The human and animal body is continuously subjected to oxidative stress due to different biological and non-biological factors. Oxidative stress and free radicals attack the cells through exogenous or endogenous sources which lead to the activation of different defense mechanisms to counteract reactive oxygen species (ROS). These free radical scavengers could be vitamins (C and E) and glutathione (GSH), etc., or antioxidant enzymes like peroxidases, superoxide dismutase, and catalase to mitigate the effect of DNA damage and initiate DNA repair mechanisms.

Excessive generation of ROS and free radicals leads to DNA damage, and mutagenesis through the suppression and mutations of tumor suppressor genes. This phenomenon potentially leads to tumorigenesis. Various repair pathways are activated after the induction of oxidatively induced DNA damage, e.g., mismatch repair (MMR) pathway, nucleotide excision repair (NER) pathway, base excision repair (BER) pathway, non-homologous end joining (NHEJ) pathway, and the homologous recombination (HR), etc. Moreover, various signaling pathways are also involved in the early diagnosis and treatment of various cancers, e.g., hippo signaling, androgen receptor signaling pathway and HGF/Met pathway, etc. All these factors, pathways, and mechanisms play an important role in the diagnosis, prevention, and therapeutic applications of various tumors. Therefore, it is inevitable to explore and study biomarkers related to the oxidative stress, DNA damage, and repair involved in cancer diagnosis and treatment.

This Special Issue aims to attract original research and review articles focusing on how advances in the discovery of novel biomarkers of oxidative stress and DNA damage are involved in various kinds of tumors.

Potential topics include but are not limited to the following:

• Role of oxidatively induced DNA damage in early diagnosis of cancer
• Mechanism of oxidative stress and genotoxicity in tumor generation
• Role of mutagens in cancer
• DNA methylation and histone modification in cancer
• Epigenetic regulation of cancer
• Role of telomerase length in tumorigenesis
• Role of oxidative induced signaling pathways in tumorigenesis
• Oxidative induced cytogenetic impact in tumorigenesis
• Role of antioxidant enzymes and factors in cancer
• Cytogenetic in-silico modeling in early cancer diagnosis
• Role of DNA repair mechanism in cancer prevention
• Role of non-coding RNAs in oxidative stress, DNA damage response, and cancer progression