Liver cirrhosis is a major cause of death worldwide. According to the most recent report of the global, regional, and national burden of liver cirrhosis by cause in 195 countries and territories 1990–2017, liver cirrhosis related deaths constitute 2.4% of total deaths globally in 2017 as compared to 1.9% in 1990; the number of liver cirrhosis related deaths globally is also increased from less than 899000 deaths in 1990 to more than 1.32 million deaths in 2017.

Lots of novel therapies for liver cirrhosis and its complications have been greatly evolved during the past decades. However, liver transplantation remains the sole curative treatment option. Given the dismal prognosis of liver cirrhosis, it is very important for clinicians and patients to understand the potential risk factors for early death and therapeutic algorithms.

The aim of this Special Issue is to collate original research articles and review articles that explore the prognostic assessment and management of liver cirrhosis. We are particularly interested in high-quality systematic reviews and meta-analyses in this field.

Potential topics include but are not limited to the following:

• Short- and long-term follow-up outcomes of liver cirrhosis
• Novel biomarkers or mathematical models for assessing the short- and long-term survival of liver cirrhosis
• Novel stages of liver cirrhosis
• Role of nutritional status, portal haemodynamic status, cardiac function, and renal function for the prognostic assessment of liver cirrhosis
• Impact of therapeutic options on the prognosis of liver cirrhosis, such as direct antiviral drugs, statins, anticoagulants, non-selective beta-blockers in ascites, early use of transjugular intrahepatic portosystemic shunt in high-risk variceal bleeding, endoscopic treatment of variceal bleeding, etc.
• Impact of portal vein thrombosis on the prognosis of liver cirrhosis
• Management of upper gastrointestinal bleeding, ascites, hepatic encephalopathy, hepatic hydrothorax, hypersplenism, hepatic myelopathy, and portal vein thrombosis in liver cirrhosis
• Early use of TIPS in severe complications of liver cirrhosis
• Subclassificaiton of acute kidney injury in liver cirrhosis
• Early identification and management of acute kidney injury in liver cirrhosis