D. A. Restivo, Department of Neurology, “Nuovo Garibaldi” Hospital, Catania, via Palermo, 95100, Catania, Italy (tel.: +39 095-7598124; fax: +390957598105; e-mail: [email protected]; [email protected]).

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Abstract

Objective: To evaluate the efficacy of botulinum neurotoxin type A (BoNT/A) for severe oro-pharyngeal dysphagia associated with multiple sclerosis (MS).

Patients and methods: BoNT/A was injected percutaneously into the hyperactive cricopharyngeal muscle of 14 dysphagic MS patients under electromyographic control. Patients were evaluated by videofluoroscopic and electromyographic examinations and by the Penetration/Aspiration Scale (PAS), at week 1, 4, 12, 16, 18, and 24 after BoNT/A injection.

Results: All patients showed a significant improvement in all the swallowing outcome measures.

Conclusion: No specific treatment for oro-pharyngeal dysphagia related to MS has been described to date. Our preliminary findings suggest a potential benefit from BoNT/A treatment in MS patients with dysphagia associated with upper esophageal sphincter hyperactivity.

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Volume18, Issue3

March 2011

Pages 486-490

Botulinum toxin improves dysphagia associated with multiple sclerosis

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Botulinum toxin improves dysphagia associated with multiple sclerosis

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