• Issue

    Basic & Clinical Pharmacology & Toxicology: Volume 125, Issue 2

    85-186
    August 2019
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Issue Information

Free Access

Issue Information

  • Pages: 85-86
  • First Published: 16 July 2019

EDITORIAL

Proton pump inhibitors: New mechanisms of action

Jose E. Tanus-Santos,  Lucas C. Pinheiro, 
  • Pages: 87-88
  • First Published: 13 April 2019

ORIGINAL ARTICLES

Basic Pharmacology

Lansoprazole inhibits the cysteine protease legumain by binding to the active site

Tatjana Bosnjak,  Rigmor Solberg,  Paya Diana Hemati,  Abbas Jafari,  Moustapha Kassem,  Harald Thidemann Johansen, 
  • Pages: 89-99
  • First Published: 27 March 2019

Clinical Pharmacology

Physiologically based pharmacokinetic modelling to predict exposure differences in healthy volunteers and subjects with renal impairment: Ceftazidime case study

Li Zhou,  Xiao Tong,  Pradeep Sharma,  Hongmei Xu,  Nidal Al-Huniti,  Diansong Zhou, 
  • Pages: 100-107
  • First Published: 09 February 2019

Differences in preventing new-onset cardiovascular events with statin therapy in seniors aged 75 years and over: A cohort study in the South Korean National Health Insurance Database

Kyungim Kim,  Arim Kwak,  Cheol Ung Choi,  Jae Hyun Kim,  Myeong Gyu Kim,  Jung Mi Oh,  Eunhee Ji, 
  • Pages: 108-116
  • First Published: 28 March 2019

Decreased Cytochrome P450 3A activity in palliative patients with haematological diseases: Potential impact on supportive drug therapies

Marcus J. P. Geist,  Nelly Siller,  Gerlinde Egerer,  Hubert Bardenheuer,  Juergen Burhenne,  Gerd Mikus, 
  • Pages: 117-122
  • First Published: 27 March 2019

Laparoscopic Roux-en-Y gastric bypass surgery influenced pharmacokinetics of several drugs given as a cocktail with the highest impact observed for CYP1A2, CYP2C8 and CYP2E1 substrates

Elena Puris,  Markku Pasanen,  Veli-Pekka Ranta,  Mikko Gynther,  Aleksanteri Petsalo,  Pirjo Käkelä,  Ville Männistö,  Jussi Pihlajamäki, 
  • Pages: 123-132
  • First Published: 27 March 2019
Open Access

Pharmacokinetics of ferric bepectate—a new intravenous iron drug for treating iron deficiency

Manuel Muñoz,  Peter Skov Olsen,  Tonny Studsgaard Petersen,  Susanne Manhart,  Stig Waldorff, 
  • Pages: 133-141
  • First Published: 06 March 2019

Basic Toxicology

Wuzhi capsule regulates chloroacetaldehyde pharmacokinetics behaviour and alleviates high-dose cyclophosphamide-induced nephrotoxicity and neurotoxicity in rats

Li Chen,  Xiaojuan Xiong,  Xingyun Hou,  Hua Wei,  Jianxiu Zhai,  Tianyi Xia,  Xiaobin Gong,  Shouhong Gao,  Ge Feng,  Xia Tao,  Feng Zhang,  Wansheng Chen, 
  • Pages: 142-151
  • First Published: 21 February 2019

Fasudil alleviates brain damage in rats after carbon monoxide poisoning through regulating neurite outgrowth inhibitor/oligodendrocytemyelin glycoprotein signalling pathway

Li Wang,  Jianghua Xu,  Dadong Guo,  Xudong Zhou,  Wenwen Jiang,  Jinglin Wang,  Jiyou Tang,  Yong Zou,  Mingjun Bi,  Qin Li, 
  • Pages: 152-165
  • First Published: 27 March 2019

Lung alveolar tissue destruction and protein citrullination in diesel exhaust-exposed mouse lungs

Ieva Kulvinskiene,  Jovile Raudoniute,  Edvardas Bagdonas,  Darius Ciuzas,  Karina Poliakovaite,  Inga Stasiulaitiene,  Danguole Zabulyte,  Daiva Bironaite,  Petras Rimantas Venskutonis,  Dainius Martuzevicius,  Ruta Aldonyte, 
  • Pages: 166-177
  • First Published: 24 February 2019

Clinical Toxicology

Clinical toxicology of beta-blocker overdose in adults

Michael Lauterbach, 
  • Pages: 178-186
  • First Published: 27 March 2019