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Cover Picture
Biomimetics: Small 9/2010
- First Published: 11 May 2010

The cover image shows a scanning electron microscopy image of bioinspired subwavelength structures (SWS) with parabolic shape, which are fabricated by simple process steps based on the combination of laser interference lithography, thermal reflow, and subsequent pattern transfer. The insets depict the reflected light from the flat surface (top) and parabola-shaped SWS (bottom), respectively. The fabricated SWS with parabolic shape show antireflection properties over a broader wavelength range compared to that of a flat surface and even conventional cone-shaped SWS, thus opening up new possibilities for various optoelectronic device applications to improve optical performance. For more information, please read the Communication “Bioinspired Parabola Subwavelength Structures for Improved Broadband Antireflection” by Y. T. Lee el al., beginning on page 984.
Inside Cover
Heteroepitaxy: Small 9/2010
- First Published: 11 May 2010

The cover picture shows electron microscopy images of the produced nanoscale shell/fiber superstructure TiO2 on cryptomelane MnO2 (OMS-2) in a single-step aqueous reaction. Control of the nanostructure and orientation of materials is important but complicated in current nanotechnological applications. The discovery of size, shape, and array controls of TiO2 nanomaterials via heteroepitaxy offers a much simpler way to produce complex nanomaterials. The mechanism study shows that the nanoshell is formed prior to the surface nanofibers. The whole growth process is highly dependent on the interface misfits of materials. Thus, selected preparation of nanoshell or shell/fiber nanostructure is allowed for many materials research needs. This unique heteroepitaxy relationship is general for rutile oxides and potentially general for many different tunnel oxides. For more information, please read the Communication “Heteroepitaxial Growth of Nanoscale Oxide Shell/Fiber Superstructures by Mild Hydrothermal Processes” by S. L. Suib et al., beginning on page 988.
Contents
Communications
Biomimetics
Bioinspired Parabola Subwavelength Structures for Improved Broadband Antireflection†
- Pages: 984-987
- First Published: 11 May 2010

Subwavelength structures (SWSs) with a parabola shape are fabricated by a combination of laser interference lithography of a photoresist (PR), thermal reflow, and subsequent pattern transfer. The SWSs show antireflection properties in a broader wavelength range than conventional cone-shaped SWSs, and have potential in optoelectronics for improved device performance.
Heteroepitaxy
Heteroepitaxial Growth of Nanoscale Oxide Shell/Fiber Superstructures by Mild Hydrothermal Processes†
- Pages: 988-992
- First Published: 11 May 2010
Biosensors
Direct Detection of Heroin Metabolites Using a Competitive Immunoassay Based on a Carbon-Nanotube Liquid-Gated Field-Effect Transistor†
- Pages: 993-998
- First Published: 11 May 2010

A carbon-nanotube-based liquid-gated field-effect transistor is employed for the detection of heroin narcotics. Detection of monoacetylmorphine down to 15 pg mL−1 is accomplished by means of a competitive immunoassay protocol in conjunction with charged Au nanoparticles that augment the electrostatic perturbance generated from the receptor–ligand interaction coupled with the carbon nanotubes.
Biological nanoreactors
Biomimetic Crystallization of Sulfide Semiconductor Nanoparticles in Aqueous Solution†
- Pages: 999-1002
- First Published: 11 May 2010

A new biomimetic approach is introduced for quantum-dot synthesis in aqueous solution. The sulfide concentration gradient around the nucleating urease is controlled by the degree of inhibition of the catalytic activity, and the optimized precursor gradient on the enzyme generates monodisperse and crystalline sulfide semiconductor nanoparticles.
Full Papers
Drug delivery
One-Step Fabrication of Triple-Layered Polymeric Microparticles with Layer Localization of Drugs as a Novel Drug-Delivery System
- Pages: 1003-1011
- First Published: 11 May 2010

Triple-layered microparticles are fabricated through a simple, versatile, one-step solvent evaporation technique. Control of the layer thickness and microparticle configurations, as well as drug localization in different layers, can be achieved. This microparticle design would allow for specific tailoring of particulate drug-delivery systems to suit a wide range of applications.
Gold nanostructures
Microbial Synthesis of Multishaped Gold Nanostructures
- Pages: 1012-1021
- First Published: 11 May 2010

A simple, protein-mediated, green chemical methodology is proposed for the synthesis of multishaped (triangular, hexagonal, pentagonal, spherical, spheroidal, urchinlike, two-dimensional nanowires, and nanorods) gold nanostructures. The proteins function as a reducing, shape directing, and stabilizing agent.
Drug delivery
Near-Infrared Light Triggers Release of Paclitaxel from Biodegradable Microspheres: Photothermal Effect and Enhanced Antitumor Activity
- Pages: 1022-1031
- First Published: 11 May 2010
Nanowire nucleation
Gold-Catalyzed Vapor–Liquid–Solid Germanium-Nanowire Nucleation on Porous Silicon
- Pages: 1032-1037
- First Published: 11 May 2010

Porous Si substrates, which have greater effective interparticle separations for Au surface diffusion than nonporous Si, inhibit gold catalyst particle coarsening and agglomeration prior to vapor–liquid–solid nanowire nucleation. This increases the yield and greatly reduces the variation in wire diameter and length compared to nucleation on nonporous Si.
Metal-enhanced fluorescence
Tuning the Intensity of Metal-Enhanced Fluorescence by Engineering Silver Nanoparticle Arrays
- Pages: 1038-1043
- First Published: 11 May 2010

Metal-enhanced fluorescence (MEF) is widely employed in high-sensitivity detection. In this work, the effect of pattern features of silver nanoparticle (SNP) arrays on MEF is investigated. It is shown that the intensity of MEF can be tuned by varying the SNP arrays. Strong MEF can be achieved by adjusting the pattern features.
Gold nanoparticles
Inhibition of HSV-1 Attachment, Entry, and Cell-to-Cell Spread by Functionalized Multivalent Gold Nanoparticles
- Pages: 1044-1050
- First Published: 11 May 2010

Gold nanoparticles capped with mercaptoethanesulfonate are shown to block HSV-1 infection by virtue of their ability to mimic cell surface heparan sulfate receptors, which are the primary binding site for the virus during the infection cycle. A mechanistic insight reveals efficient blockage of virus attachment, entry, and cell-to-cell spread by the nanoparticles.
Microfluidics
Formation of Bubbles in a Multisection Flow-Focusing Junction
- Pages: 1051-1059
- First Published: 11 May 2010

The formation of bubbles in a flow-focusing (FF) junction comprising multiple rectangular sections is described. The investigation of the influence of the flow of liquid and of the geometry of the FF junction on the formation of bubbles identifies different mechanisms that lead to the generation of monodisperse, bidisperse, and tridisperse sets of bubbles reproducibly.
Nanotechnology
Digital and FM Demodulation of a Doubly Clamped Single-Walled Carbon-Nanotube Oscillator: Towards a Nanotube Cell Phone
- Pages: 1060-1065
- First Published: 11 May 2010

Digital, FM, and AM demodulation is performed with a carbon-nanotube nanoelectromechanical resonator in a field-effect-transistor configuration. The DC voltage at the gate plays the role of a tuner. This device performs at a digital transfer rate of 10 kbt s−1, which is compatible with GSM requirements..
Corrigendum
Corrigendum: Three-Dimensional Fabrication at Small Size Scales
- First Published: 11 May 2010