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There were varied degrees of change from behavior to molecular levels in the three models of depressive mice throughout the length of the modeling time. This includes an evaluation of the time period to be investigated when testing new antidepressants.

The results indicated that CYP24A1 rs1570669 was significantly association with stroke risk. Stratification analysis found that rs6068816 could enhance the stroke risk by 1.64 times at age >64 years, and rs2762934 had an increased stroke susceptibility in age ≤64 years. We observed that CYP24A1 rs2296241was associated with the increased stroke risk in males than in females.

This study aimed to validate the Italian version of M-BACK questionnaire (M-BACK-IT) and to determine the test–retest reliability. Thirty mental health professionals (4 psychiatrists, 9 psychologists, 12 nurses, and 5 exercise specialists) completed the M-BACK-IT, intraclass correlation coefficients (ICC) were calculated for the total score, and each of the four M-BACK domains, ICCs, ranged from 0.58 to 0.94.

In this study, a systems biology approach focusing on the function correlation and interaction of the candidate genes related to major depressive disorder was adopted to explore the molecular mechanisms underlying the disease. Major pathways and the cross talks among them were detected, and novel genes potentially related to the disease were also identified.

In our current study, we conducted an observational study to investigate the association of the retinal sublayer thickness on OCT with focal markers of brain tissue on MRI in participants with WMH using the Fazekas scale. Retinal degeneration in the RNFL and GCIP was independently associated with focal lesions in the white matter of the brain and deteriorates with the severity of the lesions. We suggest that imaging and measurement of the retinal sublayers using the OCT may provide evidence on neurodegeneration in WMH.

This study adapted a scale to assess SE and SS in promoting physical activity in Spanish people with SMDs, as well as provide preliminary evidence of its validity.

It is the first to investigate the effects of IH exposure on spatial memory, cognition, and anxiety-related behavior in the APP/PS1 mouse model of AD. IH improves cognition and reduces anxiety in a murine model of AD.

The rapidity of cortisol elimination after the stress event (a heel stick blood draw) was important in determining infant early temperament. The 5-HTTLPR short allele and the MAOA low expressing allele predisposed their carriers to negative emotions proneness and lower regulatory capacity, the Met allele of COMT predisposed their carriers to more extraverted and regulated behavior.

This paper proposed a method based on kernel PCA and Riemann manifold to characterize patients with OCD from healthy controls, whose performance reaches 90%. Furthermore, by feature reconstruction, our algorithm could generate decisive features from the classification model. Results demonstrate the possible affect of cerebellum in the etiology of OCD.

One-third of patients with ischaemic stroke before 70 years of age showed increased muscle tone at 7-year follow-up. Half of them also had classical spasticity, and almost every tenth had one or more contractures. Increased muscle tone was predicted by age, arm paresis, aphasia, and facial palsy at index stroke.

We investigated the associations between personality and resting-state functional MRI data from 365 individuals across the adult lifespan (20–80 years). We found that openness was positively associated with connectivity in the default mode network, neuroticism was negatively associated with both the ventral and dorsal attention networks, and agreeableness was negatively associated with the dorsal attention network. In addition, age moderated the association between conscientiousness and the frontoparietal network, indicating that this association becomes stronger in older age.

We provide novel evidence in support of findings in rodent models suggesting that in utero exposure to maternal obesity differentially impacts the hippocampus of boys compared to girls during childhood. This is the first study in humans to show changes to the hippocampus in association with in utero exposure to maternal obesity.

Metabolomics was used to reveal the gain a metabolic perturbation of TBI in rats. Acute TBI was susceptible to metabolic disorders, and joint metabolite-protein network analysis provides a favorable prediction to TBI pathogenesis mechanism in the brain.

To describe schizophrenia from childhood to adulthood is complex and patients with early-onset schizophrenia (EOS) remain undiagnosed or misclassified, especially the subgroup with very early-onset schizophrenia (VEOS). In patients with VEOS, the DUP which exceeds 8 years, almost eight times higher than in patients with AOS, objective the problem of early diagnosis and the need to develop diagnostic programs and management cares.

The adaptive spatial span training decreased brain activation in the prefrontal and parietal cortex. The COMT Val158Met polymorphism modulated the left frontal plasticity induced by training.

Acupuncture modulation elicited a bidirectionally regulated effect on default mode network (DMN) in chronic sciatica patients. The changes in subclinical endophenotype of brain FC after acupuncture treatment may provide clues for understanding the mechanism of acupuncture-mediated analgesia in chronic pain.

Here, we used a data-driven approach to investigate how individual differences in distributed intrinsic functional brain connectivity predict emotion regulation tendency. We found a significant neuromarker of dispositional use of suppression, but not reappraisal. These findings help inform how whole-brain networks of functional connectivity characterize how people tend to regulate emotion outside the laboratory.

The effects of intranasal administration of the neuropeptide oxytocin on social cognition and behavior are highly specific. Our findings demonstrate that oxytocin versus placebo administration can promote self-serving lying to a certain degree when given repeated opportunities to lie.

There is a substantial elevation in serum sLOX-1 levels after aSAH. There is an intimate correlation of serum sLOX-1 levels with hemorrhagic severity. There is an independent association of serum sLOX-1 levels with delayed cerebral ischemia.

This newly established behavioral sensitization model for tree shrews will be useful to those studying the neural basis of addiction. Such investigations could lead to the development of pharmacotherapies to treat drug dependence.

This study aimed to find a more sensitive and systematic behavioral evaluation protocol to evaluate the cognitive impairment in rats with heart failure (HF).The cognitive impairment in rats with HF mainly reflected in the long-term and working memory, spatial learning and reversal learning ability.

Spinal cord injuries are devastating, with many complications beyond paralysis and loss of sensory function. A recommended solution is to take advantages of the regenerative mechanism of axolotls and the current knowledge about the pattern-forming glycosaminoglycans for successful spinal cord regeneration and clinical applications.