We found that the incidence rate of poor sleep quality is significantly higher in PSA patients than in non-PSA patients. Poor sleep quality before stroke is independently associated with the development of PSA, even after adjustment for several conventional confounders. These findings suggested poor sleep quality before stroke could provide important predictive information for anxiety after acute ischemic stroke.

We sought biomarkers from resting-state electroencephalography (EEG) data that could be used to accurately distinguish ASD children and typically developmental (TD) children. When we used individualized alpha peak frequency (iAPF) and individualized alpha absolute power (iABP) as features for a linear support vector machine, ASD versus TD classification accuracy was 92.7%, suggesting that our methods have potential to assist in clinical diagnosis.

This study measured the effect of stereotyping threat on inhibition and attention abilities in impoverished and rich people using behavioral and ERP measures. We believe that our study makes a significant contribution to the literature because it is among the first to use behavioral and electrophysiological approaches to explore the underlying neural mechanisms of inhibitory differences to poverty-related stimuli.

A retrospective analysis of 39 patients with bipolar depression treated with a standardized protocol of transcranial magnetic stimulation (TMS) demonstrated a response rate of 77% and a remission rate of 41%. These preliminary data support further exploration of TMS as a possible intervention in this condition for which few treatment options exist.

We compared the effects of a single session and five accelerated sessions of 1 Hz rTMS to the visual cortex on GABA+ and Glx (glutamate and glutamine) neurotransmitter levels. GABA+ and Glx concentrations were unaltered following a single session of rTMS to the visual cortex. However, accelerated rTMS reduced GABA+ for 24 hr, returning to baseline 1-week post-rTMS.

One of the most desired goals of developmental research is to be able to predict childhood behavioral outcomes based on brain biomarkers as early as possible to facilitate in-time intervention. However, this problem is notoriously challenging, partly due to the complex nature of brain function and reportedly weak brain–behavioral relationships. In this study, we derived a simple, training-free prediction scheme to abstract the neonatal whole-brain functional connectivity pattern to three outlier measures (Triple O) and showed that it could identify over forty percent of 4-year IQ performance outliers with a high level of robustness against different reference samples. Results in this study represent a first step in this novel direction of brain outlier-based prediction of later behavioral outcomes.

1. Inhibition the expression of RNF suppressed the cerebral inflammation. 2. Inhibition of RNF6 alleviated traumatic brain injury.

Obesity and major depressive disorder (MDD) independently contribute to memory impairment. This study's aim was to determine how obesity impacts neural activity during a verbal recognition memory task in individuals both with and without MDD. Results indicate that obesity in conjunction with MDD confers a subtle impact on neural functioning.

Either i.p. or i.t. AM1710 reversed CCI-induced mechanical allodynia in CB1R (−/−), (+/−), (+/+) mice similar to sham control threshold levels. The absence of the CB1R following CCI-induced neuropathy revealed greater significant increases in IL-10 immunoreactivity (IR) in the dorsal root ganglia (DRG) and the dorsal horn of the spinal cord in (−/−) and (+/−) mice that was further elevated following i.t. and i.p. AM1710. The absence of CB1R may allow for enhanced tissue/axon damage-associated signaling to the DRG and spinal cord, resulting in endogenous compensatory increases in IL-10 expression.

The aim of the present study was to evaluate serum homocysteine concentration and its relationship with oxidative stress levels in patients with PD, regarding homocysteine as a diagnostic biomarker of heart disease. Our findings support that, patients with PD experience higher levels of oxidative stress, due to impaired serotonin metabolism, which is related to the prognosis of heart disease in these patients.

We use a 7 T MRI scanner along with a combination of advanced acquisition, reconstruction, and postprocessing techniques to derive metabolic distribution in deep brain structures.

Deductive reasoning is supported by a distributed network of regions encompassing frontal/parietal cortices and subcortical structures (e.g., caudate). The results of our conjunction analysis highlight the IFG, insula, and cingulate (the key neural hubs of the cingulo-opercular network) as core locus of deductive reasoning.

BECTS patients have a certain degree of cognitive dysfunction in the early stage of the disease. The functional connections of patients with early BECTS showed unbalanced brain topology, and the brain network pattern was tending to be randomized. This trend of cognitive decline in early BECTS children may be related to the change of FC network patterns.

PHQ-9 score on admission to convalescent rehabilitation ward was an independent significant factor influencing the FIM gain score and the inability to discharge home.

