Avoiding foods or restricting intake can be a normative approach to manage symptoms of gastroparesis/functional dyspepsia. However, a subset of patients may have an underlying feeding/eating disorder, or be at risk for developing one. This study showed clinically significant feeding/eating disorder symptoms, particularly symptoms of avoidant/restrictive food intake disorder (ARFID), were common among outpatients presenting for gastroparesis/dyspepsia. ARFID is a feeding/eating disorder characterized by avoidant/restrictive eating not motivated by body shape/weight concerns that leads to medical and/or psychosocial consequences. Although multiple etiologic pathways are possible and require further research, clinicians may consider assessing for avoidant/restrictive eating to inform treatment recommendations.

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The unbiased diagnosis of carbohydrate intolerance requires a valid recording of carbohydrate induced symptoms. The paediatric Carbohydrate Perception Questionnaire overcomes the current lack of standardized and validated symptom assessment during carbohydrate breath tests, minimizes bias and can be the basis to standardize the assessment of carbohydrate intolerance.

When interpreting the timed barium swallow image, the surface area of the residual column better reflects the adequacy of esophageal emptying compared to the column height.

Mutation in MRVI1 associated with isolated familial achalasia caused by disturbed cGMP signaling pathway.

Assessed with the 3D-Transit system (C), patients with diabetes had prolonged colonic transit time characterized by more retrograde movements and stasis in the cecum (A). The XY plot (B) shows the median segmental colonic transit times in the cecal and ascending colon (Asc), the transversal colon (Tra), the descending colon (Dsc) and the rectosigmoid colon (Sig) in patients with diabetes and gastrointestinal symptoms (DM) and healthy controls (HC). Whiskers marks interquartile range.

Variability in expert clinicians practices on use of motility investigations in diagnosing CIPO and ED.

A patient per patient comparison of MNBI (mean nocturnal baseline impedance) data in NERD patients with or without biliary reflux. Those with biliary reflux showed lower values.

GI symptoms in joint hypermobility-related disorders.

The straight leg raise (SLR) maneuver during high resolution manometry (HRM) increases intra-abdominal pressure that may transmit into the intra-esophageal cavity when the esophagogastric junction is disrupted. Analysis of intra-esophageal pressure gradients during the maneuver may provide adjunctive evidence supporting GERD.

High resolution manometry (HRM) features of paraesophageal hernia (PEH) were compared to axial hiatus hernias and normal controls, with findings of increased intraluminal intrabolus pressure in the distal esophagus and intragastric pressure with PEH, in addition to short esophageal length. These findings help raise suspicion for the presence of PEH on HRM studies

Chemosensors in the mouse stomach. Most chemosensors had higher expression in the antrum versus corpus, except for CD36, GNAT2, ghrelin, and GOAT. Chemosensors for fatty acids (FFAR4, CD36), protein (GPR93) and the sweet and umami taste receptor subunit (T1R3) were co-expressed with ghrelin.

Chronic stress increases levels of pro-inflammatory cytokines, decreases GR transcriptional binding at epithelia cell tight junction gene promoters reducing tight junction gene expression, culminating in increased paracellular permeability and enhanced visceral pain sensation. Methylation of the repressive histone H3K9me2/me3 plays a central role in this process.

Multiple mouse models of early postnatal malnutrition exhibit slow small bowel progression of FITC-dextran, delayed gastric emptying, and abnormal gross appearance of the stomach. Altered duodenal contractility and permeability are specific to malnourished males.

This is the first study to show that the gene advillin is expressed in a specific population of enteric neurons known as intrinsic primary afferent neurons (IPANs), which uniquely endow the digestive system with intrinsic neural reflex activity. The identity of advillin as a marker for IPANs is supported by morphological, neurochemical, and physiological evidence.