The positive expression of CR-1 protein in early stage NSCLC was higher than that in normal lung tissue. Cox multivariate regression analysis showed that the expression of CR-1 protein was an independent prognostic factor for early stage NSCLC. Detecting the expression of CR-1 protein is helpful to predict the prognosis and recurrence of early stage NSCLC patients.

Prostacyclin pathway agents are effective in improving health outcomes in pulmonary arterial hypertension patients. Availability of oral prostacyclin pathway agents such as selexipag have the potential to benefit patients with less advanced disease. We sought to assess the impact of early selexipag use on hospitalization rates and medical costs in real-world clinical practice.

The present study revealed that miR-23a-3p repressed cigarette smoke-induced emphysema in mice and CSE-induced PMVECs apoptosis by targeting DNAJB1.

SCN4B encoding voltage-gated sodium channel β subunit is regarded as metastasis-suppressor gene, and it expresses higher in normal samples than lung adenocarcinoma (LUAD) samples. SCN4B is an independent prognostic signature for LUAD patients, and its higher expression in LUAD samples represents better prognosis. Transcription factors TAL1 and ERG may regulate the expression of SCN4B by binding its upstream sequences.

The detection rate of EBV-DNA in the lower respiratory tract was high. When patients have positive EBV-DNA results in the lower respiratory tract, their disease is often more severe. EBV-DNA-positive and low lymphocyte count are independent risk factors for the development of moderate-to-severe ARDS in patients with influenza A-related pneumonia.

Of the 8912 studies that identified, 58 RCTs met the inclusion criteria and involved 12 961 participants. The pooled incidences of total AEs and severe AEs in patients treated with salbutamol were 34% and 2%, respectively. The most frequently observed specific AEs was palpitations or tachycardia.

Menthol could display an inhibitory effect on A549 cells through Akt signaling pathway, and menthol might be a potential target for NSCLC treatment.

The association between IL10 rs1800896 polymorphisms and pediatric asthma risk was evaluated using a meta-analysis. A total of 12 studies with 1645 cases and 1447 controls were included. It was found that IL10 rs1800896 polymorphism was not significantly associated with risk of childhood asthma in all genetic models studied, although subgroup analysis revealed that the polymorphism was significantly associated with a lower risk of pediatric asthma in Asians.

HLA-DMA is a TME monitor related to LUAD prognosis. HLA-DMA may suspend cell proliferation by regulating cell cycle. Patients with high HLA-DMA level are more sensitive for immunotherapy. HLA-DMA is a biomarker for immune infiltration and immunotherapy response in LUAD.

TOP2A and ADH1B were identified as the only genes up- and down-regulated in both LUAD and LUSC. TOP2A and ADH1B can be used as diagnostic markers for LUAD and LUSC, but only as independent prognostic factors for LUAD, and may be involved in lipid metabolism in LUAD patients but not in LUSC.

Cigarette smoke inhibited allergen-induced airways hyperrespinsiveness, changed inflammation ‘phenotypes’, while accelerated airways remodelling.

A comparison of ILD-DM and Non-ILD-DM revealed significant differences in IgG, IgA and IgM. Meanwhile, significant differences in IL-6, IL-10, IL-17, DP cell ratio and B lymphocyte ratio found when comparing PH-DM and Non-PH-DM.

The study suggests that the improved uniportal thoracoscopic bullectomy with parietal pleurectomy technique had satisfactory perioperative results, which was safe and potentially effective in reducing recurrence rates of PSP.

The prognostic signature in LUAD was constructed according to BTK, FGFR2, PIM2, CHEK1, and CDK1. The LUAD patients in high-risk group exhibited a poor prognosis. The risk score model was a potential prognostic biomarker for LUAD patients.

We report a case of hepatoid adenocarcinoma with the primary lesion located in the left upper lung. The patient was treated by four cycles of combined therapy, and the tumour had significantly reduced in size. Subsequent postoperative pathology proved that the patient had achieved a complete remission.