To the best of our knowledge, few studies have focused on the specific relationship between neutrophil-to-lymphocyte ratio (NLR) and the short-term prognosis of patients with mild acute ischemic stroke (AIS) and treated with intravenous thrombolysis (IVT). Our study evaluate whether an increased NLR was predictive of a poor short-term outcome in patients suffering from mild AIS and treated with IVT. A high NLR (≥3.9) was associated with a poor outcome in patients with mild AIS treated with IVT, at both discharge and 3 months after onset.

Childhood adversity leads to experience-dependent brain modification of anatomic connectivity in the medial orbitofrontal cortex. Childhood adversity leads to experience-dependent brain reorganization of functional connectivity within the language network. Interactive effects between childhood trauma and the COMT Val158Met polymorphism suggest that the Met heterozygote contributes to negative effects of childhood trauma on brain connectivity involving motor performance, emotion regulation, executive function, and cognitive control.

A novel missense mutation in KCNAB3 was found in sufferers of a Chinese Han GEFS+ family using whole-exome sequencing. Functional verification showed that KCNAB3 mutation could accelerate the inactivation of potassium channels, thus inhibiting potassium current, improving neuronal excitability, and promoting epileptic convulsion. It is the first report about mutation in KCNAB3 gene relating to GEFS+, and these findings may provide a new insight that mutations in the KCNAB3 gene may be the pathology of GEFS+.

We investigated which variables predict changes after an online reasoning cognitive training program and could show that being female and lower education predicted improvements in grammatical reasoning scores at 6 weeks and 3 months of training. Identifying predictors for nonpharmacological interventions may help to set up a personalized medicine approach in order to prevent cognitive decline in health older adults.

Adolescents with EOP or EOBP had an increased LCCA intima thickness, interpreted as a sign of preclinical atherosclerosis. Global function of the disorders was the strongest determinant of intima thickness.

The purpose of this study was to explore relations among acculturative stress, anxiety, somatization, and resilience in a sample of Latinx immigrants living in the United States. Acculturative stress was positively related to both anxiety and somatization, and the relation between acculturative stress and somatization occurred through anxiety. Resilience moderated the relations between acculturative stress and somatization, and between anxiety and somatization.

Therapeutic principles for persistent postural–perceptual dizziness (PPPD) comprise cognitive–behavioral therapy, vestibular rehabilitation exercises, and serotonergic medication. Follow-up observations of patients subjected to multimodal interdisciplinary therapy reveal an improvement in symptoms in most patients with chronic dizziness.

By proteomic analysis, we identified plasmalemmal voltage-dependent anion channel (pl-VDAC) as one of membrane targets for 15d-PGJ₂. An anti-VDAC antibody suppressed the neurotoxicity of 15d-PGJ₂ partially, but significantly, suggesting that pl-VDAC might contribute to the neurotoxicity of 15d-PGJ₂.

Although the underlying pathophysiological mechanism of poststroke aphasia (PSA) is greatly concerned, it remains unclear. By coordinate-based (ALE) meta-analysis, we found that the activation of the left superior frontal gyrus (SFG) and the parietal postcentral gyrus of PSA presented hypoactivation, while there was hyperactivation in the right cerebellar anterior lobe, fusiform gyrus, superior temporal gyrus (STG), superior parietal lobule (SPL), and subgyral hippocampus. It is worth noting that the changed functional status of area in brain is more involved in right lobe. The future studies on rehabilitation should be given more attention to the right area.

The BD shows greater reduction of white matter integrity in body of the corpus callosum compared to the MDD, and the abnormality correlates with dysfunction in sustained attention.

This study established a novel, longitudinal method which uses machine-learning algorithm to discriminate individuals with normal cognition (NL) from those with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Our method achieves sufficient accuracy to discriminate NL from MCI and AD with minimally invasive scans obtained at only two time points (0 and 6 months).

Through factor analysis, items of the TAQ were grouped into relevant domains, and the uni-dimensionality of each domain was verified using IRT. When the Rasch model, the simplest form of IRT, is used to evaluate the difficulty distribution of items in the same scale, the probability of success for a person that an item is endorsed reflects the degree of the trauma experience and the difficulty of the item; in this case, the exposure level of the participant and the severity of the item.

Knowledge about what causes dystonia is highly incomplete, especially about the impact of non-genetic factors. This cross-sectional survey-based study examined different non-genetic factors in patients with dystonia. Smoking was approximately twice as common in our studied population compared to the general Swedish population.

