• Issue

    Hepatology: Volume 61, Issue 4

    1101-1448
    April 2015
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Hepatology Highlights

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Hepatology highlights

Jean-François Dufour, 
  • Pages: 1101-1103
  • First Published: 20 February 2015

Comments from the Editor

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What is Hepatology looking for?

Michael H. Nathanson M.D., Ph.D., 
  • Pages: 1104-1105
  • First Published: 10 January 2015

Editorials

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Costly choices for treating Wilson's disease

Michael L. Schilsky M.D.,  Eve A. Roberts M.D., M.A., F.R.C.P.C.,  Sihoun Hahn M.D., Ph.D.,  Frederick Askari M.D., Ph.D., 
  • Pages: 1106-1108
  • First Published: 18 December 2014
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Pegylated interferon therapy of chronic hepatitis D: In need of revision

Mario Rizzetto M.D., PH.D.,  Antonina Smedile M.D., 
  • Pages: 1109-1111
  • First Published: 28 October 2014
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A monocytic detour to replicate patient-derived hepatitis C virus in hepatoma cells and its use for phenotypic analyses

Laurent Chatel-Chaix Ph.D.,  Ralf Bartenschlager Ph.D., 
  • Pages: 1112-1114
  • First Published: 21 November 2014
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The “dose” of exercise and its effects beyond weight loss

Mary E. Rinella M.D., 
  • Pages: 1115-1117
  • First Published: 24 December 2014
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Sphingosine-1-phosphate receptor 2: A novel bile acid receptor and regulator of hepatic lipid metabolism?

John Y.L. Chiang Ph.D., 
  • Pages: 1118-1120
  • First Published: 22 November 2014
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Interplay of interleukin-22 and its binding protein in controlling liver scarring

Bin Gao M.D., Ph.D., 
  • Pages: 1121-1123
  • First Published: 10 January 2015
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Modeling idiosyncrasy: A novel animal model of drug-induced liver injury

Gwilym J. Webb B.M. B.Ch., M.R.C.P.,  David H. Adams M.D., F.R.C.P., F.Med.Sci., 
  • Pages: 1124-1126
  • First Published: 22 November 2014

Rapid Communication

Open Access

All-oral 12-week treatment with daclatasvir plus sofosbuvir in patients with hepatitis C virus genotype 3 infection: ALLY-3 phase III study

David R. Nelson,  James N. Cooper,  Jacob P. Lalezari,  Eric Lawitz,  Paul J. Pockros,  Norman Gitlin,  Bradley F. Freilich,  Ziad H. Younes,  William Harlan,  Reem Ghalib,  Godson Oguchi,  Paul J. Thuluvath,  Grisell Ortiz-Lasanta,  Mordechai Rabinovitz,  David Bernstein,  Michael Bennett,  Trevor Hawkins,  Natarajan Ravendhran,  Aasim M. Sheikh,  Peter Varunok,  Kris V. Kowdley,  Delphine Hennicken,  Fiona McPhee,  Khurram Rana,  Eric A. Hughes,  on behalf of the ALLY-3 Study Team , 
  • Pages: 1127-1135
  • First Published: 23 January 2015

Viral Hepatitis

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Prevention of hepatitis C virus infection and spread in human liver chimeric mice by an anti-CD81 monoclonal antibody

Changhua Ji,  Yang Liu,  Chandra Pamulapati,  Sandhya Bohini,  Georg Fertig,  Michael Schraeml,  Werner Rubas,  Michael Brandt,  Stefan Ries,  Han Ma,  Klaus Klumpp, 
  • Pages: 1136-1144
  • First Published: 22 November 2014
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Long-term effect of HCV eradication in patients with mixed cryoglobulinemia: A prospective, controlled, open-label, cohort study

Laura Gragnani,  Elisa Fognani,  Alessia Piluso,  Barbara Boldrini,  Teresa Urraro,  Alessio Fabbrizzi,  Cristina Stasi,  Jessica Ranieri,  Monica Monti,  Umberto Arena,  Claudio Iannacone,  Giacomo Laffi,  Anna Linda Zignego,  for the MaSVE Study Group , 
  • Pages: 1145-1153
  • First Published: 27 November 2014
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Significant reduction in end-stage liver diseases burden through the national viral hepatitis therapy program in Taiwan

