Currently, the recognition that dupilumab may be beneficial for the management of alopecia areata in severe atopic dermatitis patient is seemingly spreading. At the same time, worsening of alopecia areata during dupilumab treatment has also been noted as presented in this report. This study alert physicians that use if dupilumab in expectation of alopecia areata improvement in alopecia areata concomitant with atopic dermatitis cases can lead to unfortunate consequence in some patients.

Persistent VZV infection after mRNA COVID-19 vaccination and associated spike protein in the lesion

We report a case of 70-year-old woman with rectal malignant melanoma that recurred in the pelvic lymph node one year after surgery. Nivolumab was initiated and she achieved complete response after one year, but she discontinued nivolumab at her instance. At a follow-up 21 months after the discontinuation of nivolumab, a pelvic lymph node metastasis recurrence and a lung metastasis discovered. Nivolumab rechallenge was initiated, but it was not successful.

A. Facial swelling during a hereditary angioedema (HAE) attack. B. Computed tomography image of the abdomen with intestinal edema during an HAE attack. C. Histogram of the frequency of monthly HAE attacks during self-administration of icatibant. The asterisk indicates when HAE attacks were treated by on-demand injection of plasma-derived C1 inhibitor at the emergency room.

Cerebellar metastasis from malignant melanoma of the inner canthus was resected. The patient was subsequently treated with ipilimumab and has remained disease-free 6 years, however, developed sarcoidosis.

A 50-year-old Japanese woman with limited cutaneous-type SSc presented with severe gangrene in the fingertips of the hands and hypertension, tested positive for anti-PL-12 antibodies. She was diagnosed with acute heart failure owing to scleroderma renal crisis and pulmonary arterial hypertension. Therapeutic agents for pulmonary arterial hypertension were also effective for the digital gangrene.

An immunohistochemical study of human vitiligo case was performed. The excimer laser irradiation may induce the differentiation of melanoblasts and melanocytes from bulge stem cell.