Our study suggests that Id-1 promotes cervical epithelial transformation, which sheds lights on cervical cancer development and implies Id-1 as a potential target for cervical cancer prevention and therapy.

Mitochondrial proteins (ROS) are mediating the apoptotic process, downstream or in parallel, CHOP might be a crucial player for DR5 upregulation and cancer cell killing by quercetin. IRE1a-JNK signaling could also be considered to be the major ER-stress pathway for quercetin induced CHOP expression, thus contributing to the enhanced apoptotic death of ovarian cancer cells to TRAIL. Quercetin could be an attractive candidate for combined chemotherapy against cancer.

Saracatinib impaired peritoneal dissemination of 44As3Luc scirrhous gastric carcinoma cells that are resistant to Met and FGFR inhibition.

EBV-positive diffuse large B-cell lymphoma (DLBCL) of the elderly is newly classified as a subtype of DLBCL in the 4th WHO classification. Comprehensive genetic analysis has not been investigaed. We identified the activation of JAK-STAT and NF-κB pathways was characteristic of the disease.

Immunohistochemical analysis of 137 epithelial ovarian cancer specimens revealed that high levels of REV7 expression were detected in clear cell carcinomas (CCC), and were associated with poor prognosis of advanced epithelial ovarian cancer. REV7 depletion in CCC cells enhanced sensitivity to cisplatin in vitro and in vivo, suggesting that REV7 could be a molecular target for CCC therapy.

Bone resorption facilitates cancer cell colonization of osteoblastic bone metastasis. We revealed that insulin-like growth factor-1 released from the bone during bone resorption and hypoxia-inducible factor activity cooperatively promote cancer cell colonization in hypoxic bone marrow.

We identified 131 genes that were differentially upregulated in mTECs. Functional analysis using siRNA-mediated gene silencing revealed five novel TEC markers that were involved in the proliferation or migration of mTECs. The expression of DEF6 and TMEM176B was upregulated in tumor vessels of human renal cell carcinoma (RCC) specimens, suggesting that they are potential targets for antiangiogenic intervention for RCC.

p62/SQSTM1 (p62) is a multifunctional protein implicated in several signal transduction pathways and selectively degraded by autophagy, a process for lysosomal degradation of protein and organelle. Results of our present study revealed that p62-silencing resulted in the formation of mis-regulated multilayer autophagosomes and an autophagic cell death, and p62 can therefore be an attractive target for the development of anti-neoplastic agents.

Most patients with a preoperative diagnosis of ductal carcinoma in situ of the breast had no metastasis or only micrometastasis in axillary nodes, even though invasive disease was found on final pathology. Predictors of the invasive disease were not completely consistent with those of nodal metastasis. Therefore, the selective application of sentinel node biopsy in patients with a higher risk of invasive disease may not accurately identify the patients with a higher likelihood of sentinel node metastasis.

The genetic features of primary intraocular lymphoma (PIOL) have not yet been elucidated. We carried out single nucleotide polymorphism array karyotyping of IOL using genomic DNA extracted from vitreous fluid. Recurrent copy number gain regions in PIOLs were detected most frequently on chromosome 1q followed by 18q and 19q. There was a correlation between gain of the IL-10 gene located on 1q and intravitreal interleukin-10 concentration, which was higher in IOL than in benign uveitis.

In this study, we explored the possible roles of GATA4 in human breast cancer. GATA4 immunoreactivity was positively associated with distant metastasis, and outcome analyses revealed that GATA4 immunoreactivity was associated with shorter disease-free and breast cancer-specific survival of the patients. These data may suggest important roles of GATA4 in the process of breast cancer progression.

In the present study, we examined 10 DFL, 18 NFL, 10 gastric MALT lymphoma samples by gene expression analysis. Gene expression profiles of the 3 lymphoma types were compared using 2918 differentially expressed genes (DEGs) and results suggested that DFL shares characteristics of MALT lymphoma. Increased expression of CCL20 and MAdCAM-1 and co-expression of CCL20 and CCR6 may play an important role in tumorigenesis in DFL.

The ALA-based fluorescence detection assays detected bladder cancer cells in urine sediments of low-grade and low-stage bladder urothelial cells at higher rate than conventional urine markers. The ALA-based assay are promising tool for the management of bladder cancer.