Chun-Ju Chiang,  Ya-Wen Yang,  Jin-De Chen,  San-Lin You,  Hwai-I Yang,  Mei-Hsuan Lee,  Mei-Shu Lai,  Chien-Jen Chen, 
  • Pages: 1154-1162
  • First Published: 05 December 2014
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Hepatitis C virus–induced reduction in miR-181a impairs CD4+ T-cell responses through overexpression of DUSP6

Guang Y. Li,  Yun Zhou,  Ruo S. Ying,  Lei Shi,  Yong Q. Cheng,  Jun P. Ren,  Jeddidiah W.D. Griffin,  Zhan S. Jia,  Chuan F. Li,  Jonathan P. Moorman,  Zhi Q. Yao, 
  • Pages: 1163-1173
  • First Published: 05 December 2014
Open Access

Minimum target prices for production of direct-acting antivirals and associated diagnostics to combat hepatitis C virus

Nikolien van de Ven,  Joe Fortunak,  Bryony Simmons,  Nathan Ford,  Graham S. Cooke,  Saye Khoo,  Andrew Hill, 
  • Pages: 1174-1182
  • First Published: 06 December 2014
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Universal infant immunization and occult hepatitis B virus infection in children and adolescents: A population-based study

Hong-Yuan Hsu,  Mei-Hwei Chang,  Yen-Hsuan Ni,  Cheng-Lun Chiang,  Jia-Feng Wu,  Huey-Ling Chen, 
  • Pages: 1183-1191
  • First Published: 11 December 2014
Free Access

Development and validation of a “capture-fusion” model to study drug sensitivity of patient-derived hepatitis C

Morven E. Cunningham,  Alia Javaid,  Jenny Waters,  Joseph Davidson-Wright,  Joshua L.C. Wong,  Meleri Jones,  Graham R. Foster, 
  • Pages: 1192-1204
  • First Published: 20 October 2014

Steatohepatitis/Metabolic Liver Disease

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Moderate to vigorous physical activity volume is an important factor for managing nonalcoholic fatty liver disease: A retrospective study

Sechang Oh,  Takashi Shida,  Kazumasa Yamagishi,  Kiyoji Tanaka,  Rina So,  Takehiko Tsujimoto,  Junichi Shoda, 
  • Pages: 1205-1215
  • First Published: 01 October 2014
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Conjugated bile acid–activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression

Masayuki Nagahashi,  Kazuaki Takabe,  Runping Liu,  Kesong Peng,  Xiang Wang,  Yun Wang,  Nitai C. Hait,  Xuan Wang,  Jeremy C. Allegood,  Akimitsu Yamada,  Tomoyoshi Aoyagi,  Jie Liang,  William M. Pandak,  Sarah Spiegel,  Phillip B. Hylemon,  Huiping Zhou, 
  • Pages: 1216-1226
  • First Published: 01 November 2014
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CIDEC/FSP27 is regulated by peroxisome proliferator-activated receptor alpha and plays a critical role in fasting- and diet-induced hepatosteatosis

Cédric Langhi,  Ángel Baldán, 
  • Pages: 1227-1238
  • First Published: 21 November 2014
Open Access

Ezetimibe for the treatment of nonalcoholic steatohepatitis: Assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial)

Rohit Loomba,  Claude B. Sirlin,  Brandon Ang,  Ricki Bettencourt,  Rashmi Jain,  Joanie Salotti,  Linda Soaft,  Jonathan Hooker,  Yuko Kono,  Archana Bhatt,  Laura Hernandez,  Phirum Nguyen,  Mazen Noureddin,  William Haufe,  Catherine Hooker,  Meng Yin,  Richard Ehman,  Grace Y. Lin,  Mark A. Valasek,  David A. Brenner,  Lisa Richards, for the San Diego Integrated NAFLD Research Consortium (SINC) , 
  • Pages: 1239-1250
  • First Published: 06 December 2014
Free Access

