PEG-functionalized anti-IL4Rα-conjugated SPIONs allowed enhanced targeting of IL4Rα asthma biomarker in the lung. Noninvasive free-breathing UTE-MRI allowed monitoring of the developed magnetic nanocarriers, which co-localized with the inflammatory sites. Enhanced targeting to areas rich in IL4Rα positive inflammatory cells was confirmed using histological analyses

While the T₂^* shortening effect arising from the encapsulated iron oxide nanoparticles into the nanocarrier allow or detect the presence of thermosensitive liposome carrier, its content release could have been characterized based on the independent T₁ or T₂ shortening gadolinium release-induced effect.

RF power-based ratiometric analysis of spillover effect-corrected inverse CEST asymmetry (PRICEST) provides enhanced pH measurement over the recently proposed RF power-based ratiometric (PRCEST) imaging. The difference between MRI-determined pH (pHMRI) and electrode-measured pH is 0.12±0.13 and 0.04±0.03 for PRCEST and PRICEST imaging, respectively. The derived labile proton ratio linearly scales with creatine concentration, and the exchange rate shows dominantly base-catalyzed relationship with pH, independent of creatine concentration. Hence, PRICEST quantitative CEST MRI augments pH imaging.

Microwave-driven synthesis enables one step, ⁶⁸Ga core-doping of iron oxide nanoparticles as platform for targeted molecular PET/T1-M imaging.

After intravenous injection of USPIOs conjugated with a MUC5AC-specific peptide, negative T₂ weighted contrast in MR images was generated by the specific binding to MUC5AC.

SIRB is a new cross-linked dextran nanoparticle that does not contain Fe₃O₄. SIRB is designed to provide all of the cell labeling properties of the ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle Molday ION Rhodamine B (MIRB). SIRB possesses a similar size, charge, and cross-linked dextran coating to MIRB. SIRB does not alter cellular viability, proliferation, or differentiation. SIRB can be used to label cells as a control to check the toxicity of the surface coating surrounding the iron oxide core.

A cationic gadolinium complex that can electrostatically interact with Glycosaminoglycans was synthesized to improve the delineation of fine tears within cartilage.

We evaluate transferrin receptor-1 (TfR1) as an MR reporter gene in the model cell line CHO-K1. Although under standard culture conditions iron levels increase significantly on overexpression of this gene, we found that medium supplementation with iron sources results in dramatically higher levels of intracellular iron and MR contrast, irrespective of the reporter. We conclude that TfR1 is not an effective reporter, and that for short-term cell tracking it is sufficient to simply supplement culture medium with ferric citrate.

We report on three patients with impaired renal function and vascular calcification (two with confirmed nephrogenic systemic fibrosis) whose unenhanced T1-weighted MRIs showed conspicuous high signal intensity in the dentate nucleus and the globus pallidus after they had been exposed to relatively low doses of linear gadolinium-based contrast agents (0.27, 0.45, and 0.68 mmol/kg). Of note, all three analysed patients suffered from transient signs of neurological disorders of undetermined cause.