Encyclopedia of Reagents for Organic Synthesis
What's New
NEW ARTICLES - The Editor-in-Chief, Philip Fuchs, and the Editors, André Charette, Tomislav Rovis, and Jeffrey Bode are regularly selecting, commissioning, updating and editing new reagents and catalysts. The latest new articles are listed below.
The 2022 EROS Best Reagent Award, sponsored by Aldrich®Chemistry and Wiley, goes to Olafs Daugulis at University of Houston, USA, for the reagent 8-Aminoquinoline. View the winning article here.
Find out more about the award here.
BUILD 53 ARTICLES
Triphenylbismuthine (Update!)
Bis(cyclopentadienyl) Cobalt (Update!)
Eosin Y (Update!)
Bis[2,9-bis(4-Methoxyphenyl)-1,10-Phenanthroline-N1,N10]-Copper Chloride (Cu(dap)2Cl) (New!)
Rose Bengal (New!)
O-(Diphenylphosphinyl)hydroxylamine (Update!)
Tetrahydroxydiboron (Update!)
N-Vinylphthalimide (New!)
Cobalt(II) Bis(trifluoromethanesulfonate) (New!)
Tetrafluoro-1,4-Dihydro-1,4-Ethenonaphthalene (Tetrafluorobenzobarrelene, TFB) (New!)
Dirhodium(II) Tetrakis[N-Tetrafluorophthaloyl-(S)-tert-Leucinate] (New!)
2,2,2-Trichloroethyl-N-mesyloxycarbamate (New!)
Hydroxy(methanesulfonato-KO)phenyl Iodine (New!)
Dichloro(1,10-phenanthroline)nickel (New!)
2,6-Bis-[1-(2-t-butylphenylimino)ethyl]pyridine (New!)
Chlorine Monofluoride (New!)
Tetramethylammonium Pivalate (New!)
N-methylbicyclo[2.2.1]hept-2-ene-2-carboxamide (New!)
(T-4)-Dichloro[N,N′-(1,2-dimethyl-1,2-ethanediylidene)bis[2,6-bis(1-methylethyl)benzenamine-κN]]iron (New!)
(R,S) and (S,R) N-Trip Indanol Triazolium NHC Catalysts (New!)
BUILD 52 ARTICLES
3-Azido-2-methylbut-3-en-2-ol (New!)
Benzoxaborole (New!)
1,2-Diphenyl-1,1,2,2-tetrahydroperoxyethane (New!)
4-Methyl-1-phenyl-2,3-dihydro-1H-Phosphole 1-Oxide (New!)
Thionyl Fluoride (New!)
Spiro[cyclopenta[2,1-b:3,4-b′]dipyridine-5,9′-fluorene] (New!)
(((2S,3R)-2,3-Diphenylaziridin-1-yl)imino)-λ4-sulfanone (New!)
BUILD 51 ARTICLES
(R)-1-[2-(Diphenylphosphino)phenyl]ethylamine (New!)
1,1′-(Phenyl-λ3-Iodanediyl)bis(pyridinium) Trifluoromethanesulfonate (New!)
BUILD 50 ARTICLES
Hydroxylamine-O-Sulfonic Acid (Update!)
1-Butanaminium, N,N,N-Tributyl-Eicosa-μ-Oxodi-μ5-Oxodecaoxodecatungstate(4−) (4:1) (Update!)
Triisopropylsilane (New!)
1,1,2,2-Tetrakis(dimethylamino)ethene (New!)
1,1-Dioxido-3-oxo-1,2-benzisothiazol-2-yl Selenocyanate (New!)
1-Dodecanethiol (New!)
2-Propanol, 1,1,1,3,3,3-Hexafluoro-2-(trifluoromethyl)-, Aluminum Salt (3:1) (New!)
Thiophene, 2,3,4,5-Tetrabromo-, 1,1-Dioxide (SOgen) (New!)
Phenyl Chlorothionocarbonate (Update!)