The p.Ser267Phe variant in SLC10A1 is associated with resistance to chronic hepatitis B

Liang Peng,  Qiang Zhao,  Qibin Li,  Miaoxin Li,  Caixia Li,  Tingting Xu,  Xiangyi Jing,  Xiang Zhu,  Ye Wang,  Fucheng Li,  Ruihong Liu,  Cheng Zhong,  Qihao Pan,  Binghui Zeng,  Qijun Liao,  Bin Hu,  Zhao-xia Hu,  Yang-su Huang,  Pak Sham,  Jinsong Liu,  Shuhua Xu,  Jun Wang,  Zhi-liang Gao,  Yiming Wang, 
  • Pages: 1251-1260
  • First Published: 21 November 2014

Hepatobiliary Malignancies

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High liver fibrosis index FIB-4 is highly predictive of hepatocellular carcinoma in chronic hepatitis B carriers

Beomseok Suh,  Sehhoon Park,  Dong Wook Shin,  Jae Moon Yun,  Hyung-Kook Yang,  Su Jong Yu,  Cheong-Il Shin,  Jin-Soo Kim,  Eunmi Ahn,  Hyejin Lee,  Jin Ho Park,  BeLong Cho, 
  • Pages: 1261-1268
  • First Published: 12 December 2014
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Activation of the transforming growth factor-β/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma

Renumathy Dhanasekaran,  Ikuo Nakamura,  Chunling Hu,  Gang Chen,  Abdul M. Oseini,  Elif Sezin Seven,  Alexander G. Miamen,  Catherine D. Moser,  Wei Zhou,  Toin H. van Kuppevelt,  Jan M. van Deursen,  Taofic Mounajjed,  Martin E. Fernandez-Zapico,  Lewis R. Roberts, 
  • Pages: 1269-1283
  • First Published: 12 December 2014
Free Access

Vps4A functions as a tumor suppressor by regulating the secretion and uptake of exosomal microRNAs in human hepatoma cells

Jin-xing Wei,  Li-hong Lv,  Yun-le Wan,  Yang Cao,  Guo-lin Li,  Hao-ming Lin,  Rui Zhou,  Chang-zhen Shang,  Jun Cao,  Hai He,  Qing-fang Han,  Pei-qing Liu,  Gang Zhou,  Jun Min, 
  • Pages: 1284-1294
  • First Published: 12 December 2014

Autoimmune, Cholestatic and Biliary Disease

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Autoimmune hepatitis in a murine autoimmune polyendocrine syndrome type 1 model is directed against multiple autoantigens

Matthias Hardtke-Wolenski,  Richard Taubert,  Fatih Noyan,  Maren Sievers,  Janine Dywicki,  Jerome Schlue,  Christine S. Falk,  Brita Ardesjö Lundgren,  Hamish S. Scott,  Andreas Pich,  Mark S. Anderson,  Michael P. Manns,  Elmar Jaeckel, 
  • Pages: 1295-1305
  • First Published: 05 December 2014

Liver Failure/Cirrhosis/Portal Hypertension

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Dysregulated iron homeostasis is strongly associated with multiorgan failure and early mortality in acute-on-chronic liver failure

Jaswinder Singh Maras,  Rakhi Maiwall,  H.C. Harsha,  Sukanta Das,  Md.Shabir Hussain,  Chandan Kumar,  Chhagan Bihari,  Archana Rastogi,  Manoj Kumar,  Nirupama Trehanpati,  Shvetank Sharma,  Akhilesh Pandey,  Shiv Kumar Sarin, 
  • Pages: 1306-1320
  • First Published: 05 December 2014
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IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections

Mathieu Sertorio,  Xunya Hou,  Rodrigo F. Carmo,  Hélia Dessein,  Sandrine Cabantous,  Mohammed Abdelwahed,  Audrey Romano,  Fernanda Albuquerque,  Luydson Vasconcelos,  Theomira Carmo,  Jun Li,  Arthur Varoquaux,  Violaine Arnaud,  Pablo Oliveira,  Anas Hamdoun,  Hongbin He,  Suzan Adbelmaboud,  Adil Mergani,  Jie Zhou,  Ahmed Monis,  Leila Beltrao Pereira,  Philippe Halfon,  Marc Bourlière,  Raymundo Parana,  Mitermayer dos Reis,  David Gonnelli,  Patricia Moura,  Nasr Eldin Elwali,  Laurent Argiro,  Yuesheng Li,  Alain Dessein, 
  • Pages: 1321-1331
  • First Published: 05 December 2014

Liver Injury/Regeneration

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Treatment of PD-1−/− mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients

Imir G. Metushi,  M. Anthony Hayes,  Jack Uetrecht, 
  • Pages: 1332-1342
  • First Published: 06 October 2014
Free Access

Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice

Yuka Inaba,  Tomoko Furutani,  Kumi Kimura,  Hitoshi Watanabe,  Sanae Haga,  Yoshiaki Kido,  Michihiro Matsumoto,  Yasuhiko Yamamoto,  Kenichi Harada,  Shuichi Kaneko,  Seiichi Oyadomari,  Michitaka Ozaki,  Masato Kasuga,  Hiroshi Inoue, 
  • Pages: 1343-1356
  • First Published: 25 November 2014
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Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice

Igor Maricic,  Huiming Sheng,  Idania Marrero,  Ekihiro Seki,  Tatiana Kisseleva,  Som Chaturvedi,  Natasha Molle,  Stephanie A. Mathews,  Bin Gao,  Vipin Kumar, 
  • Pages: 1357-1369
  • First Published: 05 December 2014

Liver Biology/Pathobiology

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Enhancing the functional maturity of induced pluripotent stem cell–derived human hepatocytes by controlled presentation of cell–cell interactions in vitro

Dustin R. Berger,  Brenton R. Ware,  Matthew D. Davidson,  Samuel R. Allsup,  Salman R. Khetani, 
  • Pages: 1370-1381
  • First Published: 25 November 2014
Free Access

Analysis of aberrant pre-messenger RNA splicing resulting from mutations in ATP8B1 and efficient in vitro rescue by adapted U1 small nuclear RNA

Wendy L. van der Woerd,  Johanna Mulder,  Franco Pagani,  Ulrich Beuers,  Roderick H.J. Houwen,  Stan F.J. van de Graaf, 
  • Pages: 1382-1391
  • First Published: 25 November 2014

Special Article

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Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: Findings and recommendations from an American Association for the Study of Liver Diseases–U.S. Food and Drug Administration Joint Workshop

Arun J. Sanyal,  Scott L. Friedman,  Arthur J. McCullough,  Lara Dimick-Santos, 
  • Pages: 1392-1405
  • First Published: 29 December 2014

New Horizons

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Molecular pathophysiology of portal hypertension

Mercedes Fernandez, 
  • Pages: 1406-1415
  • First Published: 05 August 2014
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Technical standards for hepatitis B virus X protein (HBx) research

Betty L. Slagle,  Ourania M. Andrisani,  Michael J. Bouchard,  Caroline G.L. Lee,  J.-H. James Ou,  Aleem Siddiqui, 
  • Pages: 1416-1424
  • First Published: 07 August 2014

Hepatology Elsewhere

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Is petoxifylline still an option in severe alcoholic hepatitis?

