• Issue

    Journal of Arrhythmia: Volume 41, Issue 4

    August 2025

CLINICAL REVIEW

Open Access

Pulsed-Field Ablation Versus Radiofrequency Ablation for Paroxysmal Atrial Fibrillation: A Systematic Review and Meta-Analysis

  • First Published: 04 August 2025
Pulsed-Field Ablation Versus Radiofrequency Ablation for Paroxysmal Atrial Fibrillation: A Systematic Review and Meta-Analysis

Meta-analysis of 2353 paroxysmal AF patients shows pulsed-field ablation (PFA) reduces total procedure time by 39 min and left-atrial dwell time, increases fluoroscopy time by 11 min, and achieves 1-year AF-free survival and safety rates comparable to radiofrequency ablation. High heterogeneity may reflect operator learning curves and catheter workflows.

ORIGINAL ARTICLE

Open Access

Management of device embolization following left atrial appendage closure: Two cases and a review of the literature

  • First Published: 01 August 2025
Management of device embolization following left atrial appendage closure: Two cases and a review of the literature

Device embolization following left atrial appendage closure occurs in 0.6%–1.5% of cases and represents a rare but serious complication that can be effectively managed through tailored percutaneous retrieval strategies with high procedural success rates when performed by experienced operators.

Open Access

Impact of the Distance From the Cavotricuspid Isthmus to the Right Coronary Artery on First-Pass Conduction Block During Cryoablation for Atrial Flutter

  • First Published: 31 July 2025
Impact of the Distance From the Cavotricuspid Isthmus to the Right Coronary Artery on First-Pass Conduction Block During Cryoablation for Atrial Flutter

A shorter distance from the cavotricuspid isthmus to the right coronary artery reduces the success rate of achieving first-pass conduction block during cryoablation for cavotricuspid isthmus-dependent atrial flutter, likely due to the warming effect of coronary blood flow.

Open Access

Long-Term Follow-Up of Superior Vena Cava–Right Atrium Spontaneous Conduction Block Line Durability Using the White-Line Approach of Extended Early Meets-Late Rate Tools

  • First Published: 31 July 2025
Long-Term Follow-Up of Superior Vena Cava–Right Atrium Spontaneous Conduction Block Line Durability Using the White-Line Approach of Extended Early Meets-Late Rate Tools

Spontaneous superior vena cava (SVC)–right atrium (RA) conduction block lines, visualized as white lines using the extended early meets-late (EEML) tool in the CARTO system, were associated with durable long-term SVC isolation, supporting the efficacy of the white-line approach.

Open Access

Impact of Breathing and Anatomical Constraints on Subxiphoid Epicardial Puncture: Insights From a Japanese Cohort

  • First Published: 30 July 2025
Impact of Breathing and Anatomical Constraints on Subxiphoid Epicardial Puncture: Insights From a Japanese Cohort

This study reveals that respiratory phase and anthropometric parameters significantly impact the xiphoid-to-pericardium distance, with expiration increasing the depth. These findings support the use of preprocedural ultrasound to optimize subxiphoid epicardial access, enhance safety, and inform needle selection based on individual anatomical characteristics.

Open Access

Impact of Ablation Targeting Atrial Drivers and Fragmented Potentials on Long-Standing Persistent Atrial Fibrillation: A Retrospective Study

  • First Published: 29 July 2025
Impact of Ablation Targeting Atrial Drivers and Fragmented Potentials on Long-Standing Persistent Atrial Fibrillation: A Retrospective Study

Targeted ablation of atrial drivers and fragmented potentials showed a trend toward lower atrial fibrillation recurrence and significantly reduced premature atrial contractions, highlighting the bottom region of the left atrium as a promising ablation target in long-standing persistent AF.

