NODULAR GASTRITIS WITH HELICOBACTER PYLORI INFECTION IS STRONGLY ASSOCIATED WITH DIFFUSE-TYPE GASTRIC CANCER IN YOUNG PATIENTS
Corresponding Author
Tomoari Kamada
Division of Gastroenterology, Department of Internal Medicine,
Tomoari Kamada, Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Matsushima 577, Kurashiki 701-0192, Japan. Email: [email protected]Search for more papers by this authorAki Tanaka
Division of Gastroenterology, Department of Internal Medicine,
Search for more papers by this authorYoshiyuki Yamanaka
Division of Gastroenterology, Department of Internal Medicine,
Search for more papers by this authorNoriaki Manabe
Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki,
Search for more papers by this authorHiroaki Kusunoki
Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki,
Search for more papers by this authorMasaki Miyamoto
Department of General Medicine, Hiroshima Prefectural Hospital, Departments of
Search for more papers by this authorJiro Hata
Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki,
Search for more papers by this authorKazuaki Chayama
Medicine and Molecular Science, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
Search for more papers by this authorKen Haruma
Division of Gastroenterology, Department of Internal Medicine,
Search for more papers by this authorCorresponding Author
Tomoari Kamada
Division of Gastroenterology, Department of Internal Medicine,
Tomoari Kamada, Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Matsushima 577, Kurashiki 701-0192, Japan. Email: [email protected]Search for more papers by this authorAki Tanaka
Division of Gastroenterology, Department of Internal Medicine,
Search for more papers by this authorYoshiyuki Yamanaka
Division of Gastroenterology, Department of Internal Medicine,
Search for more papers by this authorNoriaki Manabe
Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki,
Search for more papers by this authorHiroaki Kusunoki
Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki,
Search for more papers by this authorMasaki Miyamoto
Department of General Medicine, Hiroshima Prefectural Hospital, Departments of
Search for more papers by this authorJiro Hata
Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki,
Search for more papers by this authorKazuaki Chayama
Medicine and Molecular Science, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan
Search for more papers by this authorKen Haruma
Division of Gastroenterology, Department of Internal Medicine,
Search for more papers by this authorAbstract
Background: Nodular gastritis (NG), a particular type of gastritis, is now defined as antral nodularity. Recent studies have shown that NG is strongly associated with Helicobacter pylori infection, and we recently showed that it may be associated with diffuse-type gastric cancer of the corpus. We retrospectively investigated the relation between NG and gastric cancer in patients aged 29 years or less.
Patients and Methods: The study group comprised 150 patients (48 males, 102 females; mean age, 27.7 years) who were endoscopically diagnosed with NG and were less than 29 years of age; 3939 sex- and age-matched patients without NG who were H. pylori-positive served as the control group (1184 males, 2755 females; mean age, 27.5 years). We estimated the risk of gastric cancer development in patients with NG relative to that of patients without NG.
Results: The prevalence of gastric cancer was significantly higher in patients with NG than in the control patients (7/150; 4.7% vs 3/3939; 0.08%, P < 0.001). The odds ratio for the risk of gastric cancer in patients with NG was found to be 64.2 (95% confidence interval; 16.4–250.9). The seven cases of gastric cancer with NG showed the same characteristics: all were diagnosed histologically as the diffuse type and were located in the corpus with H. pylori infection.
Conclusion: NG with H. pylori infection is strongly associated with diffuse-type gastric cancer of the corpus in young patients.
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