• Issue

    Aging Cell: Volume 13, Issue 3

    i-iii, 391-578
    June 2014
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Issue Information

Free Access

Issue Information

  • Pages: i-iii
  • First Published: 23 May 2014

Review

Open Access

Optimal body weight for health and longevity: bridging basic, clinical, and population research

Luigi Fontana,  Frank B. Hu, 
  • Pages: 391-400
  • First Published: 14 March 2014

Original Articles

Open Access

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

Nicola Raule,  Federica Sevini,  Shengting Li,  Annalaura Barbieri,  Federica Tallaro,  Laura Lomartire,  Dario Vianello,  Alberto Montesanto,  Jukka S. Moilanen,  Vladyslav Bezrukov,  Hélène Blanché,  Antti Hervonen,  Kaare Christensen,  Luca Deiana,  Efstathios S. Gonos,  Tom B. L. Kirkwood,  Peter Kristensen,  Alberta Leon,  Pier Giuseppe Pelicci,  Michel Poulain,  Irene M. Rea,  Josè Remacle,  Jean Marie Robine,  Stefan Schreiber,  Ewa Sikora,  Peternella Eline Slagboom,  Liana Spazzafumo,  Maria Antonietta Stazi,  Olivier Toussaint,  James W. Vaupel,  Giuseppina Rose,  Kari Majamaa,  Markus Perola,  Thomas E. Johnson,  Lars Bolund,  Huanming Yang,  Giuseppe Passarino,  Claudio Franceschi, 
  • Pages: 401-407
  • First Published: 17 December 2013

Open Access

Reductions in serum IGF-1 during aging impair health span

Zhenwei Gong,  Oran Kennedy,  Hui Sun,  YingJie Wu,  Garry A Williams,  Laura Klein,  Luis Cardoso,  Ronald W. Matheny Jr,  Gene B. Hubbard,  Yuji Ikeno,  Roger P. Farrar,  Mitchell B Schaffler,  Martin L Adamo,  Radhika H Muzumdar,  Shoshana Yakar, 
  • Pages: 408-418
  • First Published: 17 December 2013
Open Access

Integrin-linked kinase modulates longevity and thermotolerance in C. elegans through neuronal control of HSF-1

Caroline Kumsta,  Tsui-Ting Ching,  Mayuko Nishimura,  Andrew E. Davis,  Sara Gelino,  Hannah H. Catan,  Xiaokun Yu,  Chu-Chiao Chu,  Binnan Ong,  Siler H. Panowski,  Nathan Baird,  Rolf Bodmer,  Ao-Lin Hsu,  Malene Hansen, 
  • Pages: 419-430
  • First Published: 06 December 2013
Open Access

A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging

Mayuko Nishimura,  Caroline Kumsta,  Gaurav Kaushik,  Soda B. Diop,  Yun Ding,  Jumana Bisharat-Kernizan,  Hannah Catan,  Anthony Cammarato,  Robert S. Ross,  Adam J. Engler,  Rolf Bodmer,  Malene Hansen,  Karen Ocorr, 
  • Pages: 431-440
  • First Published: 09 January 2014
Open Access

Aging is associated with increased regulatory T-cell function

Sanjay K. Garg,  Colin Delaney,  Tomomi Toubai,  Amiya Ghosh,  Pavan Reddy,  Ruma Banerjee,  Raymond Yung, 
  • Pages: 441-448
  • First Published: 10 December 2013
Open Access

P44, the ‘longevity-assurance’ isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion

Mariana Pehar,  Mi Hee Ko,  Mi Li,  Heidi Scrable,  Luigi Puglielli, 
  • Pages: 449-456
  • First Published: 17 December 2013
Open Access

Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity

Jia Hu,  Min Wei,  Hamed Mirzaei,  Federica Madia,  Mario Mirisola,  Camille Amparo,  Shawna Chagoury,  Brian Kennedy,  Valter D. Longo, 
  • Pages: 457-467
  • First Published: 20 March 2014
Open Access