Open Access

Trajectories of Lipid Profile Changes and Cardiovascular Outcomes in Elderly Asian Patients With Atrial Fibrillation

  • First Published: 28 July 2025
Trajectories of Lipid Profile Changes and Cardiovascular Outcomes in Elderly Asian Patients With Atrial Fibrillation

Lipid trajectory patterns are linked to cardiovascular outcomes in elderly Asian patients with atrial fibrillation; specifically, stable mid-range total cholesterol and LDL, along with persistently high HDL levels, are associated with improved survival.

Open Access

High-frequency content within the QRS complex can predict ventricular tachyarrhythmias in hypertrophic cardiomyopathy

  • First Published: 28 July 2025
High-frequency content within the QRS complex can predict ventricular tachyarrhythmias in hypertrophic cardiomyopathy

This study first measured frequency power profiles during the QRS complex (QRS) in HCM patients. The high-frequency content (150–250 Hz) hidden in the QRS can predict L-VAs in HCM, even if fragmented or notched QRS is not observed.

Open Access

Clinical and Electrophysiological Characteristics of Patients Developing Macroreentrant Atrial Tachyarrhythmias Following Cardiac Surgery: A Retrospective Cohort Study

  • First Published: 28 July 2025
Clinical and Electrophysiological Characteristics of Patients Developing Macroreentrant Atrial Tachyarrhythmias Following Cardiac Surgery: A Retrospective Cohort Study

In patients with repaired congenital heart disease and macro reentrant atrial tachycardias, a strategy of high-density mapping, using a combination of isochronal late activation mapping, activation timing, voltage mapping, and entrainment mapping along with selective ablation targeted to the critical isthmi yields excellent (90%) arrhythmia-free medium-term survival.

RAPID COMMUNICATION

Open Access

A Novel Technique for Diaphragmatic Compound Motor Action Potential Monitoring Using the BeeAT Catheter During Cryoballoon Ablation for Atrial Fibrillation

  • First Published: 28 July 2025
A Novel Technique for Diaphragmatic Compound Motor Action Potential Monitoring Using the BeeAT Catheter During Cryoballoon Ablation for Atrial Fibrillation

Compound motor action potential (CMAP) signals were sharp and stable, with minimal pacing artifacts and far-field ventricular waves. Diaphragmatic CMAP monitoring using a BeeAT catheter positioned in the subdiaphragmatic inferior vena cava appears to offer a feasible and effective approach during cryoballoon ablation.

SPOTLIGHT

Open Access

Dual Chamber Open Window Mapping and High-Density Mapping for Atrioventricular Reentrant Tachycardia Associated With Atrioventricular Mahaim Fiber

  • First Published: 24 July 2025
Dual Chamber Open Window Mapping and High-Density Mapping for Atrioventricular Reentrant Tachycardia Associated With Atrioventricular Mahaim Fiber

Dual-chamber open-window mapping (OWM) combined with high-density mapping revealed early atrioventricular conduction on the lateral tricuspid annulus, consistent with a Mahaim fiber. Catheter ablation targeting the ventricular insertion site led to successful elimination of the accessory pathway and noninducibility of tachycardia.

Open Access

Successful Ethanol Infusion of Vein of Marshall With Bridge Collateral Using the Double-Balloon Technique Incorporating a Wedged Berman Catheter

  • First Published: 22 July 2025
Successful Ethanol Infusion of Vein of Marshall With Bridge Collateral Using the Double-Balloon Technique Incorporating a Wedged Berman Catheter

We describe a novel double-balloon technique incorporating a wedged Berman catheter to manage distal collateral drainage from the vein of Marshall (VOM) via a bridge collateral to the great cardiac vein, thereby enabling effective ethanol infusion. This technique may represent a viable alternative for anatomically challenging VOM ethanol infusion cases.

Open Access

First Report of Focal Atrial Tachycardia Originating From the Left Atrial Appendage in a 13-Year-Old Girl Treated Using the OPTRELL Multipolar Mapping Catheter

  • First Published: 22 July 2025
First Report of Focal Atrial Tachycardia Originating From the Left Atrial Appendage in a 13-Year-Old Girl Treated Using the OPTRELL Multipolar Mapping Catheter

Safe and effective mapping of focal atrial tachycardia from the left atrial appendage using an array catheter enabled successful ablation in a pediatric patient without complications.