BUILD 49 ARTICLES
Chloroiodomethane (ICH2Cl) (Update)
Potassium Hydrogen Fluoride, KHF2 (Update)
Magnesium Perchlorate (Update)
Triethylsilyl Trifluoromethane (Update)
Fluoroiodomethane (Update)
Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methane (Update)
Vanadium(1+), Tri-μ-Chlorohexakis(tetrahydrofuran)di-, Di-μ-Chlorotetrachlorodizincate(2-) (2:1) (New)
1-Acryloxyl-1H-pyrazole (New)
1,1,2,2-Tetrakis(morpholino)ethylene (TME) (New)
Di-μ-chlorobis[(1,2,3-η)-1-(1,1-dimethylethyl)-1H-inden-1-yl]dipalladium (η3-1-t-Bu-indenyl)2Pd2Cl2) (New)
1,3,5,7-Tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.1]decane (New)
5-Methyl-3-nitro-2(1H)-pyridinone (New)
BUILD 48 ARTICLES
Methyl Phenyl Sulfone (Update)
Bromochloromethane (BrCH2Cl) (Update)
Difluoromethyl Phenyl Sulfone (Update)
Tetrabutylammonium Azide (Update)
Difluoromethyl 2-Pyridyl Sulfone (Update)
N-Tosyl-4-chlorobenzenesulfonimidoyl Fluoride (SulfoxFluor) (Update)
Bromoiodomethane (New)
2-Methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (New)
2-Methoxy Pyridine (New)
2-(Aminooxy)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)acetamide (New)
Diethyl [(allyloxy)methyl] phosphonate (New)
2-(2-Ethoxy-2-oxoethyl)-1,1,3,3-tetramethylthiouronium bromide (New)
3-(4-Methoxyphenyl)-3-oxetanesulfonyl Fluoride (New)
3-Phenyl-3-(trifluoromethyl)-3H-diazirine (New)
N-Isopropyl-N,2-dimethylpropan-2-amine (New)
S-(Trifluoromethyl)benzothioate (TFBT) (New)
1,3-Benzenedicarbonitrile, 2,4,5,6-Tetrakis(diphenylamino)- (New)
1,3,5-Trimethoxybenzene (New)
BUILD 47 ARTICLES
1,1′-Bis(diphenylphosphino)ferrocene (Update)
2,6-Bis((2-(hydroxydiphenylmethyl)-1-pyrrolidinylmethyl)-4-methylphenol (ProPhenol) (Update)
3,5-Dimethyl-1-pyrazolylformaminidium Nitrate (New)
Crotyloxymethyltriphenylphosphonium Chloride (New)
Diethyl ((Allylthio)methyl)phosphonate (New)
Allyl Formate (New)
Pyridinium, 1-Amino-2,4,6-Triphenyl-, Perchlorate (and Tetrafluoroborate) Salt (New)
Hydrido(N,N′-bis(2,6-diisopropylphenyl)pentane-2,4-diiminato)zinc(II) (New)
BUILD 46 ARTICLES
2-Iodothiophene (New!)
2,3-Diiodobenzo[b]thiophene (New!)
N-Sulfinyl-O-(tert-Butyl)Hydroxylamine (New!)
(1,5-Cyclooctadiene)(tetramethyl-p-benzoquinone)nickel (New!)
N-Methylglycine (New!)
1H-Indole-1-carbodithioic, 5-Bromo, Potassium Salt (1:1) (New!)
Chloro(η5-Cyclopentadienyl)Bis(Triphenylphosphine)Ruthenium(II) [and Related CpRuX(PR3)2 Complexes] (New!)
5-Aminotetrazole (New!)
3CzClIPN (New!)
1,3,2-Dioxaborolane, 2-Ethenyl-4,4,5,5-tetramethyl (Vinylboronic Acid Pinacol Ester) (New!)
Carbamoyl Anion (New!)
8-Aminoquinoline (Update!)
Potassium O-Ethyl Xanthate (Update!)
BUILD 45 ARTICLES
2-(Difluoromethanesulfonyl)-1,3-Benzothiazole (BTSO2CF2H) (New!)
2,2′-Bipyridine (New!)
Tetra(2,4,6-trimethylbenzoyl)germane (New!)
Tetra(benzoyl)germane (New!)
