Reactive oxygen species (ROS) induce degradation of cellular macromolecules such as DNA, protein, and lipid and thus lead to cellular oxidative damage. Many drugs and xenobiotics contribute to the formation of free radicals in the body, inducing oxidative stress as a mechanism of toxicity. In the laboratory, many diseases (cancer, diabetes, atherosclerosis, hypertension, Alzheimer's, and Parkinsonism) and cellular senescence as well as many inflammatory conditions developed as models by certain chemical inducers with ROS generation as a mechanism.

Natural antioxidants have a wide range of biological activities and fewer side effects. Currently, a plethora of phytochemical antioxidants could be used in healthcare to maintain normal homeostasis and for prevention and treatment of many diseases and toxicities. Targeting of the molecular mechanisms of antioxidants remains the primary focus of many investigators for better understanding of their biological activities.

This special issue is dedicated to integrate the previous and the current therapeutic and protective use of antioxidants against drugs and xenobiotics toxicity. We cordially invite researchers to contribute their original articles and reviews in our special issue.

Potential topics include but are not limited to the following:

• Isolation, chemical characterization, and pharmacological evaluation antioxidants
• Identification of novel phenolics and polyphenolics as therapeutic agents
• Antioxidants against drugs and chemicals' toxicities
• Implication of antioxidants in disease prevention
• Prophylactic and therapeutic roles of antioxidants against different chemically induced disease models including cancer, diabetes, neurodegenerative, cardiovascular, metabolic abnormalities, and inflammatory conditions
• Novel phytochemical antioxidants and their mechanism of actions