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    2021
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Research Article
Open Access

MicroRNA-137-3p Improves Nonalcoholic Fatty Liver Disease through Activating AMPKα

Yuanjie Yu,  Chunping He,  Shiyun Tan,  Mengjun Huang,  Yitian Guo,  Ming Li,  Qian Zhang, 
  • First Published: 29 December 2021
Corrigendum
Open Access

Corrigendum to “miR-486 Promotes the Invasion and Cell Cycle Progression of Ovarian Cancer Cells by Targeting CADM1”

Hao Wang,  Chenyang Li,  Yunxia Wang,  Nan Li,  Yanli Qin,  Yesheng Wang, 
  • First Published: 24 December 2021

Research Article
Open Access

Downregulation of TET1 Promotes Glioma Cell Proliferation and Invasion by Targeting Wnt/β-Catenin Pathway

Jianwen Ji,  Qiuxiang You,  Jidong Zhang,  Yutao Wang,  Jing Cheng,  Xiangyun Huang,  Yundong Zhang, 
  • First Published: 09 December 2021
Research Article
Open Access

Anlotinib Suppresses Oral Squamous Cell Carcinoma Growth and Metastasis by Targeting the RAS Protein to Inhibit the PI3K/Akt Signalling Pathway

Yunfei Lu,  Jing Lin,  Meng Duan,  Ying Rui,  Hao Zheng,  Liting Zhu,  Xuanyu Zhu,  Jingchen Wei, 
  • First Published: 08 December 2021
Research Article
Open Access

MicroRNA-21-5p Reduces Hypoxia/Reoxygenation-Induced Neuronal Cell Damage through Negative Regulation of CPEB3

Bin Wang,  Ping Yu,  Wei Lin,  Zhaohui Zhai, 
  • First Published: 02 December 2021
Research Article
Open Access

GRHL3 Promotes Tumor Growth and Metastasis via the MEK Pathway in Colorectal Cancer

Lin Tan,  Weiming Qu,  Dajun Wu,  Minji Liu,  Qian Wang,  Qiongjia Ai,  Hongsai Hu,  Min Chen,  Weishun Chen,  Hongbing Zhou, 
  • First Published: 30 November 2021
Research Article
Open Access

Clinical Value and Potential Mechanism of miRNA-33a-5p in Lung Squamous Cell Carcinoma

Xiang-Ming Wang,  Shang-Wei Chen,  Gang Chen,  Hua-Fu Zhou,  Ting-Qing Gan,  Jing-Jing Zeng,  Zu-Yun Li, 
  • First Published: 29 November 2021
Review Article
Open Access

Antitumoral and Anti-inflammatory Roles of Somatostatin and Its Analogs in Hepatocellular Carcinoma

Argyrios Periferakis,  Georgios Tsigas,  Aristodemos-Theodoros Periferakis,  Ioana Anca Badarau,  Andreea-Elena Scheau,  Mircea Tampa,  Simona Roxana Georgescu,  Andreea Cristiana Didilescu,  Cristian Scheau,  Constantin Caruntu, 
  • First Published: 27 November 2021
Research Article
Open Access

Downregulation of lncRNA ANRIL Inhibits Osteogenic Differentiation of Periodontal Ligament Cells via Sponging miR-7 through NF-κB Pathway

Xinwei Liu,  Yue Zhou, 
  • First Published: 24 November 2021
Research Article
Open Access

Mechanism of Chronic Stress-Induced Glutamatergic Neuronal Damage in the Basolateral Amygdaloid Nucleus

Songjun Wang,  Xia Liu,  Weibo Shi,  Qian Qi,  Guozhong Zhang,  Yingmin Li,  Bin Cong,  Min Zuo, 
  • First Published: 23 November 2021
Research Article
Open Access

Establishment and Mechanism Study of a Primary Ovarian Insufficiency Mouse Model Using Lipopolysaccharide

Si-Ji Lv,  Shu-Hui Hou,  Lei Gan,  Jing Sun, 
  • First Published: 16 November 2021
Research Article
Open Access

Nuclear Morphological Characteristics in Breast Cancer: Correlation with Hormone Receptor and Human Epidermal Growth Factor Receptor 2

Jiayu Li,  Yehan Zhou,  Yunzhu Li,  Yang Liu, 
  • First Published: 12 November 2021
Review Article
Open Access

