario Finazzi, 
  • First Published: 07 April 2011
Research Article
Open Access

Specific Silencing of L392V PSEN1 Mutant Allele by RNA Interference

Malgorzata Sierant,  Alina Paduszynska,  Julia Kazmierczak-Baranska,  Benedetta Nacmias,  Sandro Sorbi,  Silvia Bagnoli,  Elzbieta Sochacka,  Barbara Nawrot, 
  • First Published: 07 April 2011
Review Article
Open Access

Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late-Onset Alzheimer′s Disease: Focus on APOE Gene

Francesco Panza,  Davide Seripa,  Grazia D′Onofrio,  Vincenza Frisardi,  Vincenzo Solfrizzi,  Patrizia Mecocci,  Alberto Pilotto, 
  • First Published: 07 April 2011
Research Article
Open Access

Direction of Information Flow in Alzheimer′s Disease and MCI Patients

Fabrizio Vecchio,  Claudio Babiloni, 
  • First Published: 07 April 2011
Review Article
Open Access

Yeast as a Model System to Study Tau Biology

Ann De Vos,  Jayamani Anandhakumar,  Jeff Van den Brande,  Mathias Verduyckt,  Vanessa Franssens,  Joris Winderickx,  Erwin Swinnen, 
  • First Published: 06 April 2011
Review Article
Open Access

Management of Demented Patients in Emergency Department

Lavinia Valeriani, 
  • First Published: 05 April 2011
Review Article
Open Access

Function and Comorbidities of Apolipoprotein E in Alzheimer′s Disease

Valérie Leduc,  Dorothée Domenger,  Louis De Beaumont,  Daphnée Lalonde,  Stéphanie Bélanger-Jasmin,  Judes Poirier, 
  • First Published: 05 April 2011
Review Article
Open Access

Neuroimaging Measures as Endophenotypes in Alzheimer′s Disease

Meredith N. Braskie,  John M. Ringman,  Paul M. Thompson, 
  • First Published: 31 March 2011
Clinical Study
Open Access

Electromyographic Activity in the EEG in Alzheimer′s Disease: Noise or Signal?

Karin van der Hiele,  Robert H. A. M. Reijntjes,  Alla A. Vein,  Rudi G. J. Westendorp,  Mark A. van Buchem,  Eduard L. E. M. Bollen,  Huub A. M. Middelkoop,  J. Gert van Dijk, 
  • First Published: 29 March 2011
Research Article
Open Access

Psychosis in Alzheimer′s Disease in the National Alzheimer′s Disease Coordinating Center Uniform Data Set: Clinical Correlates and Association with Apolipoprotein E

Mary Ann A. DeMichele-Sweet,  Oscar L. Lopez,  Robert A. Sweet, 
  • First Published: 23 March 2011
Review Article
Open Access

Mitochondria, Amyloid β, and Alzheimer′s Disease

Ryan D. Readnower,  Andrew D. Sauerbeck,  Patrick G. Sullivan, 
  • First Published: 22 March 2011
Research Article
Open Access

Resting-State Glucose Metabolism Level Is Associated with the Regional Pattern of Amyloid Pathology in Alzheimer′s Disease

Jonghan Shin,  Wai Tsui,  Yi Li,  Sang-Yoon Lee,  Seog Ju Kim,  Seong-Jin Cho,  Young-Bo Kim,  Mony J. de Leon, 
  • First Published: 17 March 2011
Review Article
Open Access

Impacts of Membrane Biophysics in Alzheimer′s Disease: From Amyloid Precursor Protein Processing to Aβ Peptide-Induced Membrane Changes

Sholpan Askarova,  Xiaoguang Yang,  James C.-M. Lee, 
  • First Published: 17 March 2011
Review Article
Open Access

The Usefulness of Biological and Neuroimaging Markers for the Diagnosis of Early-Onset Alzheimer′s Disease

Alessandro Padovani,  Nicola Gilberti,  Barbara Borroni, 
  • First Published: 17 March 2011
Review Article
Open Access

Amyloid-Beta Interaction with Mitochondria

Lucia Pagani,  Anne Eckert, 
  • First Published: 15 March 2011
Research Article
Open Access

Thickness in Entorhinal and Subicular Cortex Predicts Episodic Memory Decline in Mild Cognitive Impairment

A. C. Burggren,  B. Renner,  M. Jones,  M. Donix,  N. A. Suthana,  L. Martin-Harris,  L. M. Ercoli,  K. J. Miller,  P. Siddarth,  G. W. Small,  S. Y. Bookheimer, 
  • First Published: 15 March 2011
Review Article
Open Access

The Role of GSK3 in Presynaptic Function

Karen Janet Smillie,  Michael Alan Cousin, 
  • First Published: 14 March 2011
Review Article
Open Access

Link between Aluminum and the Pathogenesis of Alzheimer′s Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses

Masahiro Kawahara,  Midori Kato-Negishi, 
  • First Published: 08 March 2011
Research Article
Open Access

Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process

Garima Thakur,  Miodrag Micic,  Yuehai Yang,  Wenzhi Li,  Dania Movia,  Silvia Giordani,  Hongzhou Zhang,  Roger M. Leblanc, 
  • First Published: 02 March 2011
Review Article
Open Access

Alzheimer′s Disease and Metals: A Review of the Involvement of Cellular Membrane Receptors in Metallosignalling

Pavithra C. Amadoruge,  Kevin J. Barnham, 
  • First Published: 02 March 2011
Research Article
Open Access

TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains

Sara Ansaloni,  Brian P. Leung,  Neeraj P. Sebastian,  Rohini Samudralwar,  Mariana Gadaleta,  Aleister J. Saunders, 
  • First Published: 24 February 2011
Review Article
Open Access

The Apolipoprotein E Antagonistic Pleiotropy Hypothesis: Review and Recommendations

Elizabeth R. Tuminello,  S. Duke Han, 
  • First Published: 24 February 2011
Review Article
Open Access

May “Mitochondrial Eve” and Mitochondrial Haplogroups Play a Role in Neurodegeneration and Alzheimer′s Disease?

Elena Caldarazzo Ienco,  Costanza Simoncini,  Daniele Orsucci,  Loredana Petrucci,  Massimiliano Filosto,  Michelangelo Mancuso,  Gabriele Siciliano, 
  • First Published: 22 February 2011
Review Article
Open Access

Possible Role of the Transglutaminases in the Pathogenesis of Alzheimer′s Disease and Other Neurodegenerative Diseases

Antonio Martin,  Giulia De Vivo,  Vittorio Gentile, 
  • First Published: 16 February 2011
Research Article
Open Access

ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function

Lia Zepa,  Moran Frenkel,  Haim Belinson,  Zehavit Kariv-Inbal,  Rakez Kayed,  Eliezer Masliah,  Daniel M. Michaelson, 
  • First Published: 15 February 2011
Review Article
Open Access

Aβ Internalization by Neurons and Glia

Amany Mohamed,  Elena Posse de Chaves, 
  • First Published: 15 February 2011
Review Article
Open Access

Amyloid Oligomer Neurotoxicity, Calcium Dysregulation, and Lipid Rafts

Fiorella Malchiodi-Albedi,  Silvia Paradisi,  Andrea Matteucci,  Claudio Frank,  Marco Diociaiuti, 
  • First Published: 08 February 2011
Research Article
Open Access

The Pathogenesis of Alzheimer′s Disease: A Reevaluation of the “Amyloid Cascade Hypothesis”

R. A. Armstrong, 
  • First Published: 07 February 2011
Research Article
Open Access

Cell Surface Binding and Internalization of Aβ Modulated by Degree of Aggregation

David A. Bateman,  Avijit Chakrabartty, 
  • First Published: 07 February 2011
Review Article
Open Access

Protein Kinase C-Regulated Aβ Production and Clearance

Taehyun Kim,  David J. Hinton,  Doo-Sup Choi, 
  • First Published: 17 January 2011
Review Article
Open Access

Formation of Toxic Amyloid Fibrils by Amyloid β-Protein on Ganglioside Clusters

Katsumi Matsuzaki, 
  • First Published: 13 January 2011
Review Article
Open Access

The Pathological Roles of Ganglioside Metabolism in Alzheimer′s Disease: Effects of Gangliosides on Neurogenesis

Toshio Ariga,  Chandramohan Wakade,  Robert K. Yu, 
  • First Published: 09 January 2011
Research Article
Open Access

Correlation of Copper Interaction, Copper-Driven Aggregation, and Copper-Driven H2O2 Formation with Aβ40 Conformation

Chia-Anne Yang,  Yung-Han Chen,  Shyue-Chu Ke,  Yi-Ru Chen,  Hsien-Bin Huang,  Ta-Hsien Lin,  Yi-Cheng Chen, 
  • First Published: 30 December 2010
Research Article
Open Access

A Factor Analytic Approach to Symptom Patterns in Dementia

Lars Gustafson,  Catarina Erikson,  Siegbert Warkentin,  Arne Brun,  Elisabet Englund,  Ulla Passant, 
  • First Published: 30 December 2010
Research Article
Open Access

Spectroscopic Characterization of Intermolecular Interaction of Amyloid β Promoted on GM1 Micelles

Maho Yagi-Utsumi,  Koichi Matsuo,  Katsuhiko Yanagisawa,  Kunihiko Gekko,  Koichi Kato, 
  • First Published: 28 December 2010
Research Article
Open Access

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate

Michael Ho,  David E. Hoke,  Yee Jia Chua,  Qiao-Xin Li,  Janetta G. Culvenor,  Colin Masters,  Anthony R. White,  Geneviève Evin, 
  • First Published: 28 December 2010
Review Article
Open Access

Lead, Manganese, and Methylmercury as Risk Factors for Neurobehavioral Impairment in Advanced Age

Bernard Weiss, 
  • First Published: 27 December 2010
Review Article
Open Access

Lipid Rafts: Linking Alzheimer′s Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes

Jo V. Rushworth,  Nigel M. Hooper, 
  • First Published: 27 December 2010
Review Article
Open Access

Iron and Mechanisms of Neurotoxicity

Gabriela A. Salvador,  Romina M. Uranga,  Norma M. Giusto, 
  • First Published: 27 December 2010
Research Article
Open Access

New Proteins Found Interacting with Brain Metallothionein-3 Are Linked to Secretion

Issam El Ghazi,  Bruce L. Martin,  Ian M. Armitage, 
  • First Published: 27 December 2010
Research Article
Open Access

Ceruloplasmin/Transferrin Ratio Changes in Alzheimer′s Disease

Rosanna Squitti,  Carlo Salustri,  Mariacristina Siotto,  Mariacarla Ventriglia,  Fabrizio Vernieri,  Domenico Lupoi,  Emanuele Cassetta,  Paolo M. Rossini, 
  • First Published: 27 December 2010
Research Article
Open Access

Ceramide and Related-Sphingolipid Levels Are Not Altered in Disease-Associated Brain Regions of APPSL and APPSL/PS1M146L Mouse Models of Alzheimer′s Disease: Relationship with the Lack of Neurodegeneration?

Laurence Barrier,  Bernard Fauconneau,  Anastasia Noël,  Sabrina Ingrand, 
  • First Published: 27 December 2010
Research Article
Open Access

Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer′s Disease Brain

Elin S. Blom,  Yijing Wang,  Lena Skoglund,  Anita C. Hansson,  Massimo Ubaldi,  Anbarasu Lourdusamy,  Wolfgang H. Sommer,  Matthew Mielke,  Bradley T. Hyman,  Markus Heilig,  Lars Lannfelt,  Lars N. G. Nilsson,  Martin Ingelsson, 
  • First Published: 22 December 2010
Review Article
Open Access

Insight into Glutamate Excitotoxicity from Synaptic Zinc Homeostasis

Atsushi Takeda, 
  • First Published: 20 December 2010
Review Article
Open Access

Biomarkers of Alzheimer′s Disease: From Central Nervous System to Periphery?

Enrico Mossello,  Elena Ballini,  Anna Maria Mello,  Francesca Tarantini,  David Simoni,  Samuele Baldasseroni,  Niccolò Marchionni, 
  • First Published: 20 December 2010
Review Article
Open Access

Mechanisms of Amyloid-Beta Peptide Uptake by Neurons: The Role of Lipid Rafts and Lipid Raft-Associated Proteins

Aaron Y. Lai,  JoAnne McLaurin, 
  • First Published: 20 December 2010
Review Article
Open Access

The Role of Zinc in Alzheimer′s Disease

Nicole T. Watt,  Isobel J. Whitehouse,  Nigel M. Hooper, 
  • First Published: 20 December 2010
Research Article
Open Access

An Intron 7 Polymorphism in APP Affects the Age of Onset of Dementia in Down Syndrome

Emma L. Jones,  Clive G. Ballard,  Vee P. Prasher,  Matthew Arno,  Stephen Tyrer,  Brian Moore,  Maria Luisa Hanney, 
  • First Published: 20 December 2010
Research Article
Open Access

E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity

Takayuki Suzuki,  Kazuma Murakami,  Naotaka Izuo,  Toshiaki Kume,  Akinori Akaike,  Tetsu Nagata,  Tomoyuki Nishizaki,  Takami Tomiyama,  Hiroshi Takuma,  Hiroshi Mori,  Kazuhiro Irie, 
  • First Published: 19 December 2010
Review Article
Open Access

Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer′s Disease

Joseph J. Braymer,  Alaina S. DeToma,  Jung-Suk Choi,  Kristin S. Ko,  Mi Hee Lim, 
  • First Published: 08 December 2010
Review Article
Open Access

Melatonin and Its Agonist Ramelteon in Alzheimer′s Disease: Possible Therapeutic Value

Venkatramanujam Srinivasan,  Charanjit Kaur,  Seithikurippu Pandi-Perumal,  Gregory M. Brown,  Daniel P. Cardinali, 
  • First Published: 08 December 2010
Review Article
Open Access

Hypothesis: Soluble Aβ Oligomers in Association with Redox-Active Metal Ions Are the Optimal Generators of Reactive Oxygen Species in Alzheimer′s Disease

Brian J. Tabner,  Jennifer Mayes,  David Allsop, 
  • First Published: 14 November 2010
Research Article
Open Access

Early Detection of Brain Pathology Suggestive of Early AD Using Objective Evaluation of FDG-PET Scans

James C. Patterson II,  David L. Lilien,  Amol Takalkar,  James B. Pinkston, 
  • First Published: 20 September 2010
Research Article
Open Access

AICD Overexpression in Neuro 2A Cells Regulates Expression of PTCH1 and TRPC5

Mithu Raychaudhuri,  Debashis Mukhopadhyay, 
  • First Published: 15 August 2010