Pediatric Discovery is a platform for publishing and discussing significant and state-of-the-art basic, translational, and clinical discoveries affecting child and adolescent health and disorders in all aspects of pediatric medicine.

We’re a pediatrics journal advancing the health and well-being of infants, children, and adolescents by disseminating novel discovery and knowledge in the field. Proudly accessible - every issue is open to the world.

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The journal does not charge any submission fees. The Article Publication Charge (APC) is currently waived for accepted manuscripts.

Articles

RESEARCH ARTICLE
Open access

Early Forays Into Using Spinal Anesthesia for Inguinal Hernia Surgery in Preterm Infants: A Retrospective Analysis From a Single Center in Karnataka

Ranganatha A. Devaranavadagi, Gayatri Sasikumar, Pavitra Gangadharan Chandrasekaran, Netra S. Kannur, H. A. Venkatesh, Suma Sriramanan, C. N. Radhakrishnan, Jayashree S. Simha, Karthik Nagesh, 
  •  24 July 2025

Graphical Abstract

Early Forays Into Using Spinal Anesthesia for Inguinal Hernia Surgery in Preterm Infants: A Retrospective Analysis From a Single Center in Karnataka Issue ,

Preterm infants are at high risk of cardiopulmonary complications with general anesthesia during inguinal hernia repair. This study evaluated 19 preterm infants who underwent spinal anesthesia and found that none required respiratory or inotropic support. Spinal anesthesia was safe and effective, avoiding both NICU admission and respiratory escalation—even in infants with bronchopulmonary dysplasia.

RESEARCH ARTICLE
Open access

Thiostrepton Suppresses the Progression of Rhabdomyosarcoma by Inhibiting the PI3K‐AKT Signaling Pathway

Yu Wang, Peng Hong, Zhiqiang Gao, Wei Ma, Zaihong Hu, Jie Lin, Kongkong Cui, Qinlin Shi, Xiao-Mao Tian, Guanghui Wei, 
  •  29 June 2025

Graphical Abstract

Thiostrepton Suppresses the Progression of Rhabdomyosarcoma by Inhibiting the PI3K-AKT Signaling Pathway Issue ,

The study establish TST as a multi-mechanism PI3K-AKT inhibitor for refractory RMS while validating Cmap-driven drug repurposing for pediatric oncology.

RESEARCH ARTICLE
Open access

Protective Effects of the Ketogenic Diet on Cognitive Impairment Induced by Status Epilepticus in Rats: Modulation of Neuroinflammation Through the NF‐κB Signaling Pathway

Wandi Wang, Lingman Wang, Chunxue Jiang, Shengxuan Zhang, Chen Tan, Liqiong Peng, Ran Ding, Bing Tian, Xiaojie Song, Li Jiang, 
  •  23 June 2025

Graphical Abstract

Protective Effects of the Ketogenic Diet on Cognitive Impairment Induced by Status Epilepticus in Rats: Modulation of Neuroinflammation Through the NF-κB Signaling Pathway Issue 2, 2025

Ketogenic diet has therapeutic effects on neurocircuitry damage and cognitive impairment due to status epilepticus in rats by modulating the NF-κB signaling pathway.

CASE REPORT
Open access

Acute Genitourinary Pain and Swelling in a Child‐Look Out for the Rashes!

Frankel Lin, Jasmine Huang, Sudipta Roy Chowdhury, 
  •  21 June 2025
REVIEW
Open access

A Review of the Current State of Off‐Label Therapies for Pediatric Inflammatory Bowel Disease

Yassin EL-Najjar, Mary-Joe Touma, Shuai Tan, Xiaoqin Zhou, Qi Liu, 
  •  17 June 2025
More articles

The most read articles published in the Last 2 Years

Open access

Sleep‐related disorders in children: A narrative review

Yogev Cohen, Joel Reiter, Alex Gileles-Hillel, 
Open access

Neonatal hepatitis B vaccination: Reevaluating timing and adjuvants for enhanced safety and effectiveness

Aleksandar Cirovic, Ana Cirovic, Ana Ivanovski, Petar Ivanovski, 
Open access

Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinnings

Ethan S. Wong, Daniel A. Hu, Lily Zhang, Rachel Qi, Cindy Xu, Ou Mei, Guowei Shen, Wulin You, Changqi Luo, Tong-Chuan He, Russell R. Reid, Lewis S. Shi, Michael J. Lee, Yi Zhu, 
Open access

Pediatric heart failure classification based on left ventricular ejection fraction

Shan Huang, Xue Xiang, Xu Zhu, Jie Tian, Bo Pan, Min Zheng, 

Graphical Abstract

Pediatric heart failure classification based on left ventricular ejection fraction Issue 3, 2023

Left ventricle ejection fraction is an essential and helpful indicator for PHF classification and management.

