Among several risk factors, diet, physical activity, and smoking have been recognized by WHO as explanatory factors of the 75% of cardiovascular disease incidence in developed countries. Furthermore, those lifestyle characteristics are considered as the most important ones, because they are modifiable. Several observational and clinical studies have already suggested that people with high intakes of fruits, vegetables, and olive oil experience lower risk of coronary heart disease events. Long-term adherence to a type of diet in this context, like the Mediterranean one, has been associated with a reduction in inflammation and coagulation markers levels, hypertension incidence, stabilization and reduction of body weight, and lipid levels management. Furthermore, physical active lifestyle has been related with lower cardiovascular outcomes in the field of primary and secondary prevention, while smoking and passive smoking have shown atherogenic effects in several clinical and population studies. Recently high rates of longevity and healthy aging that have been traced in some populations, irrespectively of their socio-economic status, have attracted the interest of scientific community. With the increasing rates of cardiovascular disease universally, understanding the mechanisms of lifestyle factors and gene-environmental interactions is of high importance for public health.

In this context, we invite authors to present original research, as well as review articles that will stimulate the continuing efforts in defining the role of lifestyle factors and gene interactions on cardiovascular longevity. We are particularly interested in manuscripts that report the clinical applications of lifestyle interventions on cardiovascular prevention and longevity, but reports on population studies are also welcomed. Reviews or meta-analyses that summarize the results of latest clinical trials and their implications on treatment practice in lifestyle modification are strongly recommended.

Potential topics include, but are not limited to:

• Diet on primary cardiovascular disease prevention
• Exercise on cardiovascular disease prevention
• Passive smoking and cardiovascular disease
• Psychosocial factors and primary prevention