SPOTLIGHT

Open Access

Technical Tips and Efficacy of Leadless Pacemaker Implantation in a Patient With Isolated Persistent Left Superior Vena Cava

  • First Published: 18 July 2025
Technical Tips and Efficacy of Leadless Pacemaker Implantation in a Patient With Isolated Persistent Left Superior Vena Cava

Isolated persistent left superior vena cava (PLSVC) provides limited access during transvenous pacemaker implantation. We present a case of implantation of a leadless pacemaker for atrioventricular block with isolated PLSVC. A leadless pacemaker is an alternative strategy to a transvenous pacemaker; however, some technical tips are required: (1) the prevention of the mis-insertion in the dilated coronary sinus and (2) the pre-assessment of the anatomy of the right atrium and ventricle.

ORIGINAL ARTICLE

Open Access

Long-Term Safety of Extremely Low-Dose Amiodarone at 50 mg Daily in Patients With Persistent Atrial Fibrillation

  • First Published: 17 July 2025
Long-Term Safety of Extremely Low-Dose Amiodarone at 50 mg Daily in Patients With Persistent Atrial Fibrillation

The use of extremely low-dose amiodarone (50 mg once daily) was safe and effective in Japanese patients with persistent AF. A low baseline KL-6 level may indicate patients at lower risk for amiodarone-related interstitial pneumonia.

Open Access

Prognostic relevance of arrhythmic and QTc burden in takotsubo cardiomyopathy: A systematic review and meta-analysis

  • First Published: 16 July 2025
Prognostic relevance of arrhythmic and QTc burden in takotsubo cardiomyopathy: A systematic review and meta-analysis

The objective of the study was to evaluate the prognostic implications of the arrhythmic and QTc burden in Takotsubo cardiomyopathy. We found that atrial arrhythmias and ventricular arrhythmias significantly increased in-hospital morbidity and mortality, while prolonged QTc only increased in-hospital morbidity. It is critically important to recognize this high-risk and unique subset of Takotsubo patients in order to optimally treat and improve clinical outcomes.

SPOTLIGHT

Open Access

Pacing Pandemonium: The Unexpected Outcome of Temporary Pacing

  • First Published: 16 July 2025
Pacing Pandemonium: The Unexpected Outcome of Temporary Pacing

This case report describes the first occurrence of capture of the left bundle branch by a temporary pacing catheter that inadvertently perforated the interventricular septum during a transcatheter aortic valve implantation.

ORIGINAL ARTICLE

Open Access

Extra-cardiac vagal stimulation: Clinical utility of a novel diagnostic and therapeutic tool in supraventricular tachycardia

  • First Published: 15 July 2025
Extra-cardiac vagal stimulation: Clinical utility of a novel diagnostic and therapeutic tool in supraventricular tachycardia

Extracardiac vagal stimulation (ECVS) is a novel, safe tool inducing controlled AV/VA block. It assists SVT differential diagnosis, pathway unmasking, and ablation endpoint confirmation, adding value to EP procedures for supraventricular tachycardias.

Open Access

Cardiac arrhythmias in cancer patients using the nationwide claim-based database in Japan

  • First Published: 15 July 2025
Cardiac arrhythmias in cancer patients using the nationwide claim-based database in Japan

The prevalence of cancer increased with time in view of cardio-oncology or oncocardiology, which has organically developed as a new discipline. The data showed similar patterns of distribution in patients with both arrhythmias and ischemic heart diseases.