Hydroxy(triflyloxy)copper(II) Bis(N-methylimidazole) Complex (New!)
3,5-Dimethyl Aniline (New!)
Trimethylsilylmagnesium Iodide (New!)
3-Bromo-N,N,N-trimethylanilinium Iodide (1:1) (New!)
trans-Bis(acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II) (Herrmann–Beller Catalyst) (New!)
Pyridine-3-sulfonic Acid (New!)
Potassium Ethyl Trithiocarbonate (New!)
Pyridinium, 1-[[(trifluoromethyl)sulfonyl]oxy]-, 1,1,1-trifluoromethanesulfonate (New!)
(2E)-3-(Tributylstannyl)-2-propenoic acid (New!)
2-Aminopyridine (New!)
Iridium Pyridine-Thienyl (Ir-PYT) Catalyst for C&bond;H Borylation (New!)
(Z)-N-Phenoxybenzimidoyl Chloride (New!)
2-Amino-1-benzenesulfonic Acid (New!)
Bromoacetic Acid (New!)
trans,trans-Farnesyl Bromide (New!)
Bis[5,5-dimethyl-1-(4-methylpiperazin-1-yl)-1,2,4-hexanetrionato-κ2O,κ4O]cobalt(II) (New!)
2-Hydroxy-1,4-Naphthoquinone (New!)
Nicotinamide Adenine Dinucleotide (Phosphate) – NAD(P)/NAD(P)H1–7 (New!)
2,5-Dibromothiophene (New!)
Iodoacetic Acid (New!)
Methylazanyl 4-Nitrobenzenesulfonate (New!)
4,4′-Dimethoxybenzophenone (New!)
tert-Butyl Nitrite (Update)
(4aR,9aS)-4-Hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one (Update)
BUILD 44 ARTICLES
Di-μ-Bromobis(tri-t-Butylphosphino)Dipalladium(I) (Update)
9-Iodo-9-Borabicyclo[3.3.1]nonane (New!)
5,5-Dioxido-10H-dibenzo[b,e][1,4]thiabismin-10-yl 4-Methylbenzenesulfonate (New!)
Thiourea (Update)
Zinc Phosphide (New!)
3,3-Dimethyl-2-Nitroso-2,3-Dihydrobenzo[d]Isothiazole-1,1-Dioxide (New!)
Tris(trimethylsilyl)silane (Update)
2-(3-(4-Fluorophenoxy)-3-Oxopropyl)Benzenediazonium Hexafluorophosphate (New!)
Nonafluorobutanesulfonyl Fluoride (Update)
Tris[1,1′-[η2-(1E)-1,2-Ethenediyl]bis[4-(Trifluoromethyl)Benzene]]Nickel (New!)
Titanium Dioxide (New!)
Bis(catecholatodiboron) (Update)
2-Tetrahydropyranyl Hydroperoxide (New!)
Pyridine, 2,2′-[1,2-Phenylenebis[Methylene[(1,1-Dimethylethyl)Phosphinidene]]]Bis (New!)
Hexafluoroisopropyl Sulfamate (New!)
N-Nitrosopiperidine (New!)
(Trimethylsilyloxy)Trioxorhenium (Update)
Trifluoromethane Sulfonamide (New!)
p-Nitrobenzenesulfonylhydrazine (New!)
BUILD 43 ARTICLES
Preparation and Uses of tBuS(O)Cl(Update)
Divinyl Sulfone(Update)
N-Acetoxyphthalimide(New!)
Copper(II) Fluoride(Update)
Mercury(II) Oxide(Update)
2,2,2-Trifluoroethyl(mesityl)iodonium Triflate(New!)
Chloro(1,5-Cyclooctadiene)Rhodium(I) Dimer(Update)
3,5-Diaza-1-Azonia-7-Phosphatricyclo[3.3.1.13,7]decane, 1-(4-Sulfobutyl)-, Inner Salt(Update)
Methallyl Isothiocyanate(New!)
Tantalum Methoxide(New!)
Tris(1,1,1,3,3,3-Hexafluoro-2-Propoxy)Silane(New!)
1-Cyano-4-Dimethylaminopyridinium Tetrafluoroborate(New!)