We studied the lateralization of verbal emotional memory depending on the emotional valence using a sample composed of subjects with medial temporal lobe epilepsy (MTLE) who received an amygdalohippocampectomy and a control group. Patients with MTLE show a deficit in the verbal recall which is exacerbated for information with an affective component. This deficit is more prominent in the case of patients with left unilateral resection (MTLE-left group) since they lose the benefits of the emotional information for the recall.

The objective of this study was to characterize the pathways linking health beliefs to treatment utilization among 5,343 young adults who screened positive for severe depression. Improved depression treatment utilization was significantly associated with higher levels of perceived severity, self-efficacy, and cues-to-action, whereas perceived benefits and perceived barriers were associated with lower depression treatment utilization. Health beliefs are useful to predict the frequency of seeking treatment by individuals for depression.

The white noise is an environmental sound which applied in the psychological status by blocking other distracted sound and facilitating to occur the alpha wave. Psychological anxiety related in the performance of the activities is effected positively by the application of the white noise during the activity. As the elderly with mild dementia has a characteristic affecting easily by the environmental noise and stimulation due to the low level of cognition, their gait is easily affected, increasing the risk of falls.

Current evidence cannot suggest that perioperative use of lidocaine has pharmacological brain neuroprotection after noncardiac surgery. All the included studies were small-scale research, and the total number of participants was small; the results should be interpreted with caution.

Bright light therapy is an effective treatment for reducing depression symptoms among patients with bipolar depression.

We replicate the recently discovered left digit effect in number line estimation. Unlike overall accuracy, the left digit effect is not correlated with math achievement, suggesting a different cognitive source.

The pattern separation ability which distinguishes similar but different stimuli is the kernel of our memory. The novelty and the social significance lies in its evaluation of the associations between the pattern separation ability related to neurogenesis and the volumes of the subfields including the dentate gyrus of the hippocampus in healthy young adults. There were no significant causal associations when adjusted with covariates.

Gene prioritization approaches are useful tools to explore and select candidate genes in transcriptome studies. To identify functional candidate genes associated with these processes in an animal model of inflexible pattern of ethanol intake we applied a guilt-by-association approach using the GUILDify and ToppGene software. Identification of transcription factors among the prioritized genes suggests a crucial role for Irf4 in the pattern of regulation observed between PFC and striatum.

The COVID-19 pandemic put healthcare professionals in challenging situations. This study assessed the impact of working with COVID-19 patients on parameters of mental health of the healthcare workers. Frontline medical staff with close contact with patients with COVID-19 reported significantly higher levels of stress, anxiety, and depression than second-line medical personnel, and they were also found to be twice more likely to develop more severe anxiety symptoms. Measures should be taken to relieve this psychological burden of frontline medical staff.

The CD200-CD200R1 signal pathway is disturbed in acute stroke, and the disequilibrium of CD200-CD200R1 signal pathway regulates the neuron-inflammatory pathways in diversity. High expression of CD200R1 promotes the ischemic brain to release the anti-inflammatory cytokines and mediators to relieve the ischemic injury.

We investigated whether disruption of the inferior longitudinal fasciculus is associated with visual hallucinations in Parkinson's disease (PD) used by diffusion tensor imaging. A multivariable logistic analysis adjusted by MMSE scores showed a significant association between the presence of visual hallucinations and fractional anisotropy and mean diffusivity values of the left inferior longitudinal fasciculus. Our results suggest that disruption of left inferior longitudinal fasciculus integrity is associated with visual hallucinations in patients with PD, independent of cognitive impairment.

We found that resilience, but not depression, was strongly associated with vitamin D levels in 1,908 subjects from the general population. The association with resilience remained stable after adjustment for depressive symptoms. Functional polymorphisms of the vitamin D-binding protein gene (rs4588 and rs7041) were highly associated with vitamin D levels, but neither depression nor resilience.

This is a study focusing on associations between Brain-Derived Neurotrophic Factor (BDNF) single nucleotide polymorphism, plasma Levels, and cognitive impairment in Chinese patients with panic disorder (PD).We found the BDNF Met/Met genotype may be associated with lower BDNF plasma levels and some domains of cognitive impairments in PD patients.

