The wide spectrum of MOG-associated CNS demyelination, including monophasic and relapsing forms, seems to be now better understood. Although most children have a good clinical outcome, MOGAD may be a severe relapsing and devastating disorder for a subgroup of patients. Considering the moderate response to current standard relapse prevention therapies additional safe and long-term efficacious treatment options are still much needed for children with relapsing MOG demyelination.

This review summarizes the current understanding of acute and chronic treatments for MOGAD. Timing and duration of treatment, pregnancy, and emerging therapies are also discussed.

In this review, we discuss the clinical and paraclinical features of immunoglobulin G serum antibodies against myelin oligodendrocyte glycoprotein-positive optic neuritis in adults, and focus on the distinctive features that can enable its early diagnosis. Therapeutical considerations at the acute stage and for relapse prevention are further deliberated.

This review aims to describe two cases of Balò’s Concentric Sclerosis (BCS) and to review the state-of-the-art literature. Through the analysis of current imaging practice, our purpose is to help clinicians reach early diagnosis, thus enhancing the chances of a more successful outcome for the patients.

This case was a very rare case of lenalidomide-associated progressive multifocal leukoencephalopathy.

A case of a 46-year-old Filipino female with subacute onset of memory loss, behavioral changes, seizures, and hyponatremia. Workup showed elevated titers of antibodies against voltage-gated potassium channel complex. Intravenous steroid therapy was administered that reversed the neurocognitive disorders.