Silica Gel-Supported Sodium Periodate(New!)
4-Phenyl-1,2,4-Triazoline-3,5-Dione(Update)
BUILD 42 ARTICLES
2-(Pyrimidin-5-yl)benzaldehyde1(New!)
2-Fluoro-6-(pyrimidin-5-yl)aniline1(New!)
1,1,1-Trifluoro-2,2-Dichloroethane(New!)
(Z)-1,4-Dimethoxy-1,4-dioxo-3-(pyridin-1-ium-1-yl)but-2-ene-2-thiolate(New!)
2,5-Cyclohexadiene-1-Carbonitrile, 1-(1-Methylethyl)(New!)
Magnesium Hemithioacetate(New!)
4-Nitro-1-((Trifluoromethyl)sulfonyl)-Imidazole(New!)
O-Pivaloyl Hydroxylamine Triflic Acid(New!)
2-(Dicyclohexylphosphino)-3,6-Dimethoxy-2′,4′,6′-Triisopropyl-1,1′-Biphenyl(New!)
Diethyl (1-Diazo-2-oxopropyl)phosphonate1(New!)
Di-Tert-Butyl Hyponitrite(Update)
(1,5-Cyclooctadiene)bis(2-Me-allyl)ruthenium(II)(Update)
(Difluoromethyl)trimethylsilane (TMSCHF2)(Update)
Azobisisobutyronitrile (AIBN)(Update)
1,1,1,3,3,3-Hexafluoro-2-propanol(Update)
Diazomethane, CAS No. 334-88-3(Update)
BUILD 41 ARTICLES
[4-(Acetylamino)phenyl]imidodisulfuryl Difluoride(New!)
Lithium Tetra(pentafluorophenyl)borate(Update)
1,3-Propanediol Dinitrite(Update)
2,2-Dimethyl-1,3-Propanediol Dinitrite(New!)
2,4-Dinitrobenzenesulfenyl Chloride(Update)
1-[(Phenylsulfonyl)difluoromethyl]-1,3-dihydro-3,3-dimethyl-1,2-benziodoxole(New!)
2-tert-Butyldimethylsilyl-1,3-Dithiane(Update)
N-Dichloromethylene-N,N-Dimethyliminium Chloride(Update)
1,4-Dinitroimidazole(New!)
BUILD 40 ARTICLES
Cerium(III) Chloride(Update)
1-Hydroxy-1,2-Benziodoxol-3(1H)-One(Update)
N-(Carboxymethyl)-N-Methyl-Glycine(Update)
Tetramethylchloroformamidinium Hexafluorophosphate(New!)
tert-Butyl (Z)-((1H-pyrazol-1-yl)((2,2,2-Trifluoroacetyl)imino)methyl)carbamate
Soluble Flavocytochrome P450BM3 and Its Mutants(New!)
Ir(dFppy)3(New!)
Tris(dipivaloylmethanato)Manganese(New!)
N-Tosyl-4-chlorobenzenesulfonimidoyl Fluoride (SulfoxFluor)(New!)
Thiophene, 2-Bromo-5-methyl-(New!)
1,3,2-Dioxaborolane, 2-[3-(Dimethylphenylsilyl)bicyclo[1.1.1]pent-1-yl]-4,4,5,5-tetramethyl-(New!)
POSOP(New!)
4-Methyl-1,2,4-triazoline-3,5-dione(New!)
Sulfonium, (Fluoromethyl)phenyl(2,3,4,5-tetramethylphenyl)-, Tetrafluoroborate(1-) (1:1)(New!)
3-Phenylpropyl (Tetrahydropyran-2-yl) Peroxide(New!)
2,4,6-Tris(p-methoxybenzyloxy)-1,3,5-triazine (TriBOT-PM)(New!)
1,3-Di-Boc-2-(trifluoromethanesulfonyl)guanidine
Sodium 2-Methyl-2-Propanethiolate
trans-N1,N2-Dimethyl-1,2-Cyclohexanediamine(New!)
1,4-Dithiane-2,5-diol(New!)
