Nebulized inhalation of inactivated Mycobacterial vaccine will be an effective therapy for the prevention and treatment of respiratory diseases.

Schematic diagram of two-sample Mendelian randomization analysis.

The analysis of the effects of acupoint catgut embedding therapy on asthma control, sleep quality, as well as immune and inflammatory factors. Univariate and multivariate analysis of the effects of acupoint catgut embedding therapy.

Telomerase abnormalities such as related gene mutations lead to decrease in telomerase activity and telomere shortening. Individual cells undergoing continuous division exhibit telomere shortening. A successive shortening of the telomere results in dysfunctional telomeres. This induces replicative senescence of alveolar epithelial cells and ultimately progress to pulmonary fibrosis.

• This study determined the effect of hypothyroidism on IPF using a two-sample MR approach.
• Mediating effects of immune cells were assessed using the coefficient product method.
• Hypothyroidism significantly increased the risk of developing IPF.
• CD19 on IgD− CD27− and HVEM on T cells were identified as critical mediators.
• Hypothyroidism likely contributes to IPF pathogenesis through immune dysregulation.

This Mendelian randomization study revealed a causal association between genetically predicted cystatin 8 and squamous cell lung carcinoma, while Cystatin D was linked to lung adenocarcinoma after outlier adjustment. The findings suggest cystatins may play distinct roles in lung cancer subtypes, calling for further investigation to confirm these relationships.

This meta-analysis of 115 studies showed common metastatic sites for NSCLC as brain (29%), bone (25%), and adrenal gland (15%); for SCLC, they were liver (33%), brain (30%), and bone (27%). PCI reduced brain metastasis in both cancers. Median OS after brain metastasis was 21.3 months (NSCLC) and 10.5 months (SCLC). Liver and bone metastases worsened survival.

EIT-guided personalized airway clearance significantly improves outcomes in elderly severe pneumonia patients. Real-time electrical impedance tomography (EIT) optimized secretion clearance through dynamic adjustment of posture, percussion, and breathing techniques. This approach enhanced respiratory mechanics, oxygenation, and infection control, doubling extubation success rates (88% vs. 56%) compared with standard fixed-schedule therapy.

This study assessed the effect of switching from dual bronchodilator therapy to triple therapy in COPD. While FEV1 showed no significant change, resonant frequency improved, suggesting reduced airway inflammation. Impulse oscillometry may help detect treatment effects not captured by spirometry.

In contrast to findings from previous COVID-19 Delta waves, COPD was not independently associated with increased risk of adverse outcomes in patients hospitalized with Omicron variant infection. These findings suggest a significant shift in risk profiles during the Omicron wave, potentially reflecting the variant's altered pathogenicity, evolving treatment approaches, and vaccination impacts.

OM-85 reduced the size of high-risk pulmonary nodules and decreased the risk of malignant probability and disease progression by increasing the proportion of NK cells. Therefore, OM-85 may be a potential agent for the treatment of high-risk pulmonary nodules.

In this work, we present a case of allergic bronchopulmonary aspergillosis. High-resolution computed tomography (HRCT) of the chest revealed diffuse lung lesions. Additionally, arterial blood gas analysis indicated life-threatening acute Type II respiratory failure.

The core EGF gene variants in string interaction network rs1897990 and rs1524106 are significant risk factors for lung adenocarcinoma in young individuals, particularly when combined with smoking. Tobacco use appears to potentiate the oncogenic effects of these variants, further increasing susceptibility to early-onset lung adenocarcinoma.

FE_NO was negatively correlated with pre-bronchodilator FEV₁ (L and % predicted) pre- and post-bronchodilator FEV₁/FVC ratio, and positively correlated with bronchodilator reversibility (mL and %), as well as baseline blood eosinophil level by absolute cell count and percentage.