Pediatric Transplantation

It is crucial to consider kidney function and the exposure to valganciclovir vs. dose alone when determining the risk of neutropenia in pediatric solid organ transplant recipients. Utilizing BSA-based dosing, Cystatin C-based GFR estimation, and appropriate upper limits of GFR for age was associated with a lower rate of neutropenia.

Cardiac allograft tissue concentrations of tacrolimus and mycophenolate acid are correlated with blood levels, whereas those of everolimus showed no correlation. Further, the tissue perfusion efficiencies of tacrolimus and everolimus decreased with age. The relationship between acute cellular rejection and cardiac tissue concentrations could not be elucidated in this study.

After review of suspected EBV-driven Post-Transplant Lymphoproliferative Disorders (PTLD), according to the WHO 2022 criteria, the incidence was 11.7% in our cohort. Non-destructive PTLD was the most common subtype. Spatial/temporal heterogeneity required multiple biopsies. mTOR inhibitors were well tolerated. A diagnostic algorithm was developed to enhance the management of PTLD.

Partial heart transplant grafts remain viable during prolonged cold preservation, far exceeding traditional heart transplant ischemia limits. This breakthrough could revolutionize transplant logistics, enabling wider donor access and reducing wait times for life-saving, growth-capable heart valve implants.

Findings suggest that ChatGPT could be a useful tool for adolescents or caregivers to cover general aspects of kidney transplantation. While the overall scores of accuracy and relevancy are impressive, the presence of potentially risky outputs underscores the necessity for human oversight and validation.

Tacrolimus clearance (CL/F) varies with hemoglobin and cholesterol levels in pediatric kidney transplant recipients, as shown in this retrospective study. Lower hemoglobin increases CL/F, while higher cholesterol reduces it, underscoring the potential for biochemical parameters to enhance therapeutic drug monitoring and dosing strategies.

Survival after allogeneic hematopoietic stem cell transplants (aHSCTs) in the state of Florida since the creation of a state pediatric HSCT consortium has improved. This is significant because it demonstrates that small-sized pediatric HSCT centers can work together in a consortium to improve outcomes similar to larger centers.

Routine pretransplant PGx testing provides frequently actionable data to optimize posttransplant medication regimens, potentially avoiding adverse effects of medications including tacrolimus, azathioprine, HMG-CoA reductase inhibitors, and dapsone, while also providing important information related to thrombosis risk for VTE prophylaxis.

ARD is prevalent among ESKD children. Younger age, lower BMI Z-scores, HTN, and increased Ca × Ph are risk factors for ARD. ARD frequency decreases on ≥ 6-month follow-up of patients.