Mitochondrial Mechanisms of Apoptosis and Necroptosis in Liver Diseases

Qingfei Chu,  Xinyu Gu,  Qiuxian Zheng,  Jing Wang,  Haihong Zhu, 
  • First Published: 11 November 2021
Research Article
Open Access

Hypoxia Enhances Activity and Malignant Behaviors of Colorectal Cancer Cells through the STAT3/MicroRNA-19a/PTEN/PI3K/AKT Axis

Yingchun Tang,  Xiahui Weng,  Chang Liu,  Xing Li,  Chao Chen, 
  • First Published: 09 November 2021
Research Article
Open Access

Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway

Haini Wang,  Junli Zuo, 
  • First Published: 06 November 2021
Review Article
Open Access

The Pivotal Immunomodulatory and Anti-Inflammatory Effect of Histone-Lysine N-Methyltransferase in the Glioma Microenvironment: Its Biomarker and Therapy Potentials

Seidu A. Richard,  Kuugbee D. Eugene, 
  • First Published: 27 October 2021
Research Article
Open Access

Expression and Significance of AQP3 in Cutaneous Lesions

Dongfeng Niu,  Yanhua Bai,  Qian Yao,  Wei Hou,  Lixin Zhou,  Xiaozheng Huang,  Chen Zhao, 
  • First Published: 26 October 2021
Research Article
Open Access

FAT1 and PTPN14 Regulate the Malignant Progression and Chemotherapy Resistance of Esophageal Cancer through the Hippo Signaling Pathway

Yingzhi Lu,  Zhenxin Wang,  Ling Zhou,  Zhaoming Ma,  Jianguo Zhang,  Yan Wu,  Yan Shao,  Yunyun Yang, 
  • First Published: 19 October 2021
Research Article
Open Access

Assessment of Immune Cell Populations in Tumor Tissue and Peripheral Blood Samples from Head and Neck Squamous Cell Carcinoma Patients

Ana Caruntu,  Liliana Moraru,  Mihaela Surcel,  Adriana Munteanu,  Cristiana Tanase,  Carolina Constantin,  Sabina Zurac,  Constantin Caruntu,  Monica Neagu, 
  • First Published: 15 October 2021
Research Article
Open Access

Effects of Nanosecond Pulsed Electric Fields in Cell Vitality, Apoptosis, and Proliferation of TPC-1 Cells

Zhenguo Liu,  Yawen Zou,  Ying Sun,  Xiaolong Chen,  Xinhua Chen,  Zhigang Ren, 
  • First Published: 13 October 2021
Research Article
Open Access

circ-SIRT1 Promotes Colorectal Cancer Proliferation and EMT by Recruiting and Binding to eIF4A3

Xiangjie Wang,  Shuang Liu,  Bin Xu,  Yabin Liu,  Peng Kong,  Changlin Li,  Binghui Li, 
  • First Published: 08 October 2021
Research Article
Open Access

TFE3 Regulates the Function of the Autophagy-Lysosome Pathway to Drive the Invasion and Metastasis of Papillary Thyroid Carcinoma

Hongsheng Lu,  Chumeng Zhu,  Yanyun Ruan,  Lilong Fan,  Kena Wei,  Zhaohui Yang,  Qi Chen, 
  • First Published: 07 October 2021
Review Article
Open Access

Long Noncoding RNAs Regulate the Radioresistance of Breast Cancer

Zhifeng Li,  Fujin Wang,  Yinxing Zhu,  Ting Guo,  Mei Lin, 
  • First Published: 21 September 2021
Research Article
Open Access

Curcumin Alleviates Oxygen-Glucose-Deprivation/Reperfusion-Induced Oxidative Damage by Regulating miR-1287-5p/LONP2 Axis in SH-SY5Y Cells

Teng Zhang,  Xiaomin Chen,  Yueqing Qu,  Yanbing Ding, 
  • First Published: 20 September 2021
Research Article
Open Access

Endoplasmic Reticulum Stress Is Associated with the Mesencephalic Dopaminergic Neuron Injury in Stressed Rats

Shiba Niu,  Weibo Shi,  Yingmin Li,  Shanyong Yi,  Yang Li,  Xia Liu,  Bin Cong,  Guanglong He, 
  • First Published: 08 September 2021
Review Article
Open Access

The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy?