ORIGINAL ARTICLE

Open Access

Early Deterioration of the Right Ventricular Pacing Threshold Predicts the Increase in His-Bundle Pacing Threshold During the Chronic Phase: A Single-Center Retrospective Study

  • First Published: 15 July 2025
Early Deterioration of the Right Ventricular Pacing Threshold Predicts the Increase in His-Bundle Pacing Threshold During the Chronic Phase: A Single-Center Retrospective Study

We observed that an increase in the right ventricular (RV) pacing threshold tended to precede that of the His-bundle threshold. Multivariate analysis identified two predictors of chronic threshold deterioration: an RV pacing threshold ≥ 3.0 V/0.4 ms at 1 week after implantation and the lead shape at the time of implantation.

Open Access

A study of the clinical usefulness of the eMEMO®

  • First Published: 09 July 2025
A study of the clinical usefulness of the eMEMO®

Taking advantage of the characteristics of the novel compact external loop recorder (ELR; eMEMO®), we investigated the usefulness of ELR measurement. As a result, the patch-type ELR, which is waterproof and can continuously record regardless of restrictions such as bathing or exercise, is useful for detecting stable arrhythmias in patients.

Open Access

Differing impacts of cardiac implantable electronic device leads on tricuspid regurgitation

  • First Published: 07 July 2025
Differing impacts of cardiac implantable electronic device leads on tricuspid regurgitation

This study evaluates the impact of different CIED lead types (ICD, RV-PM, His-PM) on the progression of tricuspid regurgitation (TR). The effect of CIED leads on TR grade represents a spectrum related to the type of lead traversing the tricuspid valve.

Open Access

AI-ECG for early detection of atrial fibrillation: First-year results from a stroke prevention study in Shimizu, Japan

  • First Published: 04 July 2025
AI-ECG for early detection of atrial fibrillation: First-year results from a stroke prevention study in Shimizu, Japan

AI-ECG risk classification in a community-based health screening program was associated with AF detection through 7-day monitoring. Detection rates increased with risk level, especially in older adults, supporting its potential as a population-based screening tool.

SPOTLIGHT

Open Access

Unforeseen beneficial effect of successful PVC ablation: Achieving migraine attack control without medication

  • First Published: 04 July 2025
Unforeseen beneficial effect of successful PVC ablation: Achieving migraine attack control without medication

Successful catheter ablation of frequent PVCs in a patient with PVC-induced cardiomyopathy resulted in a marked improvement in left ventricular ejection fraction (LVEF), accompanied by complete resolution of migraine with aura attacks. This case illustrates both cardiac and neurological benefits of PVC burden reduction through ablation.

ORIGINAL ARTICLE

Open Access

Return-to-play in athletes with transvenous and subcutaneous implantable cardiac defibrillator: A meta-analysis

  • First Published: 02 July 2025
Return-to-play in athletes with transvenous and subcutaneous implantable cardiac defibrillator: A meta-analysis

This meta-analysis of six cohort studies (n = 1,183) found that athletes with transvenous or subcutaneous ICDs had 13% appropriate and 4% inappropriate shock rates, with no serious adverse events. Findings support individualized return-to-play decisions, considering arrhythmia type, ICD programming, and psychological support.

RAPID COMMUNICATION

Open Access

Impact of tablet-induced electromagnetic interference on abdominal cardiac devices: A study based on simulated patients

  • First Published: 02 July 2025
Impact of tablet-induced electromagnetic interference on abdominal cardiac devices: A study based on simulated patients

While a magnetic flux density of 10 Gauss could potentially cause electromagnetic interference, tablets have a magnetic flux density exceeding 600 Gauss. Tablets may generate a sufficiently strong magnetic flux density to interfere with cardiac devices implanted in the abdomen.

ORIGINAL ARTICLE

Open Access

Intracardiac echocardiography versus transesophageal echocardiography guidance on left atrial appendage occlusion in patients with atrial fibrillation: A systematic review and meta-analysis

  • First Published: 01 July 2025
Intracardiac echocardiography versus transesophageal echocardiography guidance on left atrial appendage occlusion in patients with atrial fibrillation: A systematic review and meta-analysis

ICE is a viable alternative to TEE for guiding LAAO in atrial fibrillationpatients unable to tolerate anti-coagulants, especially those unfit for general anesthesia. It offers high procedural success, reduced device use, and comparable safety, though with a slightly increased risk of pericardial effusion.

