A microfluidic lung contains capillary-sized microfluidic structures which resemble computer chips. Its branching pattern somewhat resembles the branching pattern of real lung's vessels and bronchial tree. We thought it best to illustrate the artificial lung metaphorically, with the microfluidic structures in place of the natural structures. The final result is half natural, half mechanical.

In 1985, Dr. Semb implanted the first total artificial heart in Europe.

Overview of interventions to improve outcomes for those on ECLS.

Twenty-eight observational studies reporting on the use of extracorporeal life support (ECLS) for coronavirus disease 2019 (COVID-19) have been identified. Veno-venous (V-V) ECLS was the most used support. However, veno-arterial (V-A) ECLS, Impella, or hybrid ECLS configurations were reported only in 7.3% of cases, despite a high incidence of cardio-circulatory complications, cardiac deaths. ECLS configuration change to provide adequate mechanical circulatory support (MCS) was required in 3.1% of ECLS patients. Thus, MCS might have been under-used in COVID-19 patients, and further studies are warranted to establish the correct indications and timing for MCS in COVID-19.

An acellular, natural, three-dimensional biological decellularized hypopharynx with vascular pedicle scaffold as the substitute materials for hypopharyngeal reconstruction could be prepared by perfusing 1% SDS and triton X-100. This composite decellularized scaffold preserved the structure and components of the natural extracellular matrix and have little immunogenicity.

The decellularization process of a porcine pulmonary artery (PA) wall using detergents sodium dodecyl sulfate (SDS) and sodium deoxycholate is effective. The ethanol-washing method for SDS-based decellularization of the porcine PA wall can reduce the residual cytotoxic SDS content and preserve extracellular matrix structures, especially in elastic fibers; thus, it can enhance cell repopulation after implantation.

A tubular pulsatile pump was experimentally characterized in a simulated failing left ventricle. The effect of pulsation timing on flow and pressure was quantified. The proposed design provides adequate output for mechanical circulatory support, while minimizing the number of moving parts that could otherwise lead to tribological wear.

This study employs rigorous computational techniques to assess the risk of post-TAVR cardiac conduction abnormality in patient-specific anatomy. Among various factors analyzed in this study, area-weighted average of the maximum principal logarithmic strain exerted by the TAVR prosthesis in the membranous septum region during the device deployment was found to be a strong predictor for assessing CCA risk associated with TAVR devices. Such patient specific studies could further be used for preprocedural planning in order to minimize the CCA risk.

HeartCon Magnetic and Hydrodynamic Levitation Blood Pump (RocketHeart, Tianjin, China) was used in the construction of CF-LVAD assisted animal models. With CF-LVAD support, the risk of aortic valve closure can be predicted by the combined application of pump speed, left ventricular systolic pressure, artificial vascular blood flow, mean arterial pressure and pulse pressure. The model exhibited good differentiation.

Donation after circulatory death (DCD) hearts requires machine perfusion preservation, but the conditions are not empirically defined. DCD rat hearts, or control hearts, were procured and perfused for 60 min with one of three machine perfusions solutions (MPS)—St. Thomas (ST), University of Wisconsin (UW), or Polyethylene Glycol-20k (PEG)—at one of two temperatures—4°C or 15°C. Compared to the other solutions and temperature, perfusion preservation with PEG MPS at 15°C, displayed a homogeneous tissue perfusion and reduced cardiac damage.

This study proposed a risk classification model for successful Impella weaning. Hemodynamic assessment using pulmonary artery catheter allowed us to clearly stratify the risk of 30-day mortality or reintroduction of mechanical circulatory support after Impella weaning.

In more than 10,000 ECMO runs, ELSO Registry data show ECMO mostly managed in CTICU settings; however, the majority of ECMO is not related to a cardiac surgery procedure. After adjustment, statistically significant but clinically minor on-ECMO management and physiologic metrics were observed across ICU types.

• The success rate of haemostasis using arteriotomy wound closure during VA-ECMO decannulation was similar between ProGlide and Manta.
• The complications of percutaneous closure by the two devices were low.

We retrospectively investigated 220 patients undergoing HVAD-implantation between July´2009 and March´2019 atour institution. Infections and thrombotic eventswere more common on long-term supported patients. Those with higher CRP levels during the infection were more likely to have ischaemic stroke(IS), though not PT. In multivariate analysis there was no significant effect of infection determining thrombotic events. In summary, both thrombotic events and infections were related to the duration of support. However, Infections do not clearly predispose to thrombosis events.

Reported use of preventive methods between centers with high and low prevalence of HeartMate 3 driveline infection.

Septic patients combined with acute kidney injury exhibited decreased Th1 percentages and Th1/Th2 ratios, and increased Th2, Th17 and T_reg percentages and Th17/T_reg ratios; early high-dose continuous venous-venous hemofiltration (CVVH) alleviated these alterations. Th1 percentages and Th1/Th2 ratios were negatively correlated with sequential organ failure assessment (SOFA) scores, while Th2, Th17 and T_reg percentages and Th17/T_reg ratios were positively correlated with SOFA scores. Patients with CVVH had significantly lower SOFA scores and a shorter ICU stay.

Aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) as well De Ritis adjusted AST (DRA) are significantly associated with pump thrombosis (p < 0.0001 for each). DRA is a potential screening biomarker for hemolysis and device thrombosis in stable left ventricular assist device patients.

LVAD percutaneous decommissioning steps are easy and reproducible. Besides, the results concluded its safety and efficacy.

Clinical pathway of an intracardiac hematoma treated by ECMO support.

A variety of microfabrication technologies are currently utilized for several tissue engineering applications, such as soft lithography, microneedles, templated and self-assembly of microstructures, microfluidics, fiber spinning, and bioprinting. These microfabrication technologies have been implemented to construct close-to-native three-dimensional structures at numerous physiological scales, which are essential to confer the functional characteristics of living tissues. This review covers some of the most exciting research contributions from in vitro tissue engineering research to potential applications in regenerative medicine.