Sonja S. Mojsilovic,  Slavko Mojsilovic,  Victor H. Villar,  Juan F. Santibanez, 
  • First Published: 24 August 2021
Research Article
Open Access

A Novel 8-Gene Prognostic Signature for Survival Prediction of Uveal Melanoma

Zhongjun Tang,  Kebo Cai, 
  • First Published: 16 August 2021
Research Article
Open Access

hucMSC Conditioned Medium Ameliorate Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Oxidative Stress and Inflammation via Nrf2/NF-κB Signaling Pathway

Yue Tang,  Fengxia Ding,  Chun Wu,  Bo Liu, 
  • First Published: 14 August 2021
Research Article
Open Access

Molecular, Cytogenetic, and Hematological Analysis of Chronic Myeloid Leukemia Patients and Discovery of Two Novel Translocations

Muhammad Asif,  Abrar Hussain,  Abdul Wali,  Nazeer Ahmed,  Irfan Ali,  Zafar Iqbal,  Muhammad Amir,  Muhammad Shafiq,  Mahmood Rasool, 
  • First Published: 13 August 2021
Research Article
Open Access

miR-486 Promotes the Invasion and Cell Cycle Progression of Ovarian Cancer Cells by Targeting CADM1

Chenyang Li,  Yue Wang,  Hao Wang,  Bowen Wang,  Yunxia Wang,  Nan Li,  Yanli Qin,  Yesheng Wang, 
  • First Published: 05 August 2021

Research Article
Open Access

Histone Deacetylation Regulated by KDM1A to Suppress DACT1 in Proliferation and Migration of Cervical Cancer

Lingjuan Zeng,  Chunyan Chen,  Chanjiao Yao, 
  • First Published: 26 July 2021
Review Article
Open Access

Extracellular Vesicles in the Cornea: Insights from Other Tissues

Tina B. McKay,  Vincent Yeung,  Audrey E. K. Hutcheon,  Xiaoqing Guo,  James D. Zieske,  Joseph B. Ciolino, 
  • First Published: 23 July 2021
Research Article
Open Access

The Synergistic Effect of TRPV1 on Oxidative Stress-Induced Autophagy and Apoptosis in Microglia

Tingting Huang,  Yao Lin,  Qiongyi Pang,  Weimin Shen,  Xiang Chen,  Fengxia Tu, 
  • First Published: 15 July 2021
Research Article
Open Access

Evaluation of the Prognostic Value of Solute Carrier Family 34 Member 2 “SLC34A2” in Papillary Thyroid Carcinoma: An Immunohistochemical Study

Sarah Adel Hakim,  Rasha Mohamed Abd El Atti,  Reham Mohamed Faheim,  Hoda Hassan Abou Gabal, 
  • First Published: 15 July 2021
Research Article
Open Access

miR-142-3p Modulates Cell Invasion and Migration via PKM2-Mediated Aerobic Glycolysis in Colorectal Cancer

JunYu Ren,  Wenliang Li,  Guoqing Pan,  Fengchang Huang,  Jun Yang,  Hongbin Zhang,  Ruize Zhou,  Ning Xu, 
  • First Published: 14 July 2021
Research Article
Open Access

Pannexin1: Role as a Sensor to Injury Is Attenuated in Pretype 2 Corneal Diabetic Epithelium

Garrett Rhodes,  Kristen L. Segars,  Yoonjoo K. Lee,  Audrey E. K. Hutcheon,  Celeste B. Rich,  Vickery Trinkaus-Randall, 
  • First Published: 14 July 2021
Research Article
Open Access

LINC00665 Facilitates the Malignant Processes of Osteosarcoma by Increasing the RAP1B Expression via Sponging miR-708 and miR-142-5p

Limin Wang,  Xinghua Song,  Lijun Yu,  Bing Liu,  Jinfeng Ma,  Weihua Yang, 
  • First Published: 08 July 2021
Research Article
Open Access

Comprehensive Analysis of Competing Endogenous RNA Network Focusing on Long Noncoding RNA Involved in Cirrhotic Hepatocellular Carcinoma

Yuli Zhang,  Dinggui Chen,  Miaomiao Yang,  Xianfeng Qian,  Chunmei Long,  Zhongwei Zheng, 
  • First Published: 23 June 2021
Research Article
Open Access

An In Vitro-In Vivo Evaluation of the Antiproliferative and Antiangiogenic Effect of Flavone Apigenin against SK-MEL-24 Human Melanoma Cell Line

