The liver is an essential metabolic organ which governs body energy metabolism connected with adipose tissue and skeletal muscle among other tissues. There is a significant worldwide obesity epidemic that continues to grow every year caused by multiple factors, with diet and lifestyle being the most researched and therefore most important.

Among the several metabolic complications of obesity is the potential for the development of nonalcoholic fatty liver disease (NAFLD). The pathology of NAFLD is difficult to recognize or diagnose especially in early stages without a biopsy and therefore can remain undetected for significant time allowing the disease to progress. For NAFLD, it is crucial to achieve early detection to be able to start adequate treatment including changes in diet and lifestyle in the first stages of the disease when the pathology is reversible. The reversal is more challenging when the patient has developed nonalcoholic steatohepatitis (NASH) and the disease is irreversible in the cirrhosis stage.

When the liver becomes damaged, this can lead to some metabolic functions of the tissue to be altered and the patient can develop type 2 diabetes (T2D), visceral obesity, and cardiovascular disease related to elevated plasmatic cholesterol, triglycerides, transaminases, and others that indicate hepatic disorders and oxidative stress.

In this special issue, we welcome review and original manuscripts to assemble the latest progress to combat NAFLD, NASH, and cirrhosis mainly related to overweight and obesity which are increasingly prevalent in today's society.

Potential topics include but are not limited to the following:

• Diets and lifestyle studies associated with obesity and NALFD
• New diagnostic indicators and techniques for recognizing NAFLD
• Relationship between NAFLD and oxidative stress, ROS, etc.
• Overweight and obesity relation with diabetes
• Insulin resistance and NAFLD
• Inflammation in NAFLD