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Richard A. Miller,  David E. Harrison,  Clinton M. Astle,  Elizabeth Fernandez,  Kevin Flurkey,  Melissa Han,  Martin A. Javors,  Xinna Li,  Nancy L. Nadon,  James F. Nelson,  Scott Pletcher,  Adam B. Salmon,  Zelton Dave Sharp,  Sabrina Van Roekel,  Lynn Winkleman,  Randy Strong, 
  • Pages: 468-477
  • First Published: 17 December 2013
Open Access

Smurf2 regulates hematopoietic stem cell self-renewal and aging

Charusheila Ramkumar,  Yahui Kong,  Sally E. Trabucco,  Rachel M. Gerstein,  Hong Zhang, 
  • Pages: 478-486
  • First Published: 04 February 2014
Open Access

Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis

Jelena Vjetrovic,  Pattabhiraman Shankaranarayanan,  Marco A. Mendoza-Parra,  Hinrich Gronemeyer, 
  • Pages: 487-496
  • First Published: 04 March 2014
Open Access

The contribution of visceral fat to improved insulin signaling in Ames dwarf mice

Vinal Menon,  Xu Zhi,  Tanvir Hossain,  Andrzej Bartke,  Adam Spong,  Adam Gesing,  Michal M. Masternak, 
  • Pages: 497-506
  • First Published: 12 February 2014
Open Access

Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Aβ42-induced neurodegeneration

Ran Lin,  Alessia Angelin,  Federico Da Settimo,  Claudia Martini,  Sabrina Taliani,  Shigong Zhu,  Douglas C. Wallace, 
  • Pages: 507-518
  • First Published: 21 February 2014
Open Access

Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation

Airi Jo-Watanabe,  Takamoto Ohse,  Hiroaki Nishimatsu,  Masao Takahashi,  Yoichiro Ikeda,  Takehiko Wada,  Jun-ichi Shirakawa,  Ryoji Nagai,  Toshio Miyata,  Tetsuo Nagano,  Yasunobu Hirata,  Reiko Inagi,  Masaomi Nangaku, 
  • Pages: 519-528
  • First Published: 24 February 2014
Open Access

Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart

Dao-Fu Dai,  Pabalu P. Karunadharma,  Ying A. Chiao,  Nathan Basisty,  David Crispin,  Edward J. Hsieh,  Tony Chen,  Haiwei Gu,  Danijel Djukovic,  Daniel Raftery,  Richard P. Beyer,  Michael J. MacCoss,  Peter S. Rabinovitch, 
  • Pages: 529-539
  • First Published: 25 February 2014
Open Access

Induction of oxidative stress causes functional alterations in mouse urothelium via a TRPM8-mediated mechanism: implications for aging

Linda Nocchi,  Donna M. Daly,  Christopher Chapple,  David Grundy, 
  • Pages: 540-550
  • First Published: 05 March 2014
Open Access

Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity

Alexia Gómez,  Ines Sánchez-Roman,  Jose Gomez,  Julia Cruces,  Ianire Mate,  Mónica Lopez-Torres,  Alba Naudi,  Manuel Portero-Otin,  Reinald Pamplona,  Monica De la Fuente,  Gustavo Barja, 
  • Pages: 551-560
  • First Published: 26 February 2014
Open Access

Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine

Paola Gamba,  Michela Guglielmotto,  Gabriella Testa,  Debora Monteleone,  Chiara Zerbinati,  Simona Gargiulo,  Fiorella Biasi,  Luigi Iuliano,  Giorgio Giaccone,  Alessandro Mauro,  Giuseppe Poli,  Elena Tamagno,  Gabriella Leonarduzzi, 
  • Pages: 561-572
  • First Published: 25 February 2014

Short Takes

Open Access

Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN-deficient human fibroblasts

Bidisha Saha,  Alexander Cypro,  George M. Martin,  Junko Oshima, 
  • Pages: 573-575
  • First Published: 06 December 2013
Open Access

Superoxide signaling in perivascular adipose tissue promotes age-related artery stiffness

Bradley S. Fleenor,  Jason S. Eng,  Amy L. Sindler,  Bryant T. Pham,  Jackson D. Kloor,  Douglas R. Seals, 
  • Pages: 576-578
  • First Published: 17 December 2013