Alexandra Ghiƫu,  Ioana Zinuca Pavel,  Stefana Avram,  Brigitta Kis,  Daliana Minda,  Cristina Adriana Dehelean,  Valentina Buda,  Roxana Folescu,  Corina Danciu, 
  • First Published: 22 June 2021
Research Article
Open Access

Activation of MEK1/2/Nrf-2 Signaling Pathway by Epstein-Barr Virus-Latent Membrane Protein 1 Enhances Autophagy and Cisplatin Resistance in T-Cell Lymphoma

Xintao Jia,  Qiuyu He,  Mei Zeng,  Yuhua Chen,  Yan Liu, 
  • First Published: 19 June 2021
Research Article
Open Access

Identification of a Seven-lncRNA-mRNA Signature for Recurrence and Prognostic Prediction in Relapsed Acute Lymphoblastic Leukemia Based on WGCNA and LASSO Analyses

Haiyan Qi,  Long Chi,  Xiaogang Wang,  Xing Jin,  Wensong Wang,  Jianping Lan, 
  • First Published: 09 June 2021
Research Article
Open Access

Comparison of Ultrasound-Guided Fine-Needle Cytology Quality in Thyroid Nodules with 22-, 23-, and 25-Gauge Needles

YiJie Dong,  LiLi Gao,  Yang Sui,  MinJing Mao,  WeiWei Zhan,  JianQiao Zhou, 
  • First Published: 08 June 2021
Review Article
Open Access

Actin-Binding Proteins as Potential Biomarkers for Chronic Inflammation-Induced Cancer Diagnosis and Therapy

Yu-Gui Zhang,  Jiang-Tao Niu,  Hong-Wei Wu,  Xin-Lei Si,  Shu-Juan Zhang,  Dong-Hui Li,  Tian-Tian Bian,  Yue-Feng Li,  Xing-Ke Yan, 
  • First Published: 07 June 2021
Research Article
Open Access

Cellular Contractility Profiles of Human Diabetic Corneal Stromal Cells

Thi N. Lam,  Sarah E. Nicholas,  Alexander Choi,  Jian-Xing Ma,  Dimitrios Karamichos, 
  • First Published: 07 June 2021
Research Article
Open Access

Interleukin 10 Plays an Important Role in Neonatal Rats with Hypoxic-Ischemia Associated with B-Cell Lymphoma 2 and Endoplasmic Reticulum Protein 29

Xue Bai,  Liu-Lin Xiong,  Chang-Le Fang,  Hao-Li Zhou,  Lu-Lu Xue,  Yue Hu,  Qing-Jie Xia,  Jia Liu,  Jun-Yan Zhang,  Ting-Hua Wang,  Si-Jin Yang, 
  • First Published: 02 June 2021
Research Article
Open Access

N-trans-Feruloyloctopamine Wakes Up BBC3, DDIT3, CDKN1A, and NOXA Signals to Accelerate HCC Cell Apoptosis

Bin Ma,  Jing Li,  Wen-Ke Yang,  Mei-Gui Zhang,  Xiao-Dong Xie,  Zhong-Tian Bai, 
  • First Published: 24 May 2021
Research Article
Open Access

Clinicopathological Significance of FOXO4 Expression and Correlation with Prx1 in Head and Neck Squamous Cell Carcinoma

Yunping Lu,  Yajun Shen,  Lingyu Li,  Min Zhang,  Min Wang,  Lihua Ge,  Jing Yang,  Xiaofei Tang, 
  • First Published: 18 May 2021
Research Article
Open Access

MicroRNA-342 Promotes the Malignant-Like Phenotype of Endometrial Stromal Cells via Regulation of Annexin A2

Dan Sun,  Yiting Wang,  Li Wang,  Xin Guo, 
  • First Published: 17 May 2021
Research Article
Open Access

Downregulation of HBx Restrains Proliferation, Migration, and Invasion of HepG2 Cells

Chaoqun Huang,  Wei Liu,  Xiaochuan Zhao,  Libin Zhao,  Fuxiang Wang, 
  • First Published: 15 May 2021
Research Article
Open Access

GTSE1 Facilitates the Malignant Phenotype of Lung Cancer Cells via Activating AKT/mTOR Signaling

