• Issue

    Respirology: Volume 23, Issue 11

    961-1077
    November 2018

ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 961-965
  • First Published: 14 October 2018

ORIGINAL ARTICLES

COPD

Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD

  • Pages: 1023-1031
  • First Published: 26 April 2018
Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD

Blood eosinophils, in contrast to neutrophils, reflect eosinophils in sputum, biopsies and bronchoalveolar lavage (BAL), in inhaled corticosteroids (ICS)-naïve COPD patients. However, both baseline eosinophils and neutrophils, whether measured in blood, sputum, biopsies and BAL, insufficiently predict lung function response to ICS in COPD over a period of 6–30 months.

See relatedEditorial

Interstitial Lung Disease

Prognostic factors and disease behaviour of pathologically proven fibrotic non-specific interstitial pneumonia

  • Pages: 1032-1040
  • First Published: 24 April 2018

Non-specific interstitial pneumonia (NSIP) has heterogeneous characteristics in terms of background, disease behaviour and prognosis. Some patients with idiopathic fibrotic NSIP with or without interstitial pneumonia with autoimmune features (IPAF) showed progressive disease despite therapy.

Multidimensional improvement in connective tissue disease-associated interstitial lung disease: Two courses of pulse dose methylprednisolone followed by low-dose prednisone and tacrolimus

  • Pages: 1041-1048
  • First Published: 16 July 2018
Multidimensional improvement in connective tissue disease-associated interstitial lung disease: Two courses of pulse dose methylprednisolone followed by low-dose prednisone and tacrolimus

Two courses of pulse dose methylprednisolone therapy followed by 1 year of tacrolimus combination therapy with corticosteroids was well tolerated and improved not only lung physiology but also exercise capacity, exercise oxygen desaturation and patient-reported outcomes (PRO) such as dyspnoea and health-related quality of life (HRQoL).

See relatedEditorial

Lung cancer

Virtual bronchoscopic navigation as an aid to CT-guided transbronchial biopsy improves the diagnostic yield for small peripheral pulmonary lesions

  • Pages: 1049-1054
  • First Published: 07 August 2018

Computed tomography (CT)-guided transbronchial biopsy (CT-TBB) is one of the several procedures used to diagnose small peripheral pulmonary lesions (PPL), although its diagnostic yield is unsatisfying. We now report that a combined approach in which virtual bronchoscopic navigation (VBN) is used to assist CT-TBB improves the diagnostic yield for small PPL.

See relatedEditorial

Sleep and Ventilation

Continuous positive airway pressure for obstructive sleep apnoea does not improve asthma control

  • Pages: 1055-1062
  • First Published: 10 July 2018

In this randomized controlled trial involving patients with nocturnal asthma and snoring despite taking moderate-to-high-dose inhaled corticosteroid and long-acting bronchodilators, continuous positive airway pressure (CPAP) therapy for 3 months did not improve asthma control but led to better asthma-related quality of life and vitality than those on conservative treatment.

See relatedEditorial

Tuberculosis

Metformin is associated with a lower risk of active tuberculosis in patients with type 2 diabetes

  • Pages: 1063-1073
  • First Published: 25 June 2018

This retrospective, propensity score-matched cohort study demonstrated that the risk of active tuberculosis (TB) is higher in the type 2 diabetes mellitus population. However, the use of metformin is associated with a decreased risk of active TB in this population.

See relatedEditorial

LETTER FROM ASIA-PACIFIC REGION