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Migraine is a common neurologic disorder. We identified consistent regional neural activity alteration in migraine patients using anisotropic effect-size seed-based d mapping (AES-SDM), activation likelihood estimation (ALE), and multi-level kernel density analysis (MKDA). The findings revealed consistent abnormal brain activities which deepen our understanding of the pathological mechanism of migraine.

We identify age-dependent regression in sensory and social behaviors in a female mouse model for Rett syndrome. The behavioral regression coincides with changes in perineuronal nets and wild-type MeCp-2 protein expression in primary somatosensory cortex of adolescent and adult MECP2-heterozygous mice.

This review summarizes the latest MRI studiesinvestigating critical aspects of MS, such as atrophy, demyelination,neuroaxonal damage and neuroinflammation, in mouse models of MS.

PKCβ was activated, evoking microglia activation and p38 MAPK phosphorylation, resulting in morphine-induced scratching. Whereas nalbuphine interrupts PKCβ activation and inhibits microglia/p-p38 MAPK pathway, is via activate KOR-PKCδ pathway. PKCβ and PKCδ compensate each other in MIS when one is absent.

Orexin-A (OXA) injected into the ventrolateral preoptic area (VLPO) of the hypothalamus increases time spent awake, alters the power spectrum of sensorimotor cortical electroencephalographic activity during sleep and awake states, and enhances muscle activity. These results indicate that OXA may increase excitability of the sensorimotor cortex, which might explain the corresponding increase in awake time, muscle tone, and spontaneous physical activity, following central OXA administration.

Metabolic syndrome (MetS) disorders such as diabetes increase the risk of developing age-related dementia. The present study shows that the KKAy mouse model of MetS develops cognitive impairments that are concomitant with pathological tau and reduced O-GlcNAc signaling in the brain.

Zebrafish dnm1a, ortholog of mammalian DNM1, has a nervous tissue-specific expression pattern and plays a role in the formation of both axon and synapse. This graphical abstract was created with BioRender.com.