Juan Caballeria M.D., Ph.D., 
  • Pages: 1425-1427
  • First Published: 12 December 2014
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Prometheus and progenitors

Anna Mae Diehl M.D., 
  • Pages: 1427-1429
  • First Published: 24 December 2014

Clinical Observations in Hepatology

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Takotsubo cardiomyopathy following acute liver failure

Loretta L. Jophlin,  David G. Koch, 
  • Pages: 1430-1431
  • First Published: 09 June 2014
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Immunoglobulin G4-related sclerosing cholangitis

Deepak Joshi,  George J. Webster, 
  • Pages: 1432-1434
  • First Published: 01 September 2014

Correspondence

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Primary biliary cirrhosis: Time to replace a misnomer

Giovanni Battista Levi Sandri M.D., 
  • Page: 1435
  • First Published: 06 August 2014
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Reply

Christoph Schramm M.D.,  Inka Wahl Ph.D.,  Ansgar W. Lohse M.D., 
  • Page: 1435
  • First Published: 06 August 2014
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Decreased in vitro anticoagulant potency of Rivaroxaban and Apixaban in plasma from patients with cirrhosis

Wilma Potze B.SC.,  Jelle Adelmeijer B.SC.,  Ton Lisman PH.D., 
  • Pages: 1435-1436
  • First Published: 01 August 2014
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Reply

Melissa Martinez M.D,  Anand Tandra M.D. M.S,  Raj Vuppalanchi M.D, 
  • Pages: 1436-1437
  • First Published: 01 August 2014
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HCV reinfection among HIV-positive men who have sex with men: A pragmatic approach

Thomas C.S. Martin M.R.C.P.,  Gurmit Jagjit Singh M.R.C.P.,  Myra McClure Ph.D.,  Mark Nelson F.R.C.P., 
  • Page: 1437
  • First Published: 22 August 2014
Open Access

Reply

Tamer Abdelrahman M.B.B.Ch., M.Sc.,  Joseph Hughes Ph.D.,  Janice Main F.R.C.P.,  John McLauchlan Ph.D.,  Mark Thursz F.R.C.P., M.D.,  Emma Thomson M.R.C.P., Ph.D., 
  • Page: 1438
  • First Published: 22 August 2014
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Waiting time and transplantation for hepatocellular cancer: A balance between tempus fugit and carpe diem

Quirino Lai M.D.,  Jan Lerut M.D., Ph.D,  For the European Hepatocellular Cancer Liver Transplant (EurHeCaLT) Study Group , 
  • Pages: 1438-1439
  • First Published: 11 September 2014
Free Access

Reply

Karim J. Halazun M.D.,  Abbas A. Rana M.D.,  Rachel E. Patzer Ph.D.,  Benjamin Samstein M.D.,  Robert S. Brown Jr. M.D.,  Jean C. Emond M.D., 
  • Page: 1439
  • First Published: 11 September 2014
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Understanding the pathophysiological regulatory role of microRNAs in acute liver failure

Daniel J. Antoine Ph.D.,  James W. Dear Ph.D.,  Christopher E. Goldring Ph.D.,  B. Kevin Park Ph.D., 
  • Pages: 1439-1440
  • First Published: 01 August 2014
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Reply

Heike Bantel M.D,  Thomas Thum M.D., Ph.D.,  Klaus Schulze-Osthoff Ph.D., 
  • Pages: 1440-1441
  • First Published: 01 August 2014
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Hepatitis E virus seroprevalence in the United States: No easy answers

Mark H. Kuniholm Ph.D.,  Ronald E. Engle B.S., M(ASCP),  Robert H. Purcell M.D.,  Kenrad E. Nelson M.D., 
  • Pages: 1441-1442
  • First Published: 04 July 2014
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Hepatitis E virus seroprevalence in the National Health and Nutrition Examination Survey: Facts trump opinion

Ronald E. Engle B.S., M(ASCP),  Mark H. Kuniholm Ph.D.,  Kenrad E. Nelson M.D.,  Robert H. Purcell M.D., 
  • Page: 1442
  • First Published: 04 July 2014
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Reply

Michael Charlton M.B.B.S., F.R.C.P., 
  • Pages: 1442-1443
  • First Published: 16 January 2015

Obituary

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John L. Gollan, M.D., Ph.D., March 3, 1942-January 6, 2015

Michael F. Sorrell M.D., 
  • Pages: 1444-1445
  • First Published: 18 February 2015

Correction

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Correction

  • Pages: 1446-1447
  • First Published: 10 January 2015

Free Access

Correction

  • Page: 1448
  • First Published: 13 February 2015