Some of the most significant advances in medicine and biology in recent years have been made possible by new technology. Emerging biologicals and therapeutics could involve proteins, enzymes, nucleotides, and small molecules. Thousands of custom peptides, monoclonal antibodies, enzymes, and small molecules have been generated, clinically developed, and approved for a range of targets, including diseases, agricultural application, growth promotion, pharmaceutical preparations, and preventive or prophylactic tools. The emerging biologicals and the next generation therapeutics implemented various emerging technologies comprising molecular modeling, proteomics and metabolomics, next-generation sequencing, single-cell sequencing, and high-performance computing.

Because of its impact on public health, human and animal welfare, microbial infections have drawn the attention of scientists to discovering new agents. Despite a large number of antimicrobial development trials, no new antibacterial classes have been developed in the last few years. Drug resistance, microbial mutations, and the appearance of novel microbes all need the creation of new antimicrobials. The biggest challenge in developing new pharmaceuticals is the time it takes from development to approval. A greater number of authorized pharmaceuticals could be obtained if the drug discovery process is hastened using computational tools and experimental identification processes.

This Special Issue is a forum for discussing high-quality research in all fields related to emerging biologicals and next-generation therapeutics. This Special Issue comprises but is not limited to proteins, enzymes, nucleotides, and small molecules development and applications as therapeutic agents. Papers using computational tools to deliver scientific new data are also welcome. This Issue will give special attention to chemotherapeutics and biologicals against infectious diseases such as bacteria, fungi, viruses, insects, or helminths. We are also particularly interested in research that includes wide applications in medicine, pharmacy, veterinary, biology, chemistry and related disciplines. We welcome original research and review articles.

Potential topics include but are not limited to the following:

• Bioinformatics, synthesis, and characterization of new antimicrobial compounds
• High-throughput screening of lead antimicrobial compounds
• Molecular characterization of antimicrobial targets
• Molecular dynamics and mechanisms of drug-receptor interactions
• Proteomics and genomics and microbial targets
• Drug design and discovery of new antimicrobials
• Molecular/biochemical/cellular and experimental pharmacology of new antimicrobials
• Biopharmaceuticals development and optimization
• Chemistry and biology of proteins and enzymes of microbes
• Natural products evaluation and application in treating microbes