3D printing is a revolutionary technology that is developing rapidly and has a wide range of potential applications in orthopedics, bringing new hope in achieving precise and personalized treatment. Research on the application of 3D printing technology in orthopedics mainly focuses on the following aspects: fabricating personalized rehabilitation braces for orthopedic treatment; preparing 1:1 lesion models, which are convenient for designing surgical schemes, conducting preoperative surgical drills, and improving surgeon-patient communication; fabricating personalized surgical guides, saving operation time and reducing radiation caused by repeated intraoperative fluoroscopy; preparing personalized metal implants, bringing new solutions to the problem of bone defects; and fabricating new type of tissues and organs that can be compounded by cells and materials.

In this Special Issue, we invite investigators to contribute original research articles in the clinical application of 3D printing technology in orthopedics, its development in regenerative medicine, and to fully explore the potential of 3D printing technology in biomedicine. Review articles are also welcomed.

Potential topics include but are not limited to the following:

• Clinical application value of 3D printing technology in orthopedics
• Development prospects for 3D printing technology
• Problems in clinical applications of 3D printing technology and factors restricting its development
• Development prospects of 3D printing technology in regenerative medicine
• Application of 3D printing technology in tissue engineering