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    Aging Cell: Volume 18, Issue 2

    April 2019
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ISSUE INFORMATION

Free Access

Issue Information

  • First Published: 12 March 2019

REVIEW

Open Access

Age-dependent changes and biomarkers of aging in Caenorhabditis elegans

Heehwa G. Son,  Ozlem Altintas,  Eun Ji E. Kim,  Sujeong Kwon,  Seung-Jae V. Lee, 
  • First Published: 08 February 2019

ORIGINAL PAPERS

Open Access

Knockout of receptor for advanced glycation end-products attenuates age-related renal lesions

Thibault Teissier,  Valentine Quersin,  Viviane Gnemmi,  Maité Daroux,  Mike Howsam,  Florian Delguste,  Cécile Lemoine,  Chantal Fradin,  Ann-Marie Schmidt,  Christelle Cauffiez,  Thierry Brousseau,  François Glowacki,  Frédéric J. Tessier,  Eric Boulanger,  Marie Frimat, 
  • First Published: 22 February 2019
Open Access

Hypothalamic gene transfer of BDNF promotes healthy aging in mice

Travis McMurphy,  Wei Huang,  Xianglan Liu,  Jason J. Siu,  Nicholas J. Queen,  Run Xiao,  Lei Cao, 
  • First Published: 26 December 2018

ORIGINAL ARTICLE

Open Access

The TrkB-T1 receptor mediates BDNF-induced migration of aged cardiac microvascular endothelial cells by recruiting Willin

Zhefeng Wang,  Yilin Chen,  Xuwei Chen,  Xin Zheng,  Ganlin Xu,  Ziqiang Yuan,  Hui Zhao,  Wensheng Chen,  Lilin Li,  Nianjue Zheng,  Xiaotao Shen,  Yanmei Li,  Xufeng Qi,  Dongqing Cai, 
  • First Published: 22 January 2019

ORIGINAL PAPER

Open Access

Acarbose improves health and lifespan in aging HET3 mice

David E. Harrison,  Randy Strong,  Silvestre Alavez,  Clinton Michael Astle,  John DiGiovanni,  Elizabeth Fernandez,  Kevin Flurkey,  Michael Garratt,  Jonathan A. L. Gelfond,  Martin A. Javors,  Moshe Levi,  Gordon J. Lithgow,  Francesca Macchiarini,  James F. Nelson,  Stacey J. Sukoff Rizzo,  Thomas J. Slaga,  Tim Stearns,  John Erby Wilkinson,  Richard A. Miller, 
  • First Published: 27 January 2019

ORIGINAL ARTICLES

Open Access

Alogliptin improves survival and health of mice on a high-fat diet

Biao Zhu,  Yixiang Li,  Lingwei Xiang,  Jiajia Zhang,  Li Wang,  Bei Guo,  Minglu Liang,  Long Chen,  Lin Xiang,  Jing Dong,  Min Liu,  Wen Mei,  Huan Li,  Guangda Xiang, 
  • First Published: 15 January 2019
Open Access

Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF-16 in C. elegans

Aiping Xu,  Zhao Zhang,  Su-Hyuk Ko,  Alfred L. Fisher,  Zhijie Liu,  Lizhen Chen, 
  • First Published: 14 January 2019

ORIGINAL PAPERS

Open Access

Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells

Arne Søraas,  Mieko Matsuyama,  Marcos de Lima,  David Wald,  Jochen Buechner,  Tobias Gedde-Dahl,  Camilla Lund Søraas,  Brian Chen,  Luigi Ferrucci,  John Arne Dahl,  Steve Horvath,  Shigemi Matsuyama, 
  • First Published: 02 February 2019
Open Access

Dietary restriction and gonadal signaling differentially regulate post-development quality control functions in Caenorhabditis elegans

Nufar Shpigel,  Netta Shemesh,  Mor Kishner,  Anat Ben-Zvi, 
  • First Published: 15 January 2019
Open Access

Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging

Eunhui Seo,  Hwansu Kang,  Hojung Choi,  Woohyuk Choi,  Hee-Sook Jun, 
  • First Published: 04 January 2019
Open Access

Circumventing senescence is associated with stem cell properties and metformin sensitivity

Xavier Deschênes-Simard,  Maxime Parisotto,  Marie-Camille Rowell,  Benjamin Le Calvé,  Sebastian Igelmann,  Karine Moineau-Vallée,  Emmanuelle Saint-Germain,  Paloma Kalegari,  Véronique Bourdeau,  Filippos Kottakis,  Nabeel Bardeesy,  Gerardo Ferbeyre, 
  • First Published: 06 January 2019
Open Access

Hyperoxygenation revitalizes Alzheimer’s disease pathology through the upregulation of neurotrophic factors

Juli Choi,  Hye-Jin Kwon,  Jung-Eun Lee,  Yunjin Lee,  Ju-Young Seoh,  Pyung-Lim Han, 
  • First Published: 11 February 2019
Open Access

Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation

Yuk Yuen Lan,  James M. Heather,  Thomas Eisenhaure,  Christopher Stuart Garris,  David Lieb,  Raktima Raychowdhury,  Nir Hacohen, 
  • First Published: 31 January 2019
Open Access

The mir-465 family is upregulated with age and attenuates growth hormone signaling in mouse liver

Amy E. Elias,  Bianca Kun,  Ian M. C. Sabula,  Gail Golomb-Mello,  Andrea Cespedes Zablah,  Jill A. Kreiling, 
  • First Published: 13 January 2019

ORIGINAL ARTICLE

Open Access

Long-term intake of phenolic compounds attenuates age-related cardiac remodeling

Stéphanie Chacar,  Joelle Hajal,  Youakim Saliba,  Patrick Bois,  Nicolas Louka,  Richard G. Maroun,  Jean-François Faivre,  Nassim Fares, 
  • First Published: 24 January 2019

ORIGINAL PAPERS

Open Access

Sirt1–hypoxia-inducible factor-1α interaction is a key mediator of tubulointerstitial damage in the aged kidney

Dong Ryeol Ryu,  Mi Ra Yu,  Kyoung Hye Kong,  Hyoungnae Kim,  Soon Hyo Kwon,  Jin Seok Jeon,  Dong Cheol Han,  Hyunjin Noh, 
  • First Published: 06 January 2019
Open Access

Inhibition of nucleolar stress response by Sirt1: A potential mechanism of acetylation-independent regulation of p53 accumulation

Xiaolei Bi,  Qing Ye,  Daoyuan Li,  Qisheng Peng,  Zhe Wang,  Xiao Wu,  Yun Zhang,  Qunye Zhang,  Fan Jiang, 
  • First Published: 08 January 2019

ORIGINAL ARTICLE

Open Access

Activation of MT2 receptor ameliorates dendritic abnormalities in Alzheimer’s disease via C/EBPα/miR-125b pathway

Hui Tang,  Mei Ma,  Ying Wu,  Man-Fei Deng,  Fan Hu,  Hasan.a.m.m. Almansoub,  He-Zhou Huang,  Ding-Qi Wang,  Lan-Ting Zhou,  Na Wei,  Hengye Man,  Youming Lu,  Dan Liu,  Ling-Qiang Zhu, 
  • First Published: 01 February 2019

ORIGINAL PAPERS

Open Access

17-α estradiol ameliorates age-associated sarcopenia and improves late-life physical function in male mice but not in females or castrated males

Michael Garratt,  Danielle Leander,  Kaitlyn Pifer,  Brian Bower,  Jonathan J. Herrera,  Sharlene M. Day,  Oliver Fiehn,  Susan V. Brooks,  Richard A. Miller, 
  • First Published: 10 February 2019
Open Access

Low plasma lysophosphatidylcholines are associated with impaired mitochondrial oxidative capacity in adults in the Baltimore Longitudinal Study of Aging

Richard D. Semba,  Pingbo Zhang,  Fatemeh Adelnia,  Kai Sun,  Marta Gonzalez-Freire,  Norman Salem Jr,  Nicholas Brennan,  Richard G. Spencer,  Kenneth Fishbein,  Mohammed Khadeer,  Michelle Shardell,  Ruin Moaddel,  Luigi Ferrucci, 
  • First Published: 04 February 2019

ORIGINAL ARTICLE

Open Access

Conservation of physiological dysregulation signatures of aging across primates

Gabriel Dansereau,  Tina W. Wey,  Véronique Legault,  Marie A. Brunet,  Joseph W. Kemnitz,  Luigi Ferrucci,  Alan A. Cohen, 
  • First Published: 11 February 2019

ORIGINAL PAPER

Open Access

HIF1α-mediated AIMP3 suppression delays stem cell aging via the induction of autophagy

Chul Kim,  Ji-Min Park,  Youngsook Song,  Sunghoon Kim,  Jisook Moon, 
  • First Published: 31 January 2019

SHORT TAKE

Open Access

Influenza virus inoculum volume is critical to elucidate age-dependent mortality in mice

Candice A. Smith,  Upasana Kulkarni,  Judy Chen,  Daniel R. Goldstein, 
  • First Published: 11 January 2019
Open Access

sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice

Chang Hoon Cho,  Ki Hyun Yoo,  Alfredo Oliveros,  Summer Paulson,  Syed Mohammed Qasim Hussaini,  Jan M. van Deursen,  Mi-Hyeon Jang, 
  • First Published: 04 January 2019
Open Access

Identification of stable senescence-associated reference genes

Alejandra Hernandez-Segura,  Richard Rubingh,  Marco Demaria, 
  • First Published: 01 February 2019

CORRIGENDUM

Open Access

Corrigendum

  • First Published: 12 March 2019

Open Access

Corrigendum

  • First Published: 12 March 2019