Safety and long-term outcomes of anatomic left hepatic trisectionectomy for intermediate and advanced hepatocellular carcinoma
Tao Zheng
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
These authors contributed equally to this work.Search for more papers by this authorFeng Xie
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
These authors contributed equally to this work.Search for more papers by this authorLi Geng
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
Search for more papers by this authorCheng-Jun Sui
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
Search for more papers by this authorDing-Hua Dai
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
Search for more papers by this authorRong-Xi Shen
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
Search for more papers by this authorLong Yan
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
Search for more papers by this authorCorresponding Author
Jia-Mei Yang
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
Correspondence
Prof Jia-Mei Yang, Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, 200438, China. Email: [email protected]
Search for more papers by this authorTao Zheng
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
These authors contributed equally to this work.Search for more papers by this authorFeng Xie
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
These authors contributed equally to this work.Search for more papers by this authorLi Geng
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
Search for more papers by this authorCheng-Jun Sui
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
Search for more papers by this authorDing-Hua Dai
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
Search for more papers by this authorRong-Xi Shen
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
Search for more papers by this authorLong Yan
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
Search for more papers by this authorCorresponding Author
Jia-Mei Yang
Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China
Correspondence
Prof Jia-Mei Yang, Department of Special Treatment and Liver Transplantation, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, 200438, China. Email: [email protected]
Search for more papers by this authorAbstract
Background and Aim
Anatomic left hepatic trisectionectomy (ALHT) is a complex hepatic resection, and its outcomes in hepatocellular carcinoma (HCC) still remain unclear. This paper focuses on the assessment of the safety and long-term effects of ALHT on intermediate and advanced HCC patients with tumors that occupy the left liver lobe.
Methods
This study performed a retrospective analysis of consecutive HCC patients who underwent ALHT in a single-center cohort between December 2004 and December 2011.
Results
ALHT was performed on 34 intermediate and advanced HCC patients (0.05%) of 17 064 HCC patients who had undergone hepatic resection. Among them, 12 (33.3%) developed postoperative complications. Based on the multivariate analysis, we found that a serum prealbumin level of 170 mg/L is associated with an increased risk of morbidity (P = 0.008). The one-year, two-year, three-year, and five-year overall survival rates were 61%, 27%, 11%, and 11%, respectively. The median overall survival was 13 months (range, 2–89 months). Based on the multivariate analysis, we also found that patients with an A/G ratio < 1.5 are more likely to have poor prognosis than those with an A/G ratio ≥ 1.5 (P = 0.014). Multiple tumors are associated with worse outcomes (P = 0.020).
Conclusions
ALHT is safe for intermediate and advanced HCC patients with tumors that occupy the left lobe and with preoperative Child–Pugh class A liver function. Low preoperative serum prealbumin level may increase the risk of postoperative complications. Although early intrahepatic recurrence rate is high, some patients, especially those with a single tumor and normal A/G ratio, exhibit long-term survival.
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