Open Access

Impact of magnetic fields from tablets, laptops, smartphones, and household/leisure magnets on cardiac implantable electronic devices

  • First Published: 30 June 2025
Impact of magnetic fields from tablets, laptops, smartphones, and household/leisure magnets on cardiac implantable electronic devices

This study on 13 Cardiac implantable electronic device (CIED) models revealed that surface magnetic fields of tablets, laptops, smartphones, and household magnets exceeded 10 G, potentially triggering magnet response mode. Activation occurred at ≤15 mm for electronic devices and ≤7 mm for household magnets. Magnet response was not observed >18 mm. These findings underscore the risk of unintended magnet response at close proximity, necessitating patient education and healthcare professional awareness regarding safe device use and variable magnet mode operation across CIED manufacturers.

ORIGINAL ARTICLE

Open Access

Clinical feasibility of high-power short-duration strategy at the sites adjacent to the esophagus during laser balloon-based pulmonary vein isolation

  • First Published: 30 June 2025
Clinical feasibility of high-power short-duration strategy at the sites adjacent to the esophagus during laser balloon-based pulmonary vein isolation

We enrolled 50 ablation sites (12, 10, 8.5, and 5.5 W) in 11 patients where the esophageal temperature reached 39°C within 5 s after ablation. Although ablation duration was correlated with power settings, total energy and maximal esophageal temperature did not differ significantly among the 4 groups.

ORIGINAL ARTICLE

Open Access

Mid-term effects on sinus node function following additional empirical superior vena cava isolation in atrial fibrillation patients with sick sinus syndrome

  • First Published: 30 June 2025
Mid-term effects on sinus node function following additional empirical superior vena cava isolation in atrial fibrillation patients with sick sinus syndrome

The comparison of long-term sinus node function between atrial fibrillation (AF) patients with sick sinus syndrome (SSS) who underwent pulmonary vein isolation (PVI) alone versus those who received additional empirical superior vena cava isolation (SVCI). At 36 months following the final ablation procedure, no significant differences were observed between the groups in terms of minimum heart rate, maximum sinus pause duration, or pacemaker implantation avoidance rate.

SPOTLIGHT

Open Access

Successful left atrial access through GORE CARDIOFORM ASD occluder using an integrated transseptal wire system after failed RF needle approach

  • First Published: 30 June 2025
Successful left atrial access through GORE CARDIOFORM ASD occluder using an integrated transseptal wire system after failed RF needle approach

An integrated transseptal wire system enabled successful left atrial access through the elastic resistance posed by a large GORE CARDIOFORM ASD occluder after failed RF needle attempt, allowing large-bore cryoballoon sheath advancement via sequential sheath technique for atrial fibrillation ablation without procedural complications.

Open Access

Successful debulking of vegetation extending into the right ventricle using a steerable sheath and leadless retrieval system

  • First Published: 30 June 2025
Successful debulking of vegetation extending into the right ventricle using a steerable sheath and leadless retrieval system

Lead-associated endocarditis, characterized by large vegetations, poses a significant risk of embolization during transvenous lead extraction, necessitating surgical intervention that may be contraindicated in critically ill patients. We describe a successful catheter-based debulking of massive vegetation extending to the right ventricular apex using a steerable sheath and leadless retrieval system.

Open Access

Left atrial intramural hematoma following right atrial catheter ablation: A rare case involving coronary sinus injury

  • First Published: 30 June 2025
Left atrial intramural hematoma following right atrial catheter ablation: A rare case involving coronary sinus injury

Left atrial intramural hematoma (LAIH) is an exceedingly rare complication that occurs following catheter ablation in the right atrium. The present case is the first to implicate coronary sinus catheter manipulation—rather than left atrial intervention—as a potential mechanism of LAIH.

ISSUE INFORMATION

Open Access

Issue Information

  • First Published: 29 June 2025