Quantitative mass spectrometry is designed for accurate quantification of proteins and peptides in a complex biological sample, leading to biomarker discovery and validation. A wide variety of approaches have been developed toward the identification and quantification of proteins with improved quantitative precision, including label-free protein quantification technology and candidate-based multiple-reaction-monitoring approach. The key to successfully measure protein biomarker candidates relies on increased sensitivity and precision. We invite authors to submit original research and review articles that explore aspects of new methodology development in quantitative mass spectrometry and/or applications of quantitative mass spectrometry in biomarker development. Potential topics include, but are not limited to:

• Development of novel and effective methods for mass-spectrometry-based protein quantification
• Development of new strategies to identify and quantify protein biomarkers
• Utilization of high-resolution mass spectrometry for quantitative protein analysis
• New mass-spectrometry-based assay development for biomarker validation
• Data management and new strategies for data analysis