Diagnostic lumbar puncture is commonly complicated by postdural puncture headache (PDPH), and several studies comparing the incidence of PDPH have confirmed a clear benefit of the atraumatic spinal needle. Despite this, neurologists seem to keep using the traumatic needle. This study provides strong support to make a change in practice where traumatic needles are still in regular use.

There are very few services available for people in the early stages of dementia, especially in terms of health promotion. This study explored the effects of a 12-week health promotion intervention for home-dwelling people with early-stage dementia. The findings suggest that a 12-week health promotion course can improve depressive symptoms and self-rated health in people with early-stage dementia. The participants’ cognitive function, P-ADL, and neuropsychiatric symptoms were stable during the 4-month follow-up.

The functional connectivity within the DMN was associated with hypoxemia severity, as revealed by apnea-hypopnea index, oxygen desaturation index, and nadir SaO₂ (%), rather than with degree of sleep disruption, as shown by sleep efficiency and wake after sleep onset.

(a) Children with GTCS exhibited a small-world topology of their functional network; (b) Detected significant decrease of regional topological organization in children with GTCS; (c) Network metrics in bilateral temporal pole of MTG showed negative correlations with the epilepsy duration.

Densin-180, a postsynaptic molecule, in ventral hippocampal neurons is necessary for the contextual fear memory formation during the critical time window at 1~2 hr postlearning. Densin-180 also affect the phosphorylation status of CaMKII both at basal state and after contextual fear learning. This study shows that densin-180 is involved specifically and differentially in contextual fear memory formation and/or retrieval process depending on its septo-temporal location of hippocampus and pattern of learning stimuli.

Inflammatory reaction plays a critical role in the pathogenesis of RBI. Low vitamin D levels are closely associated with various immuno-inflammatory diseases, but the relationship with late delayed RBI remains unknown. Here, we reported that patients with RBI had significantly lower serum levels of 25(OH)D3 than age-, season- and sex-matched control subjects. Furthermore, low levels of 25(OH)D3 were associated with female sex, older age, short latency, and disease disability.

Sex differences in underweight and body mass index in Chinese early de novo patients with Parkinson's disease (PD) have not been investigated before, our study suggests that there are significant sex differences in the prevalence of underweight, body mass index (BMI), and factors associated with underweight and BMI among de novo PD patients; therefore, sex-specific management strategies such as dietary structure, physical activity, and nutritional status interventions may have certain clinical significance for improving life quality and prognosis of patients.

In this original paper, we hypothesized that performance in creativity tests can be predicted based on microstructural integrity of the corticostriatal pathways and basal ganglia based on diffusion MRI.

We aimed to delineate differential effects of stress acting before or after hierarchy formation. In newly established social hierarchies of stress-naïve mice, the subordinate, mice exhibited significantly greater avoidance of novel social targets. Following exposure to chronic social stress, both lowest and highest ranking mice exhibit the susceptible phenotype. However, the largest change in social interaction before and after social stress was observed in the dominant mice.

This study is the first to thoroughly investigate associations between GPx-1 polymorphisms and personality traits. Our results demonstrated that rs1050450 was significantly associated with the disorderliness trait. The rs1800668 polymorphism in GPx-1 affected the personality trait of impulsiveness in healthy Chinese-Han subjects.

The present study provided evidence that increased early SBPV after EVT is related to worse longer-term functional outcome in AIS, but the association is not significant in AIS patients treated with IVT. Furthermore, individualized BP management strategies were essential for AIS patients after EVT or IVT.

The current study reported around 5% of anxiety disorder among adolescent in Bangladesh and it significantly increases the tendencies of adolescent’s suicidal behaviour (ideation, plans and attempts) and alcohol and drug abuse tendencies. Several single and multiple adverse psychosocial and socio-environmental experiences are accelerating the risk.

The efficacy and cognitive effects between MST and bifrontal ECT for treating patients with depressive episodes were compared. Both MST and ECT improved the patients’ depressive symptoms significantly. MST showed similar efficacy to bifrontal ECT for treating depressive episodes and may be an alternative to ECT.

We used a relatively large dataset of EEG time–frequency measures for the Go/NoGo task to develop a machine learning based classifier of successful selection and inhibition trials. This neural network classifier accurately identified individual task conditions at an overall rate of 92%, estimated by fivefold cross-validation. The signatures of the classifier not only replicated the previous main findings of the Neural Hybrid model for selection and inhibition processes in location and time–frequency correlates, but extended these findings with additional signatures not previously isolated.