:

A systematic review and meta-analysis of 14 randomized controlled trials showed that dexmedetomidine is associated with a reduced risk of postoperative cognitive dysfunction in elderly patients receiving surgeries with general anesthesia, and the results were mainly obtained in studies with postoperative cognitive dysfunction diagnosed with MMSE. Based on these findings, Dex may be considered as a preventative measure for postoperative cognitive dysfunction in elderly patients.

-

:This study focuses on the function of EMX1 in SCG and its related biological molecules. We first identified reduced EMX1 in SCG tissues and the isolated cells, especially in the high-grade cancers. Upregulation of EMX1 suppressed, whereas downregulation of EMX1 promoted malignant development of SCG cells in vitro and in vivo. EMX1 suppressed the transcription of WASF2 to inactivate the Wnt/β-catenin pathway. The tumor-suppressive effects of EMX1 were blocked upon WASF2 restoration, and the SCG cell growth and metastasis triggered by WASF2 was suppressed by artificial Wnt/β-catenin inhibition. Taken together, we opine that EMX1 suppresses WASF2 transcription and inactivates the Wnt/β-catenin axis pathway to suppress SCG development.

In the present study, EEG characteristics during anticipated and acute nausea were investigated in an experimental nausea paradigm in 45 men and 45 women. Compared with no treatment, the placebo intervention reduced the expected intensity of nausea inall participants, which was associated with increased ACC and PFC activity. Furthermore, the placebo intervention alleviated acute nausea similarly in both sexes, whereas cortical changes differed: Women showed lower activation in the parietal, frontal, and temporal lobes, while men displayed increased activation in the limbic and insular lobes.

-

Flunarizine combined with duloxetine in the treatment of chronic migraine with depression and anxiety disorder can effectively improve neuroelectrophysiological indexes, reduce inflammation, and reduce depression and anxiety.

-

This study planned and conducted to investigate the relationship emotional intelligence and parental stress management during Covid-19 pandemic. Taking into account the role of emotional intelligence parameters in stress management, this study aimed to show how a family can stand on its own feet and overcome the crisis safely.

Maheen Adamson, Srija Seenivasan, Caglar Uyulan, Turker Erguzel, Onder Cerezci, Reza Kazemi, Siddhi Shah, Angela Phillips, Nevzat Tarhan. Sex differences in rTMS treatment response: A deep learning-based EEG investigation. We developed a novel pipeline based on convolutional LSTM-based deep learning to classify 25 female and 25 male patients based on their rTMS treatment response. Five different classification models were generated: pre-/post-rTMS female (model 1), pre-/post-rTMS male (model 2), pre-rTMS female responder /nonresponder (model 3), pre-rTMS male responder/nonresponder (model 4), and pre-rTMS responder/nonresponder (model 5), achieving respectively 93.3%, 98%, 95.2%, 99.2%, and 96.6% overall test accuracy, and indicating the potential of our approach to be used as a response predictor especially regarding sex-specific antidepressant effects of rTMS in MDD patients. These results indicate the potential of our approach to be used as a response predictor of sex-specific antidepressant effects of rTMS in MDD patients and to help guide clinicians to administer more personalized interventions.

Repetitive transcranial magnetic stimulation was effective in improving the FOG-Q scores, 10 m walking time, TUG scores, MOCA, and FAB.Repetitive transcranial magnetic stimulation showed a beneficial effect on FOG and cognitive dysfunction in parkinsonism.

-

Graphical Abstract.

-

-

This review aims to scientifically resolve the correlation between eye movement dysfunction in mTBI with advanced neuroimaging. Included are the neuroanatomical basis of eye movement control, novel MRI correlations to eye tracking measures in mTBI patients, and areas requiring future research.

Our study demonstrated that GNRI scores at admission were associated with the risk of SAP, and lower GNRI score indicated a higher risk of SAP. Besides, there existed a non-linear relationship between GNRI and the risk of SAP. GNRI showed predictive value for SAP, which could be useful for early SAP intervention and therapy.

Inhibition of PKR may significantly ameliorate SAH-induced EBI by regulating iron death.

The figure was drawn and analyzed by Adekunbi Oluyemisi, Olivier Uwishema, Ashraf Mahmoud, and Inês F. Silva Correia.