Chloro[di(1-adamantyl)-2-dimethylaminophenylphosphine]gold(I)(New!)
Tributylsulfoammonium Betaine(New!)
Thiocyanic Acid, 1,1-Dioxido-3-oxo-1,2-benzisothiazol-2-yl Ester(New!)
N-Thiocyanato-Dibenzenesulfonimide(New!)
N-(Cyanosulfanyl)-2,4,6-trimethylaniline(New!)
BUILD 39 ARTICLES
Dimethyldioxirane (DDO)(Update)
1-Fluoro-2,4,6-trimethylpyridinium Tetrafluoroborate(Update)
N-(Triphenylphosphoranylidene) Isocyanamide(Update)
Bis[1,3-bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene]-μ-hydroxy di(gold)(Update)
Benzenemethanamine, α,α-Diphenyl-N-Sulfinyl-(New!)
Benzophenone(New!)
(2-Nitrophenyl)phenyliodonium Fluoride(New!)
3-Methyl-1,4,2-dioxazole-5-one(New!)
2,6-Difluorophenyl Sulfamate(New!)
Bismuth Trifluoride(New!)
2-(Diphenylmethyl)pyridine(New!)
PhenoFluor, PhenoFluorMix, and AlkylFluor(New!)
3-Mercaptopropionitrile(New!)
3,3′-Dithiobis(propionitrile)(New!)
1,3-Hexafluoroxylene(New!)
(Triphenylphosphonio)Difluoroacetate(New!)
Benzyl Diphenylphosphine(New!)
Dimethyl Malononitrile(New!)
2-(Pyrimidin-5-yl)aniline(New!)
4′-Hydroxy-[1,1′-biphenyl]-2-carbonitrile(New!)
4′-((Diisopropylsilyl)methyl)-[1,1′-biphenyl]-2-carbonitrile(New!)
Difluoroacetaldehyde N-Triftosylhydrazone (DFHZ-Tfs)(New!)
Tricyclopropylphosphine(New!)
Thallium Cyclopentadienide(New!)
BUILD 38 ARTICLES
Pentafluorosulfanyl Chloride(Update)
Tetrabutylammonium Difluorotriphenylsilicate (TBAT)(Update)
(R) and (S)-2,2′-Diphenyl-[3,3′-biphenanthrene]-4,4′-diyl Hydrogen Phosphate (VAPOL PA)(New!)
5′-Methyl[2,2′-bipyridine]-5-methanesulfonic Acid, Tetrabutylammonium Salt(New!)
Ferric Oxalate Hexahydrate(New!)
BUILD 35a ARTICLES
O-(tert-Butyldimethylsilyl)hydroxylamine(Update)
Copper Bronze(Update)
Ethyl Lithiopropiolate(Update)
9-Fluorenylmethyl Chloroformate(Update)
N-Fluoro-N-(phenylsulfonyl)benzenesulfonamide(Update)
N-Cyano-4-Methyl-N-Phenyl-Benzenesulfonamide (NCTS)(Update)
2-Bromo-6-Isocyanopyridine(New!)
N,N,N′,N′-Tetramethyl-7,8-Dihydro-6H-Dipyrido[1,2-α;2′,1′-c][1,4]diazepine-2,12-diamine(New!)
Isocyanomethyltriphenylphosphonium Chloride(New!)
Iodine, [1,2-Benzenedicarboxylato(2-)-O1,O2]Phenyl-(New!)
N-Thiocyanatosuccinimide(New!)
N-Thiocyanatophthalimide(New!)
1-Propanone, 3-Amino-1-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-(New!)
Dibenz[b,f]Azocine,11,12-Didehydro-5,6-Dihydro-(New!)
N-[(Methylsulfonyl)oxy]ethanimidoyl Chloride(New!)
Ethyl 2-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)thio]-2,2-difluoroacetate(New!)
Dibenzo[a,e]cyclooctatetraene(New!)
Allylsamarium Bromide(New!)
