Aging Brain and Alzheimer's Disease: Journal of Neuroscience Research: Vol 70, No 3

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Journal of Neuroscience Research: Volume 70, Issue 3

Special Issue:Aging Brain and Alzheimer's Disease

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Preface

Preface

Perspectives

Age-related decline in neurogenesis: Old cells or old environment?

Mini-Reviews

SCG10-related neuronal growth-associated proteins in neural development, plasticity, degeneration, and aging

Research Articles

Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade

Age-related changes in central nervous system phosphatidylserine decarboxylase activity

Turnover of synaptic membranes: Age-related changes and modulation by dietary restriction

Age-related deficits in long-term potentiation are insensitive to hydrogen peroxide: Coincidence with enhanced autophosphorylation of Ca2+/calmodulin-dependent protein kinase II

Ultrastructural analysis of the paranodal junction of myelinated fibers in 31-month-old-rats

Attenuated transcriptional responses to oxidative stress in the aged rat brain

Expression patterns of immature neuronal markers PSA-NCAM, CRMP-4 and NeuroD in the hippocampus of young adult and aged rodents

4-Methylcatechol stimulates phosphorylation of Trk family neurotrophin receptors and MAP kinases in cultured rat cortical neurons

Effects of enriched environments with different durations and starting times on learning capacity during aging in rats assessed by a refined procedure of the Hebb-Williams maze task

Golden mean to longevity: Rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease

Commentary

Amyloid-β: A vascular sealant that protects against hemorrhage?

Perspectives

Role of mitochondrial dysfunction in Alzheimer's disease

Mini-Reviews

Cholesterol and pathological processes in Alzheimer's disease

Alzheimer's disease with spastic paresis and cotton wool type plaques

β-secretase as a target for the treatment of Alzheimer's disease

Reviews

Death and survival of neuronal cells exposed to Alzheimer's insults

Alzheimer's disease: β-Amyloid protein and tau

Neuroplasticity in Alzheimer's disease†

Research Articles

Amyloid β-protein affects cholesterol metabolism in cultured neurons: Implications for pivotal role of cholesterol in the amyloid cascade

Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease

Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer's disease

Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling

In vivo conversion of racemized β-amyloid ([D-Ser26]Aβ1–40) to truncated and toxic fragments ([D-Ser26]Aβ25–35/40) and fragment presence in the brains of Alzheimer's patients

Novel cognitive improving and neuroprotective activities of Polygala tenuifolia Willdenow extract, BT-11

Region-specific reduction of Aβ-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging

Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice

Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology

Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine

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Highlighting Neuroscience at Minority Serving Institutions (MSIs)

Guest Editor(s):

Tackling the opioid crisis: novel mechanisms and clinical perspectives

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Glia and Alcohol use Disorders

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Women in Neuroscience

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Age-related deficits in long-term potentiation are insensitive to hydrogen peroxide: Coincidence with enhanced autophosphorylation of Ca²⁺/calmodulin-dependent protein kinase II

Neuroplasticity in Alzheimer's disease ^†

In vivo conversion of racemized β-amyloid ([D-Ser²⁶]Aβ1–40) to truncated and toxic fragments ([D-Ser²⁶]Aβ25–35/40) and fragment presence in the brains of Alzheimer's patients