Open access

Impact of growth hormone on scoliosis

Xin-Kai Zhang, Xiang Li, Ming-Yan Shi, Man Zhang, Pei-Kang Wang, Hai-Lun Yao, Xin Tan, Xiang Yu, Yu-Fei Shao, Xing Liu, 
Open access

Retinoic acids and nuclear receptor signaling in liver development: Pathogenic roles in liver diseases

Wen Jia, Yang Bi, 
Open access

Cardiomyocyte proliferation and regeneration in congenital heart disease

Jialiang Liang, Xingyu He, Yigang Wang, 
Open access

Comparison of the main pathogenic microorganisms of various common oral diseases in children and adults

Siqi Zhou, Tong-Chuan He, Yuxin Zhang, Hongmei Zhang, 
Open access

Metronomic chemotherapy in pediatric neuroblastoma

Yi Jiang, Chengjun Xi, Chao Yang, 
Open access

Patient‐reported outcome measures in pediatrics: An overview of reviews

Ruobing Lei, Jin Xiong, Haiyun Wang, Yuehuan Li, Janne Estill, Qiu Li, Yaolong Chen, 

Graphical Abstract

Patient-reported outcome measures in pediatrics: An overview of reviews Issue 4, 2024

This study found that the diversity in the target diseases and measurement content was limited in pediatric PROMs. The age from which children should self-report the measurements differed across PROMs, and some definitions were unclear. In addition, reporting of psychometric properties for SR needs improvement, and tailored tools for evaluating the methodological quality of SRs on PROMs are needed.

More articles

Articles with the most citations published in the Last 2 Years according to CrossRef. The citation counts listed reflect the total number of all citations to date.

Open access

Cardiomyocyte proliferation and regeneration in congenital heart disease

Jialiang Liang, Xingyu He, Yigang Wang, 
Open access

Metronomic chemotherapy in pediatric neuroblastoma

Yi Jiang, Chengjun Xi, Chao Yang, 
Open access

Pediatric heart failure classification based on left ventricular ejection fraction

Shan Huang, Xue Xiang, Xu Zhu, Jie Tian, Bo Pan, Min Zheng, 

Graphical Abstract

Pediatric heart failure classification based on left ventricular ejection fraction Issue 3, 2023

Left ventricle ejection fraction is an essential and helpful indicator for PHF classification and management.

Open access

Maternal SARS‐CoV‐2 infection: The potential vertical transmission of SARS‐CoV‐2 and impact on neonates: A review

Wei Xia, Zhoujie Peng, 
Open access

Kikuchi–Fujimoto disease associated with the central nervous system in children

Yuyao Huang, Xinpeng Wang, Ling Wang, Juan Wang, Chengbing Tan, Min Cheng, Yan Jiang, Li Jiang, 

Graphical Abstract

Kikuchi–Fujimoto disease associated with the central nervous system in children Issue 2, 2023

Open access

Astrocytic connexin 43‐hemichannels aggravate seizures by modulating blood‐brain barrier permeability in temporal lobe epilepsy mice

Honghong Song, Yi Li, Jiayu Liu, Xianshu Bai, Li Jiang, Tingsong Li, 

Graphical Abstract

Astrocytic connexin 43-hemichannels aggravate seizures by modulating blood-brain barrier permeability in temporal lobe epilepsy mice Issue 3, 2024

The alterations of connexin 43 (Cx43) hemichannels contribute to the progress of seizures by regulating BBB permeability in temporal lobe epilepsy (TLE). Up-regulated Cx43 accumulated on the astroglial endfeet in the hippocampi of TLE that functioned as hemichannels and thereby disrupted blood-brain barrier (BBB) integrity. Inhibiting the Cx43-hemichannels by TAT-Gap19 reduced the BBB permeability and consequently relieved seizure severity, which may be associated with reduced release of adenosine triphosphate, glutamate and Ca2+ through Cx43 hemmichannels.

Open access

Advances in examination methods for adolescent idiopathic scoliosis

Di Li, Peikang Wang, Man Zhang, Xinkai Zhang, Hailun Yao, Xing Liu, 
Open access

Mechanism and target treatment of primary immunodeficiency diseases with systemic lupus erythematosus‐like phenotype

Shan Liu, Zhiyong Zhang, Xuemei Tang, Xiaodong Zhao, Yunfei An, 
Open access

Improved outcomes of pediatric patients with swallowing disorders through a multidisciplinary dysphagia clinic in a tertiary care children's hospital in Colombia

Silvia J. Galvis-Blanco, Víctor A. Martínez-Moreno, Olga L. Morales-Múnera, Alejandra Wilches-Luna, Claudia L. Losada-Gómez, Silvia Palacio-Petri, Ángela M. Castañeda-Agudelo, Janeth Rosero-Vélez, Leidy J. Torres-Pérez, Laura F. Niño-Serna, 

Graphical Abstract

Improved outcomes of pediatric patients with swallowing disorders through a multidisciplinary dysphagia clinic in a tertiary care children's hospital in Colombia Issue 4, 2024

This study allowed the characterization of pediatric patients with swallowing disorders seen in a multidisciplinary clinic. This overview provides healthcare personnel with an understanding of the complexity of swallowing disorders and their relationships to various medical conditions in children.

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