Pentafluorophenol(Update)
1,1′-Thiocarbonyldiimidazole(Update)
BUILD 35 ARTICLES
tert-Butyl Chloromethyl Ether(Update)
t-Butyldiphenylchlorosilane(Update)
Ethoxyacetylene(Update)
Fluorosilicic Acid(Update)
Formylmethylenetriphenylphosphorane(Update)
[Hydroxy(tosyloxy)iodo]benzene(Update)
Montmorillonite K10(Update)
Schwesinger Base, Polymer-supported(Update)
Pseudoephedrine(Update)
Proazaphosphatranes (i-but), Proazaphosphatranes Me)(Update)
Tetrahydroxydiboron(Update)
Iron(II) Trifluoromethanesulfonate(Update)
Fmoc-Asp(OtBu)-(Dmb)Gly-OH(New!)
Benzamide(New!)
Acetic Acid, 2-Isocyano-, 1,1-Dimethylethyl Ester(New!)
1-Amino-2-Methyl-3-Buten-2-ol(New!)
Benzenesulfonamide, N,4-Dimethyl-N-[(trifluoromethyl)thio](New!)
Acetaldehyde, 2-(Diphenylphosphino)-Phenyl Phosphonium Dimer(New!)
Sodium Benzenesulfinate(Update)
Tetrachlorocyclopropene(Update)
Trifluoromethyl Hypofluorite(Update)
3-Trimethylsilyl-1-propyne(Update)
Triphenylphosphine–Carbon Tetrabromide(Update)
Zinc–1,2-Dibromoethane(Update)
Previous update (April 2019):
BUILD 34 ARTICLES
Tetrafluoro-p-benzoquinone (update)
Pentafluorophenylboronic Acid (update)
PhanePhos and Related Derivatives (update)
(Bicyclo[2.2.1]hepta-2,5-diene)[(2S,3S)-bis(diphenylphosphino)butane]rhodium Perchlorate) (update)
p-Nitrobenzenesulfonyloxyurethane (update)
N,N,N′,N″,N″‐Pentamethyldiethylenetriamine (update)
9-Fluorenylmethyl Pentafluorophenyl Carbonate (update)
2-Dicyclohexylphosphino-2′,6′-diisopropoxy-1,1′-biphenyl (update)
Tris(dimethylamino)sulfonium Difluorotrimethylsilicate (update)
Pentafluorophenyl Diphenylphosphinate (FDPP) (update)
Silyl Ethynyl Benziodoxolone Reagents (update)
Chlorotris(triphenylphosphine)cobalt (update)
(R,R)- and (S,S)-Diphenylethylenediamine (update)
Bromonitromethane (update)
Diphenylsilane (update)
N,N′‐Bis(2,6-diisopropylphenyl)imidazol-2-ylidene Gold(I) Chloride (update)
Trimethylsilylmethyllithium (update)
Aluminum, [μ-(1,4-Diazabicyclo[2.2.2]octane-κN1:κN4)]hexamethyldi (update)
Trifluoromethanesulfonyl Chloride (update)
Tris(pentafluorophenyl)borane (update)
1,3-Dihydroimidazolone (new)
Bis(norbornadiene)rhodium(I) Tetrafluoroborate (new)
(R)-(+)-2,2′-Bis(di-2-furanylphosphino)-6,6′-dimethoxy-1,1′-biphenyl (new)
Silver Trifluoromethanolate (new)
Hexahydro-1,3,5-tris(4-methoxyphenyl)-1,3,5-triazine (new)
Methanesulfenic Acid, 1,1,1-Trifluoro-,1-methyl-1-phenylethyl Ester (new)
4-Hydroxy-4-methylpent-1-en-3-one (new)
H-Naphtho[1,8-de]-1,3,2-diazaborine, 2,3-dihydro- (new)
Bicyclo[2.2.2]octane-2,5-dione (new)
Tris(trimethylsilyl)amine (new)
Difluoromethyl Triflate (new)
N-Chloro-N,4-dimethylbenzenesulfonamide (new)
1,3-Propanediol Dinitrite (new)
Diethyl Difluoro(trimethylsilyl)methylphosphonate (new)
3-Chloro-2-fluoropropene (new)
Dimethoxymethylsilane (new)
Allyl Chloromethyl Ether (new)
Dimethylmalononitrile (new)