Fan Zhang,  Jingfei Meng,  Hong Jiang,  Xing Feng,  Dongshan Wei,  Wen Meng, 
  • First Published: 03 May 2021
Research Article
Open Access

MRC2 Promotes Proliferation and Inhibits Apoptosis of Diabetic Nephropathy

Lanlan Li,  Xin Chen,  Henglu Zhang,  Min Wang,  Weiping Lu, 
  • First Published: 29 April 2021
Research Article
Open Access

Ultrasound-Targeted Microbubble Destruction Enhances Inhibitory Effect of Apatinib on Angiogenesis in Triple Negative Breast Carcinoma Xenografts

Dengke Hong,  Jiajia Yang,  Jingjing Guo,  Yu Zhang,  Zhikui Chen, 
  • First Published: 19 April 2021
Research Article
Open Access

MicroRNA-520a Suppresses Pathogenesis and Progression of Non-Small-Cell Lung Cancer through Targeting the RRM2/Wnt Axis

Yi Xie,  Congyu Xue,  Shuai Guo,  Lei Yang, 
  • First Published: 31 March 2021
Research Article
Open Access

Identification of a 5-Gene-Based Scoring System by WGCNA and LASSO to Predict Prognosis for Rectal Cancer Patients

He Huang,  Shilei Xu,  Aidong Chen,  Fen Li,  Jiezhong Wu,  Xusheng Tu,  Kunpeng Hu, 
  • First Published: 24 March 2021
Research Article
Open Access

MMP-9 Knockdown Inhibits Oral Squamous Cell Carcinoma Lymph Node Metastasis in the Nude Mouse Tongue-Xenografted Model through the RhoC/Src Pathway

Panpan Yin,  Ying Su,  Suhong Chen,  Jinlin Wen,  Feng Gao,  Yanlin Wu,  Xinyan Zhang, 
  • First Published: 20 March 2021
Research Article
Open Access

Hsa-miR-105-1 Regulates Cisplatin-Resistance in Ovarian Carcinoma Cells by Targeting ANXA9

Xinxin Kou,  Hui Ding,  Lei Li,  Hongtu Chao, 
  • First Published: 24 February 2021
Research Article
Open Access

Comparison of the Fatty Acid Metabolism Pathway in Pan-Renal Cell Carcinoma: Evidence from Bioinformatics

Ping Wu,  Yingkun Xu,  Jiayi Li,  Xiaowei Li,  Peizhi Zhang,  Ningke Ruan,  Cong Zhang,  Panpan Sun,  Qifei Wang,  Guangzhen Wu, 
  • First Published: 23 February 2021
Research Article
Open Access

Ferrotoxicity and Its Amelioration by Calcitriol in Cultured Renal Cells

Chandrashekar Annamalai,  Rohit Seth,  Pragasam Viswanathan, 
  • First Published: 23 February 2021
Research Article
Open Access

IMP3 Immunohistochemical Expression in Inverted Papilloma and Inverted Papilloma-Associated Sinonasal Squamous Cell Carcinoma

Sarah A. Hakim,  Nermine M. Abd Raboh,  Lobna S. Shash, 
  • First Published: 17 February 2021
Research Article
Open Access

Endoplasmic Reticulum Stress Is Involved in Glucocorticoid-Induced Apoptosis in PC12 Cells

Shanyong Yi,  Weibo Shi,  Min Zuo,  Songjun Wang,  Rufei Ma,  Haitao Bi,  Bin Cong,  Yingmin Li, 
  • First Published: 12 February 2021
Research Article
Open Access

Inhibitory Effect of the LY2109761 on the Development of Human Keloid Fibroblasts

Xiuxia Wang,  Chuan Gu,  Feng Shang,  Rui Jin,  Jia Zhou,  Zhen Gao, 
  • First Published: 10 February 2021
Research Article
Open Access

Protective Effects of Astragalus Polysaccharide on Sepsis-Induced Acute Kidney Injury

Jie Sun,  Shanzhai Wei,  Yilai Zhang,  Jia Li, 
  • First Published: 27 January 2021
Research Article
Open Access

Exploration of the Immune-Related Signatures and Immune Infiltration Analysis in Melanoma

Ai-lan Li,  Yong-mei Zhu,  Lai-qiang Gao,  Shu-yue Wei,  Ming-tao Wang,  Qiang Ma,  You-you Zheng,  Jian-hua Li,  Qing-feng Wang, 
  • First Published: 16 January 2021