• Issue

    Fundamental & Clinical Pharmacology: Volume 38, Issue 1

    1-204
    February 2024
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ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 1-3
  • First Published: 25 January 2024

REVIEW ARTICLES

Ephrin B/EphB in neuropathic pain: Role and molecular mechanisms

Sahibpreet Kaur,  Anjana Bali,  Nirmal Singh,  Amteshwar Singh Jaggi, 
  • Pages: 4-12
  • First Published: 03 July 2023

Human neutrophil elastase inhibitors: Classification, biological-synthetic sources and their relevance in related diseases

Jhonnatan Styver Ocampo-Gallego,  David Pedroza-Escobar,  Ana Ruth Caicedo-Ortega,  María Teresa Berumen-Murra,  Ana Lucía Novelo-Aguirre,  Rebeca Denis de Sotelo-León,  Dealmy Delgadillo-Guzmán, 
  • Pages: 13-32
  • First Published: 23 August 2023

Can cannabidiol have an analgesic effect?

Bartłomiej Kulesza,  Marek Mazurek,  Jacek Kurzepa, 
  • Pages: 33-41
  • First Published: 16 August 2023

Changes in serotonin neurotransmission as assayed by microdialysis after acute, intermittent or chronic ethanol administration and withdrawal

Abdelkader Dahchour,  Roberta J. Ward, 
  • Pages: 42-59
  • First Published: 15 September 2023

ORIGINAL ARTICLES

FUNDAMENTAL PHARMACOLOGY

ANTIMICROBIAL, ANTIVIRAL AGENTS

Synthesis, spectroscopic characterization, and antibacterial activity of chalcone (2E)-1-(3′-aminophenyl)-3-(4-dimethylaminophenyl)-prop-2-en-1-one against multiresistant Staphylococcus aureus carrier of efflux pump mechanisms and β-lactamase

Larissa da Silva,  Isydório Alves Donato,  Suieny Rodrigues Bezerra,  Hélcio Silva dos Santos,  Paulo Nogueira Bandeira,  Maria Thalia Ramos do Nascimento,  Jesyka Macêdo Guedes,  Priscila Ramos Freitas,  Ana Carolina Justino de Araújo,  Thiago Sampaio de Freitas,  Henrique Douglas Melo Coutinho,  Yedda Maria Lobo Soares de Matos,  Lígia Cláudia Castro de Oliveira,  Francisco Assis Bezerra da Cunha, 
  • Pages: 60-71
  • First Published: 27 July 2023
Open Access

In vitro anti-trypanosomal activity of synthetic nitrofurantoin-triazole hybrids against Trypanosoma species causing human African trypanosomosis

Anna Seetsi,  David D. N'da,  Nthatisi Molefe-Nyembe,  Keisuke Suganuma,  Tsepo Ramatla,  Oriel Thekisoe, 
  • Pages: 72-83
  • First Published: 21 July 2023

Potentiating-antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi-drug resistant (MDR) strains

Ana Carolina Justino de Araújo,  Priscilla Ramos Freitas,  Isaac Moura Araújo,  Gustavo Miguel Siqueira,  João Arthur de Oliveira Borges,  Daniel Sampaio Alves,  Gustavo Marinho Miranda,  Igor José dos Santos Nascimento,  João Xavier de Araújo-Júnior,  Edeildo Ferreira da Silva-Júnior,  Thiago Mendonça de Aquino,  Francisco Jaime Bezerra Mendonça Junior,  Emmanuel Silva Marinho,  Helcio Silva dos Santos,  Saulo Relison Tintino,  Henrique Douglas Melo Coutinho, 
  • Pages: 84-98
  • First Published: 30 August 2023

ONCOPHARMACOLOGYS

Dose-dependent bidirectional pharmacological effects of vinorelbine-based metronomic combination chemotherapy on tumor growth and metastasis and mechanisms in melanoma mouse model

Hua Liu,  Qiaowei Zheng,  Min Li,  Jianrong Kou,  Junsong Wei,  Weiyi Feng, 
  • Pages: 99-112
  • First Published: 17 July 2023

Dihydroartemisinin inhibits angiogenesis in breast cancer via regulating VEGF and MMP-2/-9

Qi Rao,  He Yu,  Ruochan Li,  Bin He,  Yuxue Wang,  Xiaohong Guo,  Gang Zhao,  Fenghua Wu, 
  • Pages: 113-125
  • First Published: 25 July 2023

Role of apoptosis and autophagy in folic acid-induced cytotoxicity of human breast cancer cells in vitro

Munevver Baran,  Gozde Ozge Onder,  Ozge Goktepe,  Arzu Yay, 
  • Pages: 126-138
  • First Published: 16 August 2023

NEUROPHARMACOLOGYS

Preliminary evaluation of the efficacy and safety of brimonidine for deep sedation

Xiaohui Wang,  Rui Zhang,  Bin Chen,  Ting Zhang,  Xinghua Jin,  Ping Gao, 
  • Pages: 139-151
  • First Published: 23 August 2023

TOXICOPHARMACOLOGYS

Open Access

Busulfan induces steatosis in HepaRG cells but not in primary human hepatocytes: Possible explanations and implication for the prediction of drug-induced liver injury

Julien Allard,  Simon Bucher,  Pierre-Jean Ferron,  Youenn Launay,  Bernard Fromenty, 
  • Pages: 152-167
  • First Published: 04 September 2023

INFLAMMATION, IMMUNOPHARMACOLOGYS

Evaluation of the anti-inflammatory effect of 1,4-dihydropyridine derivatives

Bruno Matheus Facchin,  Tainá Larissa Lubschinski,  Yeo Jim Kinoshita Moon,  Paula Giarola Fragoso de Oliveira,  Bianca Klafke Beck,  Ziliani da Silva Buss,  Luiz Antonio Escorteganha Pollo,  Maique Weber Biavatti,  Louis Pergaud Sandjo,  Eduardo Monguilhott Dalmarco, 
  • Pages: 168-182
  • First Published: 09 August 2023

CLINICAL PHARMACOLOGY

Open Access

Paclitaxel alters melanogenesis and causes pigmentation in the skin of gynecological cancer patients

Paula Montero,  Celia Sanz,  Jose Alejandro Pérez-Fidalgo,  Martín Pérez-Leal,  Javier Milara,  Julio Cortijo, 
  • Pages: 183-191
  • First Published: 23 July 2023

Vestibular disorders following BNT162b2 mRNA COVID-19 vaccination: A retrospective case series

Helmi Ammar,  Christine Le Beller,  Didier Bouccara,  David Malinvaud,  Romain Jouffroy,  Agnès Lillo-Le Louet, 
  • Pages: 192-204
  • First Published: 20 July 2023