The cover image is based on the Research Article Expression of tau and phosphorylated tau in the brain of normal and hemiparkinsonian rhesus macaques by Julia C. Gambardella et al., https://doi.org/10.1002/cne.25490.

Nonhuman primates exhibit sexual dimorphism in behavior, suggesting that there could be underlying differences in brain organization and function. Females showed significantly higher fractional anisotropy than males in regions of frontal-parietal white matter in the right cerebral hemisphere. These anisotropy values were non-overlapping between males and females.

Pseudocolor cluster maps and regression models describing normal, age-related change in the ganglion cell layer, inner plexiform layer, and inner segment–outer segment region of photoreceptors, as derived from optical coherence tomography data.

Pathological changes in the medial prefrontal cortex (mPFC) and astrocytes are closely associated with Alzheimer's disease (AD).

Confocal image showing the demarcation of neuropils in a layer of the central brain (cerebrum) of the honey bee. Distinct anti-synapsin immunolabeled neuropils are depicted by different colors. The study by Habenstein et al. provides a detailed 3D atlas of neuropils and tracts in the honeybee brain.

Accumulation of the neuronal protein tau had been linked to neurodegenerative disorders. Rhesus macaques are widely used for studying aging and neurodegenerative disorders, yet little is known about the natural expression of tau in their brains. Here, we demonstrate that tau is present across brain regions in normal and hemiparkinsonian rhesus macaques detected by immunohistochemical methods. Tau is found in neuronal soma and fibers of gray matter brain regions and oligodendrocytes in white matter brain regions. Both 3R and 4R tau isoforms are detected. Tau phosphorylated at Thr231, but not Ser202/Thr205 (AT8), is also present. Nigral dopaminergic (TH+) cell loss associated to neurotoxin-induced hemiparkinsonism did not affect tau expression as the protein is mainly expressed in nigral